p35/cyclin-dependent kinase 5 phosphorylation of ras guanine nucleotide releasing factor 2 (RasGRF2) mediates Rac-dependent Extracellular Signal-regulated kinase 1/2 activity, altering RasGRF2 and microtubule-associated protein 1b distribution in ne (Q44885123)

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English	p35/cyclin-dependent kinase 5 phosphorylation of ras guanine nucleotide releasing factor 2 (RasGRF2) mediates Rac-dependent Extracellular Signal-regulated kinase 1/2 activity, altering RasGRF2 and microtubule-associated protein 1b distribution in ne	scientific article

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PubMed publication ID

7 December 2017

p35/cyclin-dependent kinase 5 phosphorylation of ras guanine nucleotide releasing factor 2 (RasGRF2) mediates Rac-dependent Extracellular Signal-regulated kinase 1/2 activity, altering RasGRF2 and microtubule-associated protein 1b distribution in neurons (English)

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12 May 2020

phosphorylation

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J. Silvio Gutkind

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12 May 2020

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Sashi Kesavapany

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12 May 2020

Niranjana Amin

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12 May 2020

Ya-Li Zheng

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12 May 2020

Ruchika Nijhara

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12 May 2020

Howard Jaffe

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12 May 2020

Ram Sihag

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Satoru Takahashi

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12 May 2020

Ashok Kulkarni

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12 May 2020

Philip Grant

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Harish C Pant

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publication date

1 May 2004

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7 December 2017

Journal of Neuroscience

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12 May 2020

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12 May 2020

4421-4431

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12 May 2020

Migration defects of cdk5(-/-) neurons in the developing cerebellum is cell autonomous

1 reference

https://pubmed.ncbi.nlm.nih.gov/15128856

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cyclin dependent kinase-5 (CDK-5) phosphorylates neurofilament heavy (NF-H) chain to generate epitopes for antibodies that label neurofilament accumulations in amyotrophic lateral sclerosis (ALS) and is present in affected motor neurones in ALS

1 reference

https://pubmed.ncbi.nlm.nih.gov/15128856

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Conversion of p35 to p25 deregulates Cdk5 activity and promotes neurodegeneration

1 reference

https://pubmed.ncbi.nlm.nih.gov/15128856

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Phosphorylation of DARPP-32 by Cdk5 modulates dopamine signalling in neurons

1 reference

https://pubmed.ncbi.nlm.nih.gov/15128856

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Induction of rac-guanine nucleotide exchange activity of Ras-GRF1/CDC25(Mm) following phosphorylation by the nonreceptor tyrosine kinase Src.

1 reference

https://pubmed.ncbi.nlm.nih.gov/15128856

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Regulation of N-cadherin-mediated adhesion by the p35-Cdk5 kinase

1 reference

https://pubmed.ncbi.nlm.nih.gov/15128856

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cdk5/p25(nck5a) interaction with synaptic proteins in bovine brain

1 reference

https://pubmed.ncbi.nlm.nih.gov/15128856

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Neurotoxicity induces cleavage of p35 to p25 by calpain

1 reference

https://pubmed.ncbi.nlm.nih.gov/15128856

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Stimulation of Ras guanine nucleotide exchange activity of Ras-GRF1/CDC25(Mm) upon tyrosine phosphorylation by the Cdc42-regulated kinase ACK1

1 reference

https://pubmed.ncbi.nlm.nih.gov/15128856

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identification of a common protein association region in the neuronal Cdk5 activator

1 reference

https://pubmed.ncbi.nlm.nih.gov/15128856

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Synaptic localization of p39, a neuronal activator of cdk5

1 reference

https://pubmed.ncbi.nlm.nih.gov/15128856

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Neuronal cyclin-dependent kinase 5 activity is critical for survival.

1 reference

https://pubmed.ncbi.nlm.nih.gov/15128856

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

p35/cdk5 binds and phosphorylates beta-catenin and regulates beta-catenin/presenilin-1 interaction

1 reference

https://pubmed.ncbi.nlm.nih.gov/15128856

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Ras binding triggers ubiquitination of the Ras exchange factor Ras-GRF2.

