RhoA binds to the amino terminus of MEKK1 and regulates its kinase activity (Q44634028)

4 December 2017

RhoA binds to the amino terminus of MEKK1 and regulates its kinase activity (English)

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4 December 2017

4

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4 December 2017

Ewen D Gallagher

1

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4 December 2017

Stephen Gutowski

series ordinal

2

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4 December 2017

Paul C Sternweis

series ordinal

3

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4 December 2017

language of work or name

English

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publication date

27 October 2003

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Journal of Biological Chemistry

4 December 2017

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4 December 2017

279

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4 December 2017

3

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4 December 2017

1872-1877

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JNK or IKK, AP-1 or NF-kappaB, which are the targets for MEK kinase 1 action?

4 December 2017

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M309525200

Mitogen-activated protein (MAP) kinase pathways: regulation and physiological functions

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M309525200

Identification of a dual specificity kinase that activates the Jun kinases and p38-Mpk2

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M309525200

MEKK1 phosphorylates MEK1 and MEK2 but does not cause activation of mitogen-activated protein kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M309525200

Activation of the IkappaB alpha kinase complex by MEKK1, a kinase of the JNK pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M309525200

HTLV-I Tax protein binds to MEKK1 to stimulate IkappaB kinase activity and NF-kappaB activation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M309525200

Role of MEKK1 in cell survival and activation of JNK and ERK pathways defined by targeted gene disruption

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M309525200

MEK kinase 1 is critically required for c-Jun N-terminal kinase activation by proinflammatory stimuli and growth factor-induced cell migration.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M309525200

A divergence in the MAP kinase regulatory network defined by MEK kinase and Raf

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M309525200

Cloning of rat MEK kinase 1 cDNA reveals an endogenous membrane-associated 195-kDa protein with a large regulatory domain

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M309525200

Molecular cloning of mitogen-activated protein/ERK kinase kinases (MEKK) 2 and 3. Regulation of sequential phosphorylation pathways involving mitogen-activated protein kinase and c-Jun kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M309525200

Cloning of a novel mitogen-activated protein kinase kinase kinase, MEKK4, that selectively regulates the c-Jun amino terminal kinase pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M309525200

Role of the amino-terminal domains of MEKKs in the activation of NF kappa B and MAPK pathways and in the regulation of cell proliferation and apoptosis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M309525200

MEKK1 binds directly to the c-Jun N-terminal kinases/stress-activated protein kinases

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M309525200

JNKK1 organizes a MAP kinase module through specific and sequential interactions with upstream and downstream components mediated by its amino-terminal extension

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M309525200

MEKK1 binds raf-1 and the ERK2 cascade components

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M309525200

NIK is a new Ste20-related kinase that binds NCK and MEKK1 and activates the SAPK/JNK cascade via a conserved regulatory domain

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M309525200

Direct activation of mitogen-activated protein kinase kinase kinase MEKK1 by the Ste20p homologue GCK and the adapter protein TRAF2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M309525200

Ste5 tethers multiple protein kinases in the MAP kinase cascade required for mating in S. cerevisiae

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M309525200

Complexes between STE5 and components of the pheromone-responsive mitogen-activated protein kinase module

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M309525200

The PHD domain of MEKK1 acts as an E3 ubiquitin ligase and mediates ubiquitination and degradation of ERK1/2

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M309525200

14-3-3 proteins interact with specific MEK kinases

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M309525200

Direct interaction between Ras and the kinase domain of mitogen-activated protein kinase kinase kinase (MEKK1).

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M309525200

MEK kinases are regulated by EGF and selectively interact with Rac/Cdc42

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M309525200

Ras and Rho GTPases: a family reunion

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M309525200

The small GTP-binding protein rac regulates growth factor-induced membrane ruffling

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M309525200

MEK kinase 1 gene disruption alters cell migration and c-Jun NH2-terminal kinase regulation but does not cause a measurable defect in NF-kappa B activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M309525200

MEK kinase 1 (MEKK1) transduces c-Jun NH2-terminal kinase activation in response to changes in the microtubule cytoskeleton.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M309525200

p115 Rho GTPase activating protein interacts with MEKK1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M309525200

Binding of JNK/SAPK to MEKK1 is regulated by phosphorylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M309525200

p115 RhoGEF, a GTPase activating protein for Galpha12 and Galpha13

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M309525200

Activation of the IkappaB kinase complex by TRAF6 requires a dimeric ubiquitin-conjugating enzyme complex and a unique polyubiquitin chain

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M309525200

WNK1, a novel mammalian serine/threonine protein kinase lacking the catalytic lysine in subdomain II

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M309525200

A conserved binding motif defines numerous candidate target proteins for both Cdc42 and Rac GTPases

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M309525200

Identification of the Rho-binding domain of p160ROCK, a Rho-associated coiled-coil containing protein kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M309525200

Rhotekin, a new putative target for Rho bearing homology to a serine/threonine kinase, PKN, and rhophilin in the rho-binding domain

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M309525200

The PRK2 kinase is a potential effector target of both Rho and Rac GTPases and regulates actin cytoskeletal organization

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M309525200

Complexes of Ras.GTP with Raf-1 and mitogen-activated protein kinase kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M309525200

Mammalian Ras interacts directly with the serine/threonine kinase Raf

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M309525200

A brain serine/threonine protein kinase activated by Cdc42 and Rac1

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M309525200

Signal-regulated activation of serum response factor is mediated by changes in actin dynamics

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M309525200

21 January 2018

Identifiers

DOI

10.1074/JBC.M309525200

1 reference

4 December 2017

1 reference