Syndecan 3 intramembrane proteolysis is presenilin/gamma-secretase-dependent and modulates cytosolic signaling (Q44592816)

4 December 2017

Syndecan 3 intramembrane proteolysis is presenilin/gamma-secretase-dependent and modulates cytosolic signaling (English)

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4 December 2017

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5

Bart De Strooper

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4 December 2017

Joachim G Schulz

1

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4 December 2017

Wim Annaert

2

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4 December 2017

Joël Vandekerckhove

3

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4 December 2017

Pascale Zimmermann

4

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4 December 2017

Guido David

6

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4 December 2017

language of work or name

English

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publication date

22 September 2003

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Journal of Biological Chemistry

4 December 2017

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4 December 2017

278

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4 December 2017

48651-48657

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4 December 2017

49

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Functions of cell surface heparan sulfate proteoglycans

4 December 2017

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https://api.crossref.org/works/10.1074%2FJBC.M308424200

Functional binding of secreted molecules to heparan sulfate proteoglycans in Drosophila

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M308424200

Regulation of cytoskeletal organization by syndecan transmembrane proteoglycans

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M308424200

PKCgamma regulates syndecan-2 inside-out signaling during xenopus left-right development.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M308424200

EphB/syndecan-2 signaling in dendritic spine morphogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M308424200

Fibroblast growth factor-specific modulation of cellular response by syndecan-4

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M308424200

Cortactin-Src kinase signaling pathway is involved in N-syndecan-dependent neurite outgrowth

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M308424200

Shedding of syndecan-1 and -4 ectodomains is regulated by multiple signaling pathways and mediated by a TIMP-3-sensitive metalloproteinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M308424200

Pervanadate activation of intracellular kinases leads to tyrosine phosphorylation and shedding of syndecan-1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M308424200

Regulated shedding of syndecan-1 and -4 ectodomains by thrombin and growth factor receptor activation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M308424200

Regulated intramembrane proteolysis: a control mechanism conserved from bacteria to humans

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M308424200

Deficiency of presenilin-1 inhibits the normal cleavage of amyloid precursor protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M308424200

A presenilin-1-dependent gamma-secretase-like protease mediates release of Notch intracellular domain

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M308424200

Presenilin-dependent gamma-secretase-like intramembrane cleavage of ErbB4.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M308424200

gamma -Secretase cleavage and nuclear localization of ErbB-4 receptor tyrosine kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M308424200

The Notch ligands, Delta1 and Jagged2, are substrates for presenilin-dependent "gamma-secretase" cleavage

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M308424200

Nectin-1alpha, an immunoglobulin-like receptor involved in the formation of synapses, is a substrate for presenilin/gamma-secretase-like cleavage

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M308424200

Presenilin-dependent intramembrane proteolysis of CD44 leads to the liberation of its intracellular domain and the secretion of an Abeta-like peptide

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M308424200

Assembly of the gamma-secretase complex involves early formation of an intermediate subcomplex of Aph-1 and nicastrin

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M308424200

A presenilin-1/gamma-secretase cleavage releases the E-cadherin intracellular domain and regulates disassembly of adherens junctions

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M308424200

Proteolytic processing of low density lipoprotein receptor-related protein mediates regulated release of its intracellular domain

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M308424200

A cell biological perspective on Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M308424200

Photoactivated gamma-secretase inhibitors directed to the active site covalently label presenilin 1

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M308424200

Presenilin 2 deficiency causes a mild pulmonary phenotype and no changes in amyloid precursor protein processing but enhances the embryonic lethal phenotype of presenilin 1 deficiency

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M308424200

Presenilin 1 controls gamma-secretase processing of amyloid precursor protein in pre-golgi compartments of hippocampal neurons

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M308424200

Presenilin-dependent gamma-secretase processing of beta-amyloid precursor protein at a site corresponding to the S3 cleavage of Notch

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M308424200

Ectodermal syndecan-2 mediates left-right axis formation in migrating mesoderm as a cell-nonautonomous Vg1 cofactor

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M308424200

A loss of function mutation of presenilin-2 interferes with amyloid beta-peptide production and notch signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M308424200

The amyloid precursor protein (APP)-cytoplasmic fragment generated by gamma-secretase is rapidly degraded but distributes partially in a nuclear fraction of neurones in culture

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M308424200

A transcriptionally [correction of transcriptively] active complex of APP with Fe65 and histone acetyltransferase Tip60

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M308424200

Characterization of a presenilin-mediated amyloid precursor protein carboxyl-terminal fragment gamma. Evidence for distinct mechanisms involved in gamma -secretase processing of the APP and Notch1 transmembrane domains

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M308424200

Embryonic lethality in mice homozygous for a processing-deficient allele of Notch1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M308424200

The GxxxG motif: a framework for transmembrane helix-helix association

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M308424200

Self-association of N-syndecan (syndecan-3) core protein is mediated by a novel structural motif in the transmembrane domain and ectodomain flanking region

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M308424200

Requirements for presenilin-dependent cleavage of notch and other transmembrane proteins.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M308424200

Nuclear translocation and transcription regulation by the membrane-associated guanylate kinase CASK/LIN-2

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M308424200

Human CASK/LIN-2 binds syndecan-2 and protein 4.1 and localizes to the basolateral membrane of epithelial cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M308424200

Interaction with telencephalin and the amyloid precursor protein predicts a ring structure for presenilins

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M308424200

Mechanism of the cleavage specificity of Alzheimer's disease gamma-secretase identified by phenylalanine-scanning mutagenesis of the transmembrane domain of the amyloid precursor protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M308424200

Beta-amyloid precursor protein. Location of transmembrane domain and specificity of gamma-secretase cleavage

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M308424200

Presenilin-1 deficiency leads to loss of Cajal-Retzius neurons and cortical dysplasia similar to human type 2 lissencephaly

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M308424200

Tbr1 regulates differentiation of the preplate and layer 6.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M308424200

Mice lacking both presenilin genes exhibit early embryonic patterning defects

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M308424200

Changes in cerebral cortex size are governed by fibroblast growth factor during embryogenesis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M308424200

A Novel γ-Secretase Assay Based on Detection of the Putative C-terminal Fragment-γ of Amyloid β Protein Precursor

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M308424200

Reeling CASK into the nucleus

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M308424200

21 January 2018

Identifiers

DOI

10.1074/JBC.M308424200

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4 December 2017

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