A novel ubiquitin-like domain in IkappaB kinase beta is required for functional activity of the kinase (Q45023570)

8 December 2017

A novel ubiquitin-like domain in IkappaB kinase beta is required for functional activity of the kinase (English)

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8 December 2017

Michael J May

1

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author name string

Signe E Larsen

2

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8 December 2017

Jae Hyuck Shim

3

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8 December 2017

Lisa A Madge

4

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8 December 2017

Sankar Ghosh

5

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8 December 2017

language of work or name

English

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publication date

19 August 2004

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Journal of Biological Chemistry

8 December 2017

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8 December 2017

279

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8 December 2017

44

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8 December 2017

45528-45539

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Missing pieces in the NF-kappaB puzzle

8 December 2017

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M408579200

Phosphorylation meets ubiquitination: the control of NF-[kappa]B activity

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NF-kappa B and Rel proteins: evolutionarily conserved mediators of immune responses

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The IKK NF-kappa B system: a treasure trove for drug development

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IKK-1 and IKK-2: cytokine-activated IkappaB kinases essential for NF-kappaB activation

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IkappaB kinase (IKK)-associated protein 1, a common component of the heterogeneous IKK complex

21 January 2018

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IKK-gamma is an essential regulatory subunit of the IkappaB kinase complex

21 January 2018

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IkappaB kinase-beta: NF-kappaB activation and complex formation with IkappaB kinase-alpha and NIK

21 January 2018

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The IkappaB kinase complex (IKK) contains two kinase subunits, IKKalpha and IKKbeta, necessary for IkappaB phosphorylation and NF-kappaB activation

21 January 2018

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Severe liver degeneration in mice lacking the IkappaB kinase 2 gene

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The IKKbeta subunit of IkappaB kinase (IKK) is essential for nuclear factor kappaB activation and prevention of apoptosis

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Abnormal morphogenesis but intact IKK activation in mice lacking the IKKalpha subunit of IkappaB kinase

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Limb and skin abnormalities in mice lacking IKKalpha

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Female mice heterozygous for IKK gamma/NEMO deficiencies develop a dermatopathy similar to the human X-linked disorder incontinentia pigmenti

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The two NF-kappaB activation pathways and their role in innate and adaptive immunity

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IKKalpha provides an essential link between RANK signaling and cyclin D1 expression during mammary gland development

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Direct Phosphorylation of IB by IKK and IKK: Discrimination Between Free and NF-B-Bound Substrate

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A nucleosomal function for IkappaB kinase-alpha in NF-kappaB-dependent gene expression

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Histone H3 phosphorylation by IKK-alpha is critical for cytokine-induced gene expression

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Activation of the heterodimeric IkappaB kinase alpha (IKKalpha)-IKKbeta complex is directional: IKKalpha regulates IKKbeta under both basal and stimulated conditions

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IKKalpha, IKKbeta, and NEMO/IKKgamma are each required for the NF-kappa B-mediated inflammatory response program.

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The lymphotoxin-beta receptor induces different patterns of gene expression via two NF-kappaB pathways

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BAFF-induced NEMO-independent processing of NF-kappa B2 in maturing B cells.

21 January 2018

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Activation by IKKalpha of a second, evolutionary conserved, NF-kappa B signaling pathway

21 January 2018

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NF-kappaB-inducing kinase regulates the processing of NF-kappaB2 p100

21 January 2018

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CD40 regulates the processing of NF-kappaB2 p100 to p52

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IkappaB kinases: key regulators of the NF-kappaB pathway

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Characterization of the Ikappa B-kinase NEMO binding domain

21 January 2018

1 reference

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Selective inhibition of NF-kappaB activation by a peptide that blocks the interaction of NEMO with the IkappaB kinase complex

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The phosphorylation status of nuclear NF-kappa B determines its association with CBP/p300 or HDAC-1

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Integral UBL domain proteins: a family of proteasome interacting proteins.

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Characterization of the 2'-5'-oligoadenylate synthetase ubiquitin-like family

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p59OASL, a 2'-5' oligoadenylate synthetase like protein: a novel human gene related to the 2'-5' oligoadenylate synthetase family

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Structural determinants for the binding of ubiquitin-like domains to the proteasome

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Parkin binds the Rpn10 subunit of 26S proteasomes through its ubiquitin-like domain

21 January 2018

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Rad23 links DNA repair to the ubiquitin/proteasome pathway

21 January 2018

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Interaction of hHR23 with S5a. The ubiquitin-like domain of hHR23 mediates interaction with S5a subunit of 26 S proteasome

21 January 2018

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Structural studies of the interaction between ubiquitin family proteins and proteasome subunit S5a

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The elongin B ubiquitin homology domain. Identification of Elongin B sequences important for interaction with Elongin C.

21 January 2018

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Rad23 promotes the targeting of proteolytic substrates to the proteasome

21 January 2018

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Proteasome subunit Rpn1 binds ubiquitin-like protein domains

21 January 2018

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The Saccharomyces cerevisiae DNA repair gene RAD23 encodes a nuclear protein containing a ubiquitin-like domain required for biological function

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IKK beta plays an essential role in the phosphorylation of RelA/p65 on serine 536 induced by lipopolysaccharide

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IkappaB kinases phosphorylate NF-kappaB p65 subunit on serine 536 in the transactivation domain

21 January 2018

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Analysis of domains in the IKKalpha and IKKbeta proteins that regulate their kinase activity

21 January 2018

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Complete reconstitution of human IkappaB kinase (IKK) complex in yeast. Assessment of its stoichiometry and the role of IKKgamma on the complex activity in the absence of stimulation

21 January 2018

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Structure of the Ubiquitin-interacting Motif of S5a Bound to the Ubiquitin-like Domain of HR23B

21 January 2018

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Budding yeast Dsk2p is a polyubiquitin-binding protein that can interact with the proteasome

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Binding surface mapping of intra- and interdomain interactions among hHR23B, ubiquitin, and polyubiquitin binding site 2 of S5a

21 January 2018

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Identification of ubiquitin-like protein-binding subunits of the 26S proteasome

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Ubiquitin recognition by the DNA repair protein hHR23a.

21 January 2018

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CSN3 interacts with IKKgamma and inhibits TNF- but not IL-1-induced NF-kappaB activation

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21 January 2018

Identifiers

DOI

10.1074/JBC.M408579200

1 reference

release_oxx5t7tixrfdpezezhhid2sn3m

8 December 2017

1 reference

Fatcat

https://api.fatcat.wiki/v0/release/oxx5t7tixrfdpezezhhid2sn3m

mapped directly with Wikidata item

24 November 2022

based on heuristic

1 reference