mTORC1 promotes denervation-induced muscle atrophy through a mechanism involving the activation of FoxO and E3 ubiquitin ligases (Q45084079)

9 December 2017

mTORC1 promotes denervation-induced muscle atrophy through a mechanism involving the activation of FoxO and E3 ubiquitin ligases (English)

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9 December 2017

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Ronald A DePinho

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9 December 2017

Huibin Tang

1

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9 December 2017

Ken Inoki

2

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9 December 2017

Myung Lee

3

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9 December 2017

Erika Wright

4

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9 December 2017

Andy Khuong

5

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9 December 2017

Amanda Khuong

6

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9 December 2017

Sista Sugiarto

7

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9 December 2017

Matthew Garner

8

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9 December 2017

Jihye Paik

9

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9 December 2017

Daniel Goldman

11

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9 December 2017

Kun-Liang Guan

12

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9 December 2017

Joseph B Shrager

13

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9 December 2017

language of work or name

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25 February 2014

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9 December 2017

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9 December 2017

7

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9 December 2017

314

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9 December 2017

ra18

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Motor neuron disease: systematic reviews of treatment for ALS and SMA.

9 December 2017

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2004809

Motor neuron diversity in development and disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2004809

Cellular and molecular mechanisms of muscle atrophy

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2004809

PI3 kinase regulation of skeletal muscle hypertrophy and atrophy

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2004809

Recent progress toward understanding the molecular mechanisms that regulate skeletal muscle mass

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2004809

Systems biology of skeletal muscle: fiber type as an organizing principle

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2004809

Mechanisms of muscle wasting. The role of the ubiquitin-proteasome pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2004809

The molecular basis of skeletal muscle atrophy

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2004809

Identification of ubiquitin ligases required for skeletal muscle atrophy

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2004809

Atrogin-1, a muscle-specific F-box protein highly expressed during muscle atrophy

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2004809

Multiple types of skeletal muscle atrophy involve a common program of changes in gene expression

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2004809

The histone deacetylase HDAC4 connects neural activity to muscle transcriptional reprogramming

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2004809

Activity-dependent gene regulation in skeletal muscle is mediated by a histone deacetylase (HDAC)-Dach2-myogenin signal transduction cascade

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2004809

A histone deacetylase 4/myogenin positive feedback loop coordinates denervation-dependent gene induction and suppression

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2004809

Myogenin and class II HDACs control neurogenic muscle atrophy by inducing E3 ubiquitin ligases

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2004809

Myogenin regulates denervation-dependent muscle atrophy in mouse soleus muscle

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2004809

Foxo transcription factors induce the atrophy-related ubiquitin ligase atrogin-1 and cause skeletal muscle atrophy

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2004809

Skeletal muscle FOXO1 (FKHR) transgenic mice have less skeletal muscle mass, down-regulated Type I (slow twitch/red muscle) fiber genes, and impaired glycemic control

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2004809

FOXO signaling is required for disuse muscle atrophy and is directly regulated by Hsp70

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2004809

Inhibition of FoxO transcriptional activity prevents muscle fiber atrophy during cachexia and induces hypertrophy

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2004809

A unifying model for mTORC1-mediated regulation of mRNA translation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2004809

mTOR signaling in growth control and disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2004809

mTOR signaling in disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2004809

Defining the role of mTOR in cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2004809

The translational landscape of mTOR signalling steers cancer initiation and metastasis

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2004809

Skeletal muscle-specific ablation of raptor, but not of rictor, causes metabolic changes and results in muscle dystrophy

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2004809

Regulation of mTOR complex 1 (mTORC1) by raptor Ser863 and multisite phosphorylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2004809

mTORC1 activation in podocytes is a critical step in the development of diabetic nephropathy in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2004809

Muscle inactivation of mTOR causes metabolic and dystrophin defects leading to severe myopathy

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2004809

Muscle atrophy in transgenic mice expressing a human TSC1 transgene

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2004809

S6 kinase deletion suppresses muscle growth adaptations to nutrient availability by activating AMP kinase.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2004809

Intracellular signaling pathways regulating net protein balance following diaphragm muscle denervation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2004809

mTOR and cancer: insights into a complex relationship

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2004809

S6K directly phosphorylates IRS-1 on Ser-270 to promote insulin resistance in response to TNF-(alpha) signaling through IKK2

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2004809

Mammalian target of rapamycin pathway regulates insulin signaling via subcellular redistribution of insulin receptor substrate 1 and integrates nutritional signals and metabolic signals of insulin

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2004809

Amino acid and insulin signaling via the mTOR/p70 S6 kinase pathway. A negative feedback mechanism leading to insulin resistance in skeletal muscle cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2004809

The mTOR/PI3K and MAPK pathways converge on eIF4B to control its phosphorylation and activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2004809

Inhibition of cap-dependent translation via phosphorylation of eIF4G by protein kinase Pak2

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2004809

Mechanotransduction and the regulation of mTORC1 signaling in skeletal muscle

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2004809

The role of phospholipase D and phosphatidic acid in the mechanical activation of mTOR signaling in skeletal muscle

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2004809

Differential response of skeletal muscles to mTORC1 signaling during atrophy and hypertrophy.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2004809

Sustained activation of mTORC1 in skeletal muscle inhibits constitutive and starvation-induced autophagy and causes a severe, late-onset myopathy

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2004809

mTOR pathway as a target in tissue hypertrophy.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2004809

Developmental regulation of the activation of signaling components leading to translation initiation in skeletal muscle of neonatal pigs.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2004809

Akt/mTOR pathway is a crucial regulator of skeletal muscle hypertrophy and can prevent muscle atrophy in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2004809

Rapamycin fed late in life extends lifespan in genetically heterogeneous mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2004809

Rapamycin treatment augments motor neuron degeneration in SOD1(G93A) mouse model of amyotrophic lateral sclerosis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2004809

The IGF-1/PI3K/Akt pathway prevents expression of muscle atrophy-induced ubiquitin ligases by inhibiting FOXO transcription factors

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2004809

Regulation of skeletal muscle growth by the IGF1-Akt/PKB pathway: insights from genetic models

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2004809

Transgenic overexpression of locally acting insulin-like growth factor-1 inhibits ubiquitin-mediated muscle atrophy in chronic left-ventricular dysfunction

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2004809

Mediation of IGF-1-induced skeletal myotube hypertrophy by PI(3)K/Akt/mTOR and PI(3)K/Akt/GSK3 pathways.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2004809

Myogenin gene disruption results in perinatal lethality because of severe muscle defect

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2004809

Muscle deficiency and neonatal death in mice with a targeted mutation in the myogenin gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2004809

Loss of myogenin in postnatal life leads to normal skeletal muscle but reduced body size.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2004809

The mTOR-regulated phosphoproteome reveals a mechanism of mTORC1-mediated inhibition of growth factor signaling.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2004809

Phosphoproteomic analysis identifies Grb10 as an mTORC1 substrate that negatively regulates insulin signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2004809

Disruption of forkhead transcription factor (FOXO) family members in mice reveals their functional diversification

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2004809

Astrocyte-specific TSC1 conditional knockout mice exhibit abnormal neuronal organization and seizures.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2004809

FoxOs are lineage-restricted redundant tumor suppressors and regulate endothelial cell homeostasis

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2004809

S6 kinase inactivation impairs growth and translational target phosphorylation in muscle cells maintaining proper regulation of protein turnover

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2004809

10.1126/SCISIGNAL.2004809

21 January 2018

Identifiers

DOI

1 reference

9 December 2017

1 reference