[6]-Gingerol inhibits COX-2 expression by blocking the activation of p38 MAP kinase and NF-kappaB in phorbol ester-stimulated mouse skin (Q45286157)

11 December 2017

[6]-Gingerol inhibits COX-2 expression by blocking the activation of p38 MAP kinase and NF-kappaB in phorbol ester-stimulated mouse skin (English)

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11 December 2017

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7

Young-Joon Surh

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11 December 2017

5

Myung-Haing Cho

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11 December 2017

Sue Ok Kim

1

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11 December 2017

Joydeb Kumar Kundu

2

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11 December 2017

Young Kee Shin

3

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11 December 2017

Jin-Hong Park

4

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11 December 2017

Tae-Yoon Kim

6

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11 December 2017

language of work or name

English

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publication date

1 April 2005

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2558-2567

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https://scigraph.springernature.com/pub.10.1038/sj.onc.1208446

11 December 2017

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Akt stimulates the transactivation potential of the RelA/p65 Subunit of NF-kappa B through utilization of the Ikappa B kinase and activation of the mitogen-activated protein kinase p38.

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Activation of NFkappaB is necessary for IL-1beta-induced cyclooxygenase-2 (COX-2) expression in human gingival fibroblasts

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IkappaB kinases phosphorylate NF-kappaB p65 subunit on serine 536 in the transactivation domain

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Distinct roles of the Ikappa B kinase alpha and beta subunits in liberating nuclear factor kappa B (NF-kappa B) from Ikappa B and in phosphorylating the p65 subunit of NF-kappa B.

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Activation of nuclear factor-kappaB-dependent transcription by tumor necrosis factor-alpha is mediated through phosphorylation of RelA/p65 on serine 529.

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Activation of transcription factor NF-kappaB and p38 mitogen-activated protein kinase is mediated by distinct and separate stress effector pathways

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IKK beta plays an essential role in the phosphorylation of RelA/p65 on serine 536 induced by lipopolysaccharide

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Curcumin inhibits phorbol ester-induced expression of cyclooxygenase-2 in mouse skin through suppression of extracellular signal-regulated kinase activity and NF-kappaB activation

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At the crossroads of inflammation and cancer

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Missing pieces in the NF-kappaB puzzle

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Requirement for glycogen synthase kinase-3beta in cell survival and NF-kappaB activation

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How NF-kappaB is activated: the role of the IkappaB kinase (IKK) complex

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Roles of histone acetyltransferases and deacetylases in gene regulation

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Suppression of inducible nitric oxide synthase and cyclooxygenase-2 in downregulating nuclear factor-kappa B pathway by Garcinol

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Inhibition of 12-O-tetradecanoylphorbol-13-acetate-induced NF-kappaB activation by tea polyphenols, (-)-epigallocatechin gallate and theaflavins

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NF-kappaB functions as a tumour promoter in inflammation-associated cancer

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The role of cyclooxygenases in inflammation, cancer, and development

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Identifiers

DOI

10.1038/SJ.ONC.1208446

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Dimensions Publication ID

11 December 2017

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1 reference