Rapamycin confers preconditioning-like protection against ischemia-reperfusion injury in isolated mouse heart and cardiomyocytes (Q44920860)

7 December 2017

Rapamycin confers preconditioning-like protection against ischemia-reperfusion injury in isolated mouse heart and cardiomyocytes (English)

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7 December 2017

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4

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7 December 2017

Shakil Khan

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7 December 2017

Fadi Salloum

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7 December 2017

George W Vetrovec

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7 December 2017

Rakesh C Kukreja

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7 December 2017

1 August 2006

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Journal of Molecular and Cellular Cardiology

7 December 2017

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7 December 2017

41

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7 December 2017

256-264

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7 December 2017

2

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Preconditioning with ischemia: a delay of lethal cell injury in ischemic myocardium

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Preconditioning the Myocardium: From Cellular Physiology to Clinical Cardiology

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Pharmacological preconditioning with sildenafil: Basic mechanisms and clinical implications

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Myocardial protection at a crossroads: the need for translation into clinical therapy

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Prevention and treatment of allograft rejection in vivo by rapamycin: molecular and cellular mechanisms of action

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A randomized comparison of a sirolimus-eluting stent with a standard stent for coronary revascularization

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Cellular functions of immunophilins

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TOR, a central controller of cell growth

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Rapamycin-FKBP inhibits cell cycle regulators of proliferation in vascular smooth muscle cells

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The TOR signaling cascade regulates gene expression in response to nutrients

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FKBP12-rapamycin-associated protein associates with mitochondria and senses osmotic stress via mitochondrial dysfunction

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Akt maintains cell size and survival by increasing mTOR-dependent nutrient uptake

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Role of oral rapamycin to prevent restenosis in patients with de novo lesions undergoing coronary stenting: results of the Argentina single centre study (ORAR trial).

7 January 2021

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Sirolimus in de novo heart transplant recipients reduces acute rejection and prevents coronary artery disease at 2 years: a randomized clinical trial.

7 January 2021

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Immunophilins mediate the neuroprotective effects of FK506 in focal cerebral ischaemia

7 January 2021

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Second window of protection following myocardial preconditioning: an essential role for PI3 kinase and p70S6 kinase

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Myocardial protection by insulin at reperfusion requires early administration and is mediated via Akt and p70s6 kinase cell-survival signaling

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Cross-talk between the survival kinases during early reperfusion: its contribution to ischemic preconditioning

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Opioid-induced cardioprotection occurs via glycogen synthase kinase beta inhibition during reperfusion in intact rat hearts

7 January 2021

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Ischemic preconditioning in isolated perfused mouse heart: reduction in infarct size without improvement of post-ischemic ventricular function

7 January 2021

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Preconditioning limits mitochondrial Ca(2+) during ischemia in rat hearts: role of K(ATP) channels

7 January 2021

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Phosphodiesterase-5 inhibitor sildenafil preconditions adult cardiac myocytes against necrosis and apoptosis. Essential role of nitric oxide signaling.

7 January 2021

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Opening of Ca2+-activated K+ channels triggers early and delayed preconditioning against I/R injury independent of NOS in mice.

7 January 2021

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Mitochondrial K(ATP) channels in preconditioning

7 January 2021

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Mammalian target of rapamycin inhibitors activate the AKT kinase in multiple myeloma cells by up-regulating the insulin-like growth factor receptor/insulin receptor substrate-1/phosphatidylinositol 3-kinase cascade.

7 January 2021

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mTOR inhibition induces upstream receptor tyrosine kinase signaling and activates Akt

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Inhibition of PI-3 kinase/Akt/mTOR, but not calcineurin signaling, reverses insulin-like growth factor I-induced protection against glucose toxicity in cardiomyocyte contractile function

7 January 2021

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Distinct regulatory mechanism for p70 S6 kinase beta from that for p70 S6 kinase alpha

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Phosphorylation of mitochondrial elongation factor Tu in ischemic myocardium: basis for chloramphenicol-mediated cardioprotection

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p38 Triggers late preconditioning elicited by anisomycin in heart: involvement of NF-kappaB and iNOS.

