Transcriptomics of wild-type mice and mice lacking ADAMTS-5 activity identifies genes involved in osteoarthritis initiation and cartilage destruction. (Q44813895)

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scientific article published in June 2013

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English	Transcriptomics of wild-type mice and mice lacking ADAMTS-5 activity identifies genes involved in osteoarthritis initiation and cartilage destruction.	scientific article published in June 2013

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24 February 2020

Transcriptomics of wild-type mice and mice lacking ADAMTS-5 activity identifies genes involved in osteoarthritis initiation and cartilage destruction (English)

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24 February 2020

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transcriptomics

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John F. Bateman

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Christopher B Little

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Lynn Rowley

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24 February 2020

Daniele Belluoccio

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Ben Chan

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Katrina Bell

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1 June 2013

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24 February 2020

Arthritis and Rheumatism

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1547-1560

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24 February 2020

ADAMTS5 is the major aggrecanase in mouse cartilage in vivo and in vitro

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https://api.crossref.org/works/10.1002%2FART.37900

21 January 2018

Deletion of active ADAMTS5 prevents cartilage degradation in a murine model of osteoarthritis

1 reference

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Analysis of meniscal degeneration and meniscal gene expression

1 reference

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Genome-wide expression profiling reveals new candidate genes associated with osteoarthritis.

1 reference

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Identification of differentially expressed genes in trabecular bone from the iliac crest of osteoarthritic patients

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Zonal gene expression of chondrocytes in osteoarthritic cartilage

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Gene expression profile of the bone microenvironment in human fragility fracture bone

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Differential transcriptome analysis of intraarticular lesional vs intact cartilage reveals new candidate genes in osteoarthritis pathophysiology

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Differential expression of GADD45beta in normal and osteoarthritic cartilage: potential role in homeostasis of articular chondrocytes.

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Microarray gene expression profiling of osteoarthritic bone suggests altered bone remodelling, WNT and transforming growth factor-beta/bone morphogenic protein signalling

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Large-scale gene expression profiles, differentially represented in osteoarthritic synovium of the knee joint using cDNA microarray technology.

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Analysis of early changes in the articular cartilage transcriptisome in the rat meniscal tear model of osteoarthritis: pathway comparisons with the rat anterior cruciate transection model and with human osteoarthritic cartilage

1 reference

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21 January 2018

Microarray analysis reveals age-related differences in gene expression during the development of osteoarthritis in mice

1 reference

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21 January 2018

Joint immobilization prevents murine osteoarthritis and reveals the highly mechanosensitive nature of protease expression in vivo.

1 reference

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Blocking aggrecanase cleavage in the aggrecan interglobular domain abrogates cartilage erosion and promotes cartilage repair

1 reference

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21 January 2018

Cartilage intermediate layer protein 2 (CILP-2) is expressed in articular and meniscal cartilage and down-regulated in experimental osteoarthritis.

1 reference

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21 January 2018

Linear models and empirical bayes methods for assessing differential expression in microarray experiments

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Accurate normalization of real-time quantitative RT-PCR data by geometric averaging of multiple internal control genes

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The Degradome database: mammalian proteases and diseases of proteolysis

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Proteases involved in cartilage matrix degradation in osteoarthritis.

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21 January 2018

Autophagy is a protective mechanism in normal cartilage, and its aging-related loss is linked with cell death and osteoarthritis

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Injurious mechanical compression of bovine articular cartilage induces chondrocyte apoptosis

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21 January 2018

Physiology and pathophysiology of nitrosative and oxidative stress in osteoarthritic joint destruction

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21 January 2018

Enhanced apoptotic and reduced protective response in chondrocytes following endoplasmic reticulum stress in osteoarthritic cartilage.

1 reference

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Chondrogenesis, chondrocyte differentiation, and articular cartilage metabolism in health and osteoarthritis

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21 January 2018

Matrix metalloproteinase 13-deficient mice are resistant to osteoarthritic cartilage erosion but not chondrocyte hypertrophy or osteophyte development.

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21 January 2018

The orphan G-protein coupled receptor RDC1: evidence for a role in chondrocyte hypertrophy and articular cartilage matrix turnover

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21 January 2018

Wnt-beta-catenin signaling in the pathogenesis of osteoarthritis

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21 January 2018

Genome-wide association scan identifies a prostaglandin-endoperoxide synthase 2 variant involved in risk of knee osteoarthritis

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21 January 2018

Angiogenesis-associated crosstalk between collagens, CXC chemokines, and thrombospondin domain-containing proteins

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Global comparative transcriptome analysis of cartilage formation in vivo

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The role of α-dystrobrevin in striated muscle

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Cytokine receptor-like factor 1 is highly expressed in damaged human knee osteoarthritic cartilage and involved in osteoarthritis downstream of TGF-beta.

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Genome-wide and species-wide dissection of the genetics of arthritis severity in heterogeneous stock mice

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Genome-wide analyses of gene expression during mouse endochondral ossification

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Investigation of arthritic joint destruction by a novel fibroblast-based model

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C-type natriuretic peptide regulates cellular condensation and glycosaminoglycan synthesis during chondrogenesis.

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21 January 2018

Degradome expression profiling in human articular cartilage

1 reference

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21 January 2018

Cleavage of type II collagen by cathepsin K in human osteoarthritic cartilage

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Regulation and physiological roles of the calpain system in muscular disorders

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Calpain is involved in C-terminal truncation of human aggrecan

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Effects of Wnt3A and mechanical load on cartilage chondrocyte homeostasis

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Proteomic analysis of articular cartilage shows increased type II collagen synthesis in osteoarthritis and expression of inhibin betaA (activin A), a regulatory molecule for chondrocytes

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Activin A suppresses interleukin-1-induced matrix metalloproteinase 3 secretion in human chondrosarcoma cells

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Time-series transcriptional profiling yields new perspectives on susceptibility to murine osteoarthritis

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10.1002/ART.37900

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24 February 2020

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