Apolipoprotein E-related neurotoxicity as a therapeutic target for Alzheimer's disease (Q44591025)

4 December 2017

Apolipoprotein E-related neurotoxicity as a therapeutic target for Alzheimer's disease (English)

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4 December 2017

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4 December 2017

Marcos A Marques

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4 December 2017

1 January 2003

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Journal of Molecular Neuroscience

4 December 2017

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4 December 2017

20

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4 December 2017

327-337

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4 December 2017

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https://scigraph.springernature.com/pub.10.1385/jmn:20:3:327

4 December 2017

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cites work

Inhibition of apolipoprotein E degradation in a post-Golgi compartment by a cysteine protease inhibitor.

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12 December 2020

Apolipoprotein E: binding to soluble Alzheimer's beta-amyloid

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12 December 2020

Molecular determinants of the interaction between the C-terminal domain of Alzheimer's beta-amyloid peptide and apolipoprotein E alpha-helices

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12 December 2020

Binding of human apolipoprotein E to synthetic amyloid beta peptide: isoform-specific effects and implications for late-onset Alzheimer disease

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12 December 2020

Association of apolipoprotein epsilon 4 allele and neuropathologic findings in patients with dementia.

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12 December 2020

Apoprotein E-rich high density lipoproteins inhibit ovarian androgen synthesis

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12 December 2020

Apolipoprotein E is localized to the cytoplasm of human cortical neurons: a light and electron microscopic study

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12 December 2020

Expression of apolipoprotein E during nerve degeneration and regeneration

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12 December 2020

Apolipoprotein E: high-avidity binding to beta-amyloid and increased frequency of type 4 allele in late-onset familial Alzheimer disease

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12 December 2020

Apolipoprotein E activates Akt pathway in neuro-2a in an isoform-specific manner

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12 December 2020

Isoform-specific interactions of apolipoprotein E with microtubule-associated protein tau: implications for Alzheimer disease

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12 December 2020

Expression of human apolipoprotein E4 in neurons causes hyperphosphorylation of protein tau in the brains of transgenic mice

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12 December 2020

Oxidative insults are associated with apolipoprotein E genotype in Alzheimer's disease brain.

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12 December 2020

Remnant lipoprotein metabolism: key pathways involving cell-surface heparan sulfate proteoglycans and apolipoprotein E

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12 December 2020

Apolipoprotein E (ApoE), a novel heparin-binding protein inhibits the development of Kaposi's sarcoma-like lesions in BALB/c nu/nu mice

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12 December 2020

Purification of apolipoprotein E attenuates isoform-specific binding to beta-amyloid

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12 December 2020

Apolipoprotein E4 induces neuronal cell death under conditions of suppressed de novo cholesterol synthesis.

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12 December 2020

Is Alzheimer's disease an apolipoprotein E amyloidosis?

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12 December 2020

Stable expression and secretion of apolipoproteins E3 and E4 in mouse neuroblastoma cells produces differential effects on neurite outgrowth

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12 December 2020

Neuronal apoptosis by apolipoprotein E4 through low-density lipoprotein receptor-related protein and heterotrimeric GTPases.

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12 December 2020

Expression of apolipoprotein E by cultured vascular smooth muscle cells is controlled by growth state

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12 December 2020

Apolipoprotein E is present in hippocampal neurons without neurofibrillary tangles in Alzheimer's disease and in age-matched controls.

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12 December 2020

A "protease activation cascade" in the pathogenesis of Alzheimer's disease.

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12 December 2020

Behavioral phenotyping of GFAP-apoE3 and -apoE4 transgenic mice: apoE4 mice show profound working memory impairments in the absence of Alzheimer's-like neuropathology

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12 December 2020

Neurite degeneration elicited by apolipoprotein E peptides

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12 December 2020

Quantitation of apoE domains in Alzheimer disease brain suggests a role for apoE in Abeta aggregation

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12 December 2020

Differential effects of apolipoproteins E3 and E4 on neuronal growth in vitro

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12 December 2020

Expression of apolipoprotein E mRNA in rat microglia

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12 December 2020

Beta-VLDL protects against A beta(1-42) and apoE toxicity in human SH-SY5Y neuroblastoma cells

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12 December 2020

Apolipoprotein E allele-specific antioxidant activity and effects on cytotoxicity by oxidative insults and beta-amyloid peptides

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12 December 2020

Prominent axonopathy and disruption of axonal transport in transgenic mice expressing human apolipoprotein E4 in neurons of brain and spinal cord

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12 December 2020

ApoE immunoreactivity and microglial cells in Alzheimer's disease brain.

