Oxidizing effects of exogenous stressors in Huntington's disease knock-in striatal cells--protective effect of cystamine and creatine (Q45294879)

11 December 2017

title

Oxidizing effects of exogenous stressors in Huntington's disease knock-in striatal cells--protective effect of cystamine and creatine (English)

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11 December 2017

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3

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12 June 2020

Ana Silva

2

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12 June 2020

Luana Naia

4

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12 June 2020

Ana Cristina Rego

5

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12 June 2020

author name string

Márcio Ribeiro

1

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12 June 2020

publication date

5 September 2013

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11 December 2017

published in

Toxicological Sciences

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12 June 2020

volume

136

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12 June 2020

issue

2

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12 June 2020

page(s)

487-499

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Mice with a partial deficiency of manganese superoxide dismutase show increased vulnerability to the mitochondrial toxins malonate, 3-nitropropionic acid, and MPTP.

12 June 2020

cites work

1 reference

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The protective effects of cystamine in the R6/2 Huntington's disease mouse involve mechanisms other than the inhibition of tissue transglutaminase

21 January 2018

1 reference

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Transglutaminase inhibition protects against oxidative stress-induced neuronal death downstream of pathological ERK activation

21 January 2018

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Kynurenic acid concentrations are reduced in Huntington's disease cerebral cortex

21 January 2018

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Oxidative damage and metabolic dysfunction in Huntington's disease: selective vulnerability of the basal ganglia.

21 January 2018

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Cystamine protects from 3-nitropropionic acid lesioning via induction of nf-e2 related factor 2 mediated transcription

21 January 2018

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Increased oxidative damage and mitochondrial abnormalities in the peripheral blood of Huntington's disease patients

21 January 2018

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Tumour suppressor SIRT3 deacetylates and activates manganese superoxide dismutase to scavenge ROS

21 January 2018

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Increased glutathione levels in cortical and striatal mitochondria of the R6/2 Huntington's disease mouse model

21 January 2018

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Morphologic and histochemical characteristics of a spared subset of striatal neurons in Huntington's disease

21 January 2018

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Mitochondrial-dependent apoptosis in Huntington's disease human cybrids.

21 January 2018

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Cystamine increases L-cysteine levels in Huntington's disease transgenic mouse brain and in a PC12 model of polyglutamine aggregation

21 January 2018

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trans-(-)-ε-Viniferin increases mitochondrial sirtuin 3 (SIRT3), activates AMP-activated protein kinase (AMPK), and protects cells in models of Huntington Disease

21 January 2018

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Cytosolic and mitochondrial ROS in staurosporine-induced retinal cell apoptosis.

21 January 2018

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Oxidative stress promotes mutant huntingtin aggregation and mutant huntingtin-dependent cell death by mimicking proteasomal malfunction.

21 January 2018

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Creatine in Huntington disease is safe, tolerable, bioavailable in brain and reduces serum 8OH2'dG.

21 January 2018

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Phosphorylation of Nrf2 at Ser-40 by protein kinase C regulates antioxidant response element-mediated transcription

21 January 2018

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1H NMR spectroscopy studies of Huntington's disease: correlations with CAG repeat numbers

21 January 2018

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Impaired mitochondrial dynamics and Nrf2 signaling contribute to compromised responses to oxidative stress in striatal cells expressing full-length mutant huntingtin

21 January 2018

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Transglutaminase action imitates Huntington's disease: selective polymerization of Huntingtin containing expanded polyglutamine.

21 January 2018

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Peptides containing glutamine repeats as substrates for transglutaminase-catalyzed cross-linking: relevance to diseases of the nervous system

21 January 2018

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Measuring reactive oxygen and nitrogen species with fluorescent probes: challenges and limitations

21 January 2018

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Prolonged survival and decreased abnormal movements in transgenic model of Huntington disease, with administration of the transglutaminase inhibitor cystamine

21 January 2018

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Cytochrome C and caspase-9 expression in Huntington's disease

21 January 2018

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Mitochondrial loss, dysfunction and altered dynamics in Huntington's disease

21 January 2018

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Direct antioxidant properties of creatine

21 January 2018

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Cystamine inhibits caspase activity. Implications for the treatment of polyglutamine disorders

21 January 2018

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Validation of lucigenin (bis-N-methylacridinium) as a chemilumigenic probe for detecting superoxide anion radical production by enzymatic and cellular systems

21 January 2018

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Neural stem/progenitor cells initiate the formation of cellular networks that provide neuroprotection by growth factor-modulated antioxidant expression

21 January 2018

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Mitochondrial respiration and ATP production are significantly impaired in striatal cells expressing mutant huntingtin

21 January 2018

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Early alterations of brain cellular energy homeostasis in Huntington disease models

21 January 2018

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Investigation of the Alamar Blue (resazurin) fluorescent dye for the assessment of mammalian cell cytotoxicity.

21 January 2018

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Increased formation of reactive oxygen species, but no changes in glutathione peroxidase activity, in striata of mice transgenic for the Huntington's disease mutation

21 January 2018

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Glutathione redox cycle dysregulation in Huntington's disease knock-in striatal cells.

21 January 2018

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The selective detection of mitochondrial superoxide by live cell imaging

21 January 2018

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FK506 ameliorates cell death features in Huntington's disease striatal cell models.

21 January 2018

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Comparative analysis of superoxide dismutase activity between acute pharmacological models and a transgenic mouse model of Huntington's disease

21 January 2018

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Proteomic and oxidative stress analysis in human brain samples of Huntington disease.

21 January 2018

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Tryptophan metabolism and oxidative stress in patients with Huntington's disease

21 January 2018

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Staurosporine, a potent inhibitor of phospholipid/Ca++dependent protein kinase

21 January 2018

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A novel gene containing a trinucleotide repeat that is expanded and unstable on Huntington's disease chromosomes.

21 January 2018

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Neurochemical changes in Huntington R6/2 mouse striatum detected by in vivo 1H NMR spectroscopy

21 January 2018

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Dominant phenotypes produced by the HD mutation in STHdh(Q111) striatal cells

21 January 2018

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Transcranial magnetic stimulation attenuates cell loss and oxidative damage in the striatum induced in the 3-nitropropionic model of Huntington's disease

21 January 2018

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Formation of a supplemental long time-constant reservoir of high energy phosphate by brain in vivo and in vitro and its reversible depletion by potassium depolarization

21 January 2018

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Combination therapy with coenzyme Q10 and creatine produces additive neuroprotective effects in models of Parkinson's and Huntington's diseases

21 January 2018

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Mediation of poly(ADP-ribose) polymerase-1-dependent cell death by apoptosis-inducing factor

21 January 2018

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