Evolution of a T7 RNA polymerase variant that transcribes 2'-O-methyl RNA. (Q45010727)

8 December 2017

Evolution of a T7 RNA polymerase variant that transcribes 2'-O-methyl RNA. (English)

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8 December 2017

Jijumon Chelliserrykattil

series ordinal

1

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PubMed ID

15300257

8 December 2017

Andrew D Ellington

series ordinal

2

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8 December 2017

8 August 2004

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8 December 2017

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8 December 2017

22

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8 December 2017

9

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8 December 2017

1155-1160

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https://scigraph.springernature.com/pub.10.1038/nbt1001

8 December 2017

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DNA polymerase active site is highly mutable: evolutionary consequences

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Multiple amino acid substitutions allow DNA polymerases to synthesize RNA.

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Directed evolution of novel polymerase activities: mutation of a DNA polymerase into an efficient RNA polymerase

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Expanding the substrate repertoire of a DNA polymerase by directed evolution

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2'-deoxycytidines carrying amino and thiol functionality: synthesis and incorporation by Vent (exo-) polymerase.

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An unnatural hydrophobic base, 4-propynylpyrrole-2-carbaldehyde, as an efficient pairing partner of 9-methylimidazo[(4,5)-b]pyridine.

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Enzymatic recognition of the base pair between isocytidine and isoguanosine

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A Y639F/H784A T7 RNA polymerase double mutant displays superior properties for synthesizing RNAs with non-canonical NTPs

21 January 2018

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Efficient synthesis of nucleic acids heavily modified with non-canonical ribose 2'-groups using a mutantT7 RNA polymerase (RNAP).

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Mechanism of ribose 2'-group discrimination by an RNA polymerase

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Structural basis for the transition from initiation to elongation transcription in T7 RNA polymerase

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Structural basis for substrate selection by t7 RNA polymerase.

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Antisense therapy for cancer--the time of truth

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Advantages of 2'-O-methyl oligoribonucleotide probes for detecting RNA targets

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What affects the effect of 2'-alkoxy modifications? 1. Stabilization effect of 2'-methoxy substitutions in uniformly modified DNA oligonucleotides

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Structural Determinants of Enzymic Processivity

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Kinetic Characterization of Ribonuclease-Resistant 2′-Modified Hammerhead Ribozymes

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7 January 2021

Expanding the genetic alphabet: non-epimerizing nucleoside with the pyDDA hydrogen-bonding pattern

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7 January 2021

An unnatural base pair for efficient incorporation of nucleotide analogs into RNAs

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7 January 2021

Roles of histidine 784 and tyrosine 639 in ribose discrimination by T7 RNA polymerase

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7 January 2021

A mutant T7 RNA polymerase as a DNA polymerase.

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7 January 2021

Template strand switching by T7 RNA polymerase

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7 January 2021

Identifiers

DOI

10.1038/NBT1001

1 reference

PubMed ID

15300257

Dimensions Publication ID

8 December 2017

0 references

1 reference

PubMed ID

15300257