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12 December 2020

Apolipoprotein E: structure-function relationships

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12 December 2020

A thrombin cleavage fragment of apolipoprotein E exhibits isoform-specific neurotoxicity.

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12 December 2020

Endogenously expressed apolipoprotein E has different effects on cell lipid metabolism as compared to exogenous apolipoprotein E carried on triglyceride-rich particles

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12 December 2020

Apolipoprotein E is synthesized in the retina by Müller glial cells, secreted into the vitreous, and rapidly transported into the optic nerve by retinal ganglion cells.

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12 December 2020

The role of microglia in amyloid fibril formation.

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12 December 2020

Neuroimmune mechanisms in Alzheimer disease pathogenesis

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12 December 2020

Hypothesis: microtubule instability and paired helical filament formation in the Alzheimer disease brain are related to apolipoprotein E genotype

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12 December 2020

Conversion of brain apolipoprotein E to an insoluble form in a mouse model of Alzheimer disease.

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12 December 2020

Ameboid microglia as effectors of inflammation in the central nervous system.

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12 December 2020

Apolipoprotein E associated with astrocytic glia of the central nervous system and with nonmyelinating glia of the peripheral nervous system

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12 December 2020

Human apolipoprotein E isoform-specific differences in neuronal sprouting in organotypic hippocampal culture

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12 December 2020

Apolipoprotein E fragments present in Alzheimer's disease brains induce neurofibrillary tangle-like intracellular inclusions in neurons

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12 December 2020

Localization of a domain in apolipoprotein E with both cytostatic and cytotoxic activity

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12 December 2020

Synaptic loss is accompanied by an increase in synaptic area in the dentate gyrus of aged human apolipoprotein E4 transgenic mice

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12 December 2020

Alzheimer A beta neurotoxicity: promotion by antichymotrypsin, ApoE4; inhibition by A beta-related peptides

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12 December 2020

Apolipoprotein E isoform-dependent amyloid deposition and neuritic degeneration in a mouse model of Alzheimer's disease

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12 December 2020

Apolipoprotein E in animal models of CNS injury and in Alzheimer's disease

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12 December 2020

Cell-derived apolipoprotein E (ApoE) particles inhibit vascular cell adhesion molecule-1 (VCAM-1) expression in human endothelial cells

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12 December 2020

Microglial activation in Alzheimer disease: Association with APOE genotype.

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12 December 2020

Characterization of stable complexes involving apolipoprotein E and the amyloid beta peptide in Alzheimer's disease brain.

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12 December 2020

Apolipoprotein E in sporadic Alzheimer's disease: allelic variation and receptor interactions

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12 December 2020

ApoE genotypes in Australia: roles in early and late onset Alzheimer's disease and Down's syndrome.

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12 December 2020

Isolation and characterization of apolipoproteins from murine microglia. Identification of a low density lipoprotein-like apolipoprotein J-rich but E-poor spherical particle

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12 December 2020

Apolipoprotein E genotype in patients with alzheimer's disease: Implications for the risk of dementia among relatives

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12 December 2020

The endosomal trafficking of apolipoprotein E3 and E4 in cultured human brain neurons and astrocytes

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12 December 2020

Apolipoprotein E immunoreactivity in cerebral amyloid deposits and neurofibrillary tangles in Alzheimer's disease and kuru plaque amyloid in Creutzfeldt-Jakob disease.

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12 December 2020

A mechanism for the neuroprotective effect of apolipoprotein E: isoform-specific modification by the lipid peroxidation product 4-hydroxynonenal

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12 December 2020

Low density lipoprotein receptor-related protein mediates apolipoprotein E-dependent neurite outgrowth in a central nervous system-derived neuronal cell line

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12 December 2020

Attenuation of the neurotoxic effect of A beta amyloid peptide by apolipoprotein E.