1 reference

https://pubmed.ncbi.nlm.nih.gov/15128856

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Phosphorylation of Pak1 by the p35/Cdk5 kinase affects neuronal morphology

1 reference

https://pubmed.ncbi.nlm.nih.gov/15128856

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Phosphorylation of MEK1 by cdk5/p35 down-regulates the mitogen-activated protein kinase pathway

1 reference

https://pubmed.ncbi.nlm.nih.gov/15128856

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Neocortical cell migration: GABAergic neurons and cells in layers I and VI move in a cyclin-dependent kinase 5-independent manner.

1 reference

https://pubmed.ncbi.nlm.nih.gov/15128856

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cyclin-dependent kinase 5 (cdk5) activation requires interaction with three domains of p35.

1 reference

https://pubmed.ncbi.nlm.nih.gov/15128856

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cyclin-dependent kinase 5 prevents neuronal apoptosis by negative regulation of c-Jun N-terminal kinase 3.

1 reference

https://pubmed.ncbi.nlm.nih.gov/15128856

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Integration of calcium and Ras signalling.

1 reference

https://pubmed.ncbi.nlm.nih.gov/15128856

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cyclin-dependent kinase-5/p35 phosphorylates Presenilin 1 to regulate carboxy-terminal fragment stability.

1 reference

https://pubmed.ncbi.nlm.nih.gov/15128856

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

p35/Cdk5 pathway mediates soluble amyloid-beta peptide-induced tau phosphorylation in vitro

1 reference

https://pubmed.ncbi.nlm.nih.gov/15128856

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Truncation of CDK5 activator p35 induces intensive phosphorylation of Ser202/Thr205 of human tau.

1 reference

https://pubmed.ncbi.nlm.nih.gov/15128856

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

AbetaPP induces cdk5-dependent tau hyperphosphorylation in transgenic mice Tg2576.

1 reference

https://pubmed.ncbi.nlm.nih.gov/15128856

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Tau phosphorylation by cyclin-dependent kinase 5/p39 during brain development reduces its affinity for microtubules.

1 reference

https://pubmed.ncbi.nlm.nih.gov/15128856

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Phosphorylation of the Ras-GRF1 exchange factor at Ser916/898 reveals activation of Ras signaling in the cerebral cortex

1 reference

https://pubmed.ncbi.nlm.nih.gov/15128856

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Neuronal cdc2-like kinase: a cdc2-related protein kinase with predominantly neuronal expression

1 reference

https://pubmed.ncbi.nlm.nih.gov/15128856

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cyclin-dependent kinase-5 is involved in neuregulin-dependent activation of phosphatidylinositol 3-kinase and Akt activity mediating neuronal survival.

1 reference

https://pubmed.ncbi.nlm.nih.gov/15128856

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identification of a novel, membrane-associated neuronal kinase, cyclin-dependent kinase 5/p35-regulated kinase

1 reference

https://pubmed.ncbi.nlm.nih.gov/15128856

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Molecular cloning of cDNAs encoding a guanine-nucleotide-releasing factor for Ras p21

1 reference

https://pubmed.ncbi.nlm.nih.gov/15128856

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Tau domains, phosphorylation, and interactions with microtubules.

1 reference

https://pubmed.ncbi.nlm.nih.gov/15128856

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Calcium activation of Ras mediated by neuronal exchange factor Ras-GRF.

1 reference

https://pubmed.ncbi.nlm.nih.gov/15128856

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Neuronal cyclin-dependent kinase-5 phosphorylation sites in neurofilament protein (NF-H) are dephosphorylated by protein phosphatase 2A

1 reference

https://pubmed.ncbi.nlm.nih.gov/15128856

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

p35 is a neural-specific regulatory subunit of cyclin-dependent kinase 5

1 reference

https://pubmed.ncbi.nlm.nih.gov/15128856

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Activity and expression pattern of cyclin-dependent kinase 5 in the embryonic mouse nervous system.

1 reference

https://pubmed.ncbi.nlm.nih.gov/15128856

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Site-specific phosphorylation of synapsin I by mitogen-activated protein kinase and Cdk5 and its effects on physiological functions.

