Islet-Derived CD4 T Cells Targeting Proinsulin in Human Autoimmune Diabetes (Q45048293)

18 May 2018

title

Islet-Derived CD4 T Cells Targeting Proinsulin in Human Autoimmune Diabetes (English)

1 reference

18 May 2018

9

John W Kappler

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18 May 2018

6

William W Kwok

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18 May 2018

author name string

Aaron W Michels

1

1 reference

18 May 2018

Laurie G Landry

2

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18 May 2018

Kristen A McDaniel

3

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18 May 2018

Liping Yu

4

1 reference

18 May 2018

Martha Campbell-Thompson

5

1 reference

18 May 2018

Kenneth L Jones

7

1 reference

18 May 2018

Peter A Gottlieb

8

1 reference

18 May 2018

Qizhi Tang

10

1 reference

18 May 2018

Bart O Roep

11

1 reference

18 May 2018

Mark A Atkinson

12

1 reference

18 May 2018

Clayton E Mathews

13

1 reference

18 May 2018

Maki Nakayama

14

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18 May 2018

language of work or name

English

0 references

publication date

5 December 2016

1 reference

18 May 2018

published in

Diabetes

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18 May 2018

volume

66

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18 May 2018

issue

3

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18 May 2018

page(s)

722-734

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18 May 2018

Pathogenic CD4 T cells in type 1 diabetes recognize epitopes formed by peptide fusion

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25 May 2018

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25 May 2018

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25 May 2018

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Autoreactive T cells specific for insulin B:11-23 recognize a low-affinity peptide register in human subjects with autoimmune diabetes

25 May 2018

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Seroconversion to multiple islet autoantibodies and risk of progression to diabetes in children

25 May 2018

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Immune therapy in type 1 diabetes mellitus

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Human β-cell killing by autoreactive preproinsulin-specific CD8 T cells is predominantly granule-mediated with the potency dependent upon T-cell receptor avidity

25 May 2018

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Structure-based selection of small molecules to alter allele-specific MHC class II antigen presentation

25 May 2018

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Specificity and detection of insulin-reactive CD4+ T cells in type 1 diabetes in the nonobese diabetic (NOD) mouse

25 May 2018

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Affinity maturation of human CD4 by yeast surface display and crystal structure of a CD4-HLA-DR1 complex

25 May 2018

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Evidence that nasal insulin induces immune tolerance to insulin in adults with autoimmune diabetes

25 May 2018

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Unique autoreactive T cells recognize insulin peptides generated within the islets of Langerhans in autoimmune diabetes

25 May 2018

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Incidence trends for childhood type 1 diabetes in Europe during 1989-2003 and predicted new cases 2005-20: a multicentre prospective registration study

25 May 2018

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25 May 2018

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HLA DR-DQ haplotypes and genotypes and type 1 diabetes risk: analysis of the type 1 diabetes genetics consortium families

25 May 2018

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Responses against islet antigens in NOD mice are prevented by tolerance to proinsulin but not IGRP.

25 May 2018

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HLA-DQ2 and -DQ8 signatures of gluten T cell epitopes in celiac disease

25 May 2018

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The insulin A-chain epitope recognized by human T cells is posttranslationally modified

25 May 2018

1 reference

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Natural peptides selected by diabetogenic DQ8 and murine I-A(g7) molecules show common sequence specificity

25 May 2018

1 reference

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Prime role for an insulin epitope in the development of type 1 diabetes in NOD mice

25 May 2018

1 reference

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Development of autoimmune diabetes in glutamic acid decarboxylase 65 (GAD65) knockout NOD mice.

25 May 2018

1 reference

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Structure of a human insulin peptide-HLA-DQ8 complex and susceptibility to type 1 diabetes

25 May 2018

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A disease-associated cellular immune response in type 1 diabetics to an immunodominant epitope of insulin

25 May 2018

1 reference

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A structural framework for deciphering the link between I-Ag7 and autoimmune diabetes

25 May 2018

1 reference

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The insulin gene is transcribed in the human thymus and transcription levels correlated with allelic variation at the INS VNTR-IDDM2 susceptibility locus for type 1 diabetes.

25 May 2018

1 reference

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Antigen recognition properties of mutant V beta 3+ T cell receptors are consistent with an immunoglobulin-like structure for the receptor

25 May 2018

1 reference

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Genetic and pathogenic basis of autoimmune diabetes in NOD mice

25 May 2018

1 reference

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Epitope specificity, cytokine production profile and diabetogenic activity of insulin-specific T cell clones isolated from NOD mice

25 May 2018

1 reference

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Rapid typing of HLA-DQB1 DNA polymorphism using nonradioactive oligonucleotide probes and amplified DNA.

25 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5319719

Effects of oral insulin in relatives of patients with type 1 diabetes: The Diabetes Prevention Trial--Type 1.

25 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5319719

GAD65-specific CD4+ T-cells with high antigen avidity are prevalent in peripheral blood of patients with type 1 diabetes

15 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5319719

IA-2 is not required for the development of diabetes in NOD mice

15 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5319719

Effects of insulin in relatives of patients with type 1 diabetes mellitus

15 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5319719

Proinsulin-Specific, HLA-DQ8, and HLA-DQ8-Transdimer–Restricted CD4+T Cells Infiltrate Islets in Type 1 Diabetes

15 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5319719

Insulin VNTR allele-specific effect in type 1 diabetes depends on identity of untransmitted paternal allele

1 December 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5319719

Expanded T cells from pancreatic lymph nodes of type 1 diabetic subjects recognize an insulin epitope

1 December 2018

1 reference

12 December 2020

Nasal insulin to prevent type 1 diabetes in children with HLA genotypes and autoantibodies conferring increased risk of disease: a double-blind, randomised controlled trial

1 reference

12 December 2020

Complex regulation of class II gene expression: analysis with class II mutant cell lines

1 reference

12 December 2020

Immunomodulation in type 1 diabetes by NBI-6024, an altered peptide ligand of the insulin B epitope

1 reference

12 December 2020

Transgenic expression of mouse proinsulin II prevents diabetes in nonobese diabetic mice

1 reference

12 December 2020

Antiislet autoantibodies usually develop sequentially rather than simultaneously

1 reference

12 December 2020

Recessive tolerance to preproinsulin 2 reduces but does not abolish type 1 diabetes

1 reference

12 December 2020

Posttranslational Modification of HLA-DQ Binding Islet Autoantigens in Type 1 Diabetes

1 reference

12 December 2020

Functional consequences of HLA-DQ8 homozygosity versus heterozygosity for islet autoimmunity in type 1 diabetes

1 reference

12 December 2020

Identifiers

DOI

10.2337/DB16-1025

1 reference

18 May 2018

PMC publication ID

5319719

1 reference

18 May 2018

PubMed publication ID

27920090

1 reference

18 May 2018