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12 December 2020

Inhibition of apolipoprotein E-related neurotoxicity by glycosaminoglycans and their oligosaccharides

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12 December 2020

Human plasma lipoproteins regulate apolipoprotein E secretion from a post-Golgi compartment

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12 December 2020

Apolipoprotein E: a potent inhibitor of endothelial and tumor cell proliferation.

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12 December 2020

Apolipoprotein E: cholesterol transport protein with expanding role in cell biology

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12 December 2020

Peptide model of a highly conserved, N-terminal domain of apolipoprotein E is able to modulate lipoprotein binding to a member of the class A scavenger receptor family.

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12 December 2020

APOE and the regulation of microglial nitric oxide production: a link between genetic risk and oxidative stress

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12 December 2020

Evidence that the APOE locus influences rate of disease progression in late onset familial Alzheimer's Disease but is not causative

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12 December 2020

The presence of apoE4, not the absence of apoE3, contributes to AD pathology

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12 December 2020

Senile plaques stimulate microglia to release a neurotoxin found in Alzheimer brain.

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12 December 2020

A test of the cytosolic apolipoprotein E hypothesis fails to detect the escape of apolipoprotein E from the endocytic pathway into the cytosol and shows that direct expression of apolipoprotein E in the cytosol is cytotoxic.

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12 December 2020

Distinct apolipoprotein E isoform preference for inhibition of smooth muscle cell migration and proliferation

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12 December 2020

Neurotoxic effects of apolipoprotein E4 are mediated via dysregulation of calcium homeostasis

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12 December 2020

Apolipoprotein E epsilon4 associated with chronic traumatic brain injury in boxing.

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12 December 2020

Apolipoprotein E inhibits neointimal hyperplasia after arterial injury in mice

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12 December 2020

Active microglia, sick astroglia and Alzheimer type dementias

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12 December 2020

Beta-amyloid peptide interacts specifically with the carboxy-terminal domain of human apolipoprotein E: relevance to Alzheimer's disease.

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12 December 2020

Perlecan mediates the antiproliferative effect of apolipoprotein E on smooth muscle cells. An underlying mechanism for the modulation of smooth muscle cell growth?

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12 December 2020

Gene dose of apolipoprotein E type 4 allele and the risk of Alzheimer's disease in late onset families

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12 December 2020

Apolipoprotein E in the genetics and epidemiology of Alzheimer's disease.

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12 December 2020

Inflammatory glia mediate delayed neuronal damage after ischemia in the central nervous system

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12 December 2020

Apolipoprotein E binds to and potentiates the biological activity of ciliary neurotrophic factor

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12 December 2020

The inhibitory effect of apolipoprotein E4 on neurite outgrowth is associated with microtubule depolymerization

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12 December 2020

Apolipoprotein E and Alzheimer's disease: the protective effects of ApoE2 and E3.

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12 December 2020

Amino-terminus truncated apolipoprotein E is the major species in amyloid deposits in Alzheimer's disease-affected brains: a possible role for apolipoprotein E in Alzheimer's disease.

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12 December 2020

Neurotoxicity of the 22 kDa thrombin-cleavage fragment of apolipoprotein E and related synthetic peptides is receptor-mediated

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12 December 2020

Lysosomal degradation and sorting of apolipoprotein E in macrophages.

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12 December 2020

Expression of human apolipoprotein E reduces amyloid-beta deposition in a mouse model of Alzheimer's disease

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12 December 2020

Truncated apolipoprotein E (ApoE) causes increased intracellular calcium and may mediate ApoE neurotoxicity.

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12 December 2020

Genetic dissection of Alzheimer disease, a heterogeneous disorder

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12 December 2020

Dominant negative effects of apolipoprotein E4 revealed in transgenic models of neurodegenerative disease

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12 December 2020

Secretases as targets for the treatment of Alzheimer's disease

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12 December 2020

Human apolipoprotein E3 in aqueous solution. I. Evidence for two structural domains

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12 December 2020

Senile plaques in temporal lobe epilepsy.

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12 December 2020

Identifiers

DOI

10.1385/JMN:20:3:327

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PubMed ID

14501016

Dimensions Publication ID

4 December 2017

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PubMed ID

14501016