1 reference

https://pubmed.ncbi.nlm.nih.gov/15128856

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The N-terminal pleckstrin, coiled-coil, and IQ domains of the exchange factor Ras-GRF act cooperatively to facilitate activation by calcium

1 reference

https://pubmed.ncbi.nlm.nih.gov/15128856

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The cdk5/p35 kinase is essential for neurite outgrowth during neuronal differentiation

1 reference

https://pubmed.ncbi.nlm.nih.gov/15128856

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Targeted disruption of the cyclin-dependent kinase 5 gene results in abnormal corticogenesis, neuronal pathology and perinatal death

1 reference

https://pubmed.ncbi.nlm.nih.gov/15128856

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cellular phosphorylation of neurofilament heavy-chain by cyclin-dependent kinase-5 masks the epitope for monoclonal antibody N52.

1 reference

https://pubmed.ncbi.nlm.nih.gov/15128856

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cell cycle: reaching for a role for the Cks proteins

1 reference

https://pubmed.ncbi.nlm.nih.gov/15128856

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mice lacking p35, a neuronal specific activator of Cdk5, display cortical lamination defects, seizures, and adult lethality

1 reference

https://pubmed.ncbi.nlm.nih.gov/15128856

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cloning and characterization of Ras-GRF2, a novel guanine nucleotide exchange factor for Ras

1 reference

https://pubmed.ncbi.nlm.nih.gov/15128856

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Analysis of the expression, distribution and function of cyclin dependent kinase 5 (cdk5) in developing cerebellar macroneurons.

1 reference

https://pubmed.ncbi.nlm.nih.gov/15128856

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Activation of the exchange factor Ras-GRF by calcium requires an intact Dbl homology domain

1 reference

https://pubmed.ncbi.nlm.nih.gov/15128856

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Phosphorylation of human high molecular weight neurofilament protein (hNF-H) by neuronal cyclin-dependent kinase 5 (cdk5)

1 reference

https://pubmed.ncbi.nlm.nih.gov/15128856

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Study of proline-directed protein kinases involved in phosphorylation of the heavy neurofilament subunit.

1 reference

https://pubmed.ncbi.nlm.nih.gov/15128856

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Neurofilaments are part of the high molecular weight complex containing neuronal cdc2-like kinase (nclk).

1 reference

https://pubmed.ncbi.nlm.nih.gov/15128856

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Regulation of Munc-18/syntaxin 1A interaction by cyclin-dependent kinase 5 in nerve endings

1 reference

https://pubmed.ncbi.nlm.nih.gov/15128856

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Site-specific phosphorylation of Lys-Ser-Pro repeat peptides from neurofilament H by cyclin-dependent kinase 5: structural basis for substrate recognition

1 reference

https://pubmed.ncbi.nlm.nih.gov/15128856

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mitogen-activated protein kinases (Erk1,2) phosphorylate Lys-Ser-Pro (KSP) repeats in neurofilament proteins NF-H and NF-M.

1 reference

https://pubmed.ncbi.nlm.nih.gov/15128856

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cyclin-dependent kinase 5-deficient mice demonstrate novel developmental arrest in cerebral cortex

1 reference

https://pubmed.ncbi.nlm.nih.gov/15128856

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The exchange factor Ras-GRF2 activates Ras-dependent and Rac-dependent mitogen-activated protein kinase pathways

1 reference

https://pubmed.ncbi.nlm.nih.gov/15128856

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The p35/Cdk5 kinase is a neuron-specific Rac effector that inhibits Pak1 activity

1 reference

https://pubmed.ncbi.nlm.nih.gov/15128856

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Serine-23 is a major protein kinase A phosphorylation site on the amino-terminal head domain of the middle molecular mass subunit of neurofilament proteins

1 reference

https://pubmed.ncbi.nlm.nih.gov/15128856

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Regulation of exocytosis by cyclin-dependent kinase 5 via phosphorylation of Munc18

1 reference

https://pubmed.ncbi.nlm.nih.gov/15128856

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1523/JNEUROSCI.0690-04.2004

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6729444&resulttype=core&format=json

12 May 2020

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6729444&resulttype=core&format=json

12 May 2020

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6729444&resulttype=core&format=json

12 May 2020

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