Orphan nuclear receptors, PXR and LXR: new ligands and therapeutic potential (Q44783820)

6 December 2017

title

Orphan nuclear receptors, PXR and LXR: new ligands and therapeutic potential (English)

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6 December 2017

Haibiao Gong

1

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6 December 2017

Wen Xie

series ordinal

2

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6 December 2017

language of work or name

English

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publication date

1 February 2004

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Expert Opinion on Therapeutic Targets

6 December 2017

published in

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6 December 2017

volume

8

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6 December 2017

issue

1

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6 December 2017

page(s)

49-54

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The RXR heterodimers and orphan receptors

6 December 2017

cites work

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https://api.crossref.org/works/10.1517%2F14728222.8.1.49

An orphan nuclear receptor activated by pregnanes defines a novel steroid signaling pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.8.1.49

The human orphan nuclear receptor PXR is activated by compounds that regulate CYP3A4 gene expression and cause drug interactions

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.8.1.49

Identification of a human nuclear receptor defines a new signaling pathway for CYP3A induction

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.8.1.49

SXR, a novel steroid and xenobiotic-sensing nuclear receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.8.1.49

Orphan nuclear receptors: the exotics of xenobiotics.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.8.1.49

The nuclear pregnane X receptor: a key regulator of xenobiotic metabolism

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.8.1.49

The pregnane X receptor: a promiscuous xenobiotic receptor that has diverged during evolution

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.8.1.49

Orphan nuclear receptors constitutive androstane receptor and pregnane X receptor share xenobiotic and steroid ligands

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.8.1.49

The nuclear receptor PXR is a lithocholic acid sensor that protects against liver toxicity

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.8.1.49

An essential role for nuclear receptors SXR/PXR in detoxification of cholestatic bile acids.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.8.1.49

Identification of an endogenous ligand that activates pregnane X receptor-mediated sterol clearance

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.8.1.49

Identification of bile acid precursors as endogenous ligands for the nuclear xenobiotic pregnane X receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.8.1.49

Peptide mimetic HIV protease inhibitors are ligands for the orphan receptor SXR.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.8.1.49

Humanized xenobiotic response in mice expressing nuclear receptor SXR.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.8.1.49

The human nuclear xenobiotic receptor PXR: structural determinants of directed promiscuity

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.8.1.49

The orphan nuclear receptor SXR coordinately regulates drug metabolism and efflux

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.8.1.49

Pruritus and cholestasis: therapeutic options

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.8.1.49

Markedly reduced bile acid synthesis but maintained levels of cholesterol and vitamin D metabolites in mice with disrupted sterol 27-hydroxylase gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.8.1.49

Vitamin K2 regulation of bone homeostasis is mediated by the steroid and xenobiotic receptor SXR.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.8.1.49

LXR, a nuclear receptor that defines a distinct retinoid response pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.8.1.49

Autoregulation of the human liver X receptor alpha promoter

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.8.1.49

Synthetic LXR ligand inhibits the development of atherosclerosis in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.8.1.49

Cholesterol and bile acid metabolism are impaired in mice lacking the nuclear oxysterol receptor LXR alpha

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.8.1.49

Reciprocal regulation of inflammation and lipid metabolism by liver X receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.8.1.49

Role of LXRs in control of lipogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.8.1.49

The LXR ligand T0901317 induces severe lipogenesis in the db/db diabetic mouse

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.8.1.49

Structural requirements of ligands for the oxysterol liver X receptors LXRalpha and LXRbeta

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.8.1.49

A potent synthetic LXR agonist is more effective than cholesterol loading at inducing ABCA1 mRNA and stimulating cholesterol efflux

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.8.1.49

Induction of intestinal ATP-binding cassette transporters by a phytosterol-derived liver X receptor agonist

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.8.1.49

A natural product ligand of the oxysterol receptor, liver X receptor.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.8.1.49

The three-dimensional structure of the liver X receptor beta reveals a flexible ligand-binding pocket that can accommodate fundamentally different ligands

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.8.1.49

Polyunsaturated fatty acids suppress sterol regulatory element-binding protein 1c promoter activity by inhibition of liver X receptor (LXR) binding to LXR response elements

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.8.1.49

Auto-oxidized cholesterol sulfates are antagonistic ligands of liver X receptors: implications for the development and treatment of atherosclerosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.8.1.49

The orphan nuclear receptor LXRalpha is positively and negatively regulated by distinct products of mevalonate metabolism

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.8.1.49

Regulation of cholesterol homeostasis and lipid metabolism in skeletal muscle by liver X receptors.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.8.1.49

21 January 2018

Identifiers

DOI

10.1517/14728222.8.1.49

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6 December 2017

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