7 January 2021

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Exogenous nitric oxide can trigger a preconditioned state through a free radical mechanism, but endogenous nitric oxide is not a trigger of classical ischemic preconditioning

7 January 2021

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Nitric oxide-cGMP-protein kinase G signaling pathway induces anoxic preconditioning through activation of ATP-sensitive K+ channels in rat hearts.

7 January 2021

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Aortic eNOS expression and phosphorylation in Apo-E knockout mice: differing effects of rapamycin and simvastatin.

7 January 2021

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High local production of nitric oxide as a possible mechanism by which rapamycin prevents transplant arteriosclerosis.

7 January 2021

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The ischemia-selective KATP channel antagonist, 5-hydroxydecanoate, blocks ischemic preconditioning in the rat heart

7 January 2021

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Mitochondrial ATP-dependent potassium channels. Viable candidate effectors of ischemic preconditioning.

7 January 2021

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KATP channels and myocardial preconditioning: an update

7 January 2021

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Evidence for mitochondrial K+ channels and their role in cardioprotection

7 January 2021

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Opioid-induced second window of cardioprotection: potential role of mitochondrial KATP channels

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Chemical preconditioning with 3-nitropropionic acid in hearts: role of mitochondrial K(ATP) channel

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Mitochondrial K(ATP) channel as an end effector of cardioprotection during late preconditioning: triggering role of nitric oxide

7 January 2021

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Sildenafil (Viagra) induces powerful cardioprotective effect via opening of mitochondrial K(ATP) channels in rabbits

7 January 2021

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Opening of mitochondrial K(ATP) channels triggers the preconditioned state by generating free radicals.

7 January 2021

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Diazoxide-induced cardioprotection requires signaling through a redox-sensitive mechanism

7 January 2021

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Reactive oxygen species released from mitochondria during brief hypoxia induce preconditioning in cardiomyocytes

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Targeting nucleotide-requiring enzymes: implications for diazoxide-induced cardioprotection

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Adenosine A1 receptor activation reduces reactive oxygen species and attenuates stunning in ventricular myocytes

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Activation of mitochondrial ATP-dependent potassium channels by nitric oxide.

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T-cadherin protects endothelial cells from oxidative stress-induced apoptosis

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mTOR inhibition reverses Akt-dependent prostate intraepithelial neoplasia through regulation of apoptotic and HIF-1-dependent pathways

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HER2 (neu) signaling increases the rate of hypoxia-inducible factor 1alpha (HIF-1alpha) synthesis: novel mechanism for HIF-1-mediated vascular endothelial growth factor expression

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Survival signalling by Akt and eIF4E in oncogenesis and cancer therapy

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Sustained activation of the JNK cascade and rapamycin-induced apoptosis are suppressed by p53/p21(Cip1)

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Rapamycin increases the cellular concentration of the BCL-2 protein and exerts an anti-apoptotic effect

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TSC2 mediates cellular energy response to control cell growth and survival

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Interferon alpha-induced apoptosis in tumor cells is mediated through the phosphoinositide 3-kinase/mammalian target of rapamycin signaling pathway

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Cell size reduction induced by inhibition of the mTOR/S6K-signaling pathway protects Jurkat cells from apoptosis

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Mitochondrial ATP-sensitive potassium channels inhibit apoptosis induced by oxidative stress in cardiac cells

7 January 2021

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Rapamycin (sirolimus) inhibits heart cell growth in vitro

7 January 2021

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Adult cardiac stem cells are multipotent and support myocardial regeneration

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CD31- but Not CD31+ cardiac side population cells exhibit functional cardiomyogenic differentiation

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Isolation and expansion of adult cardiac stem cells from human and murine heart

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Persistent expression of the ATP-binding cassette transporter, Abcg2, identifies cardiac SP cells in the developing and adult heart.

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Rapamycin-FKBP specifically blocks growth-dependent activation of and signaling by the 70 kd S6 protein kinases

7 January 2021

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Rapamycin-induced inhibition of the 70-kilodalton S6 protein kinase

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Specificity and mechanism of action of some commonly used protein kinase inhibitors

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Rapamycin attenuates load-induced cardiac hypertrophy in mice

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Rapamycin reverses chronic graft vascular disease in a novel cardiac allograft model

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10.1016/J.YJMCC.2006.04.014

7 January 2021

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7 December 2017

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