Activation of Wnt signaling by lithium and rosiglitazone reduced spatial memory impairment and neurodegeneration in brains of an APPswe/PSEN1DeltaE9 mouse model of Alzheimer's disease. (Q45924406)

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scientific article published on 21 July 2009

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English	Activation of Wnt signaling by lithium and rosiglitazone reduced spatial memory impairment and neurodegeneration in brains of an APPswe/PSEN1DeltaE9 mouse model of Alzheimer's disease.	scientific article published on 21 July 2009

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scholarly article

1 reference

Europe PubMed Central

PubMed publication ID

17 December 2017

http://europepmc.org/abstract/MED/19621015

Activation of Wnt signaling by lithium and rosiglitazone reduced spatial memory impairment and neurodegeneration in brains of an APPswe/PSEN1DeltaE9 mouse model of Alzheimer's disease. (English)

1 reference

Europe PubMed Central

PubMed publication ID

17 December 2017

http://europepmc.org/abstract/MED/19621015

Alzheimer's disease

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1 reference

based on heuristic

inferred from title

(RS)-rosiglitazone

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based on heuristic

inferred from title

neurodegeneration

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based on heuristic

inferred from title

Enrique M Toledo

1

1 reference

Europe PubMed Central

PubMed publication ID

17 December 2017

http://europepmc.org/abstract/MED/19621015

author name string

N C Inestrosa

2

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Europe PubMed Central

PubMed publication ID

17 December 2017

http://europepmc.org/abstract/MED/19621015

language of work or name

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publication date

21 July 2009

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Europe PubMed Central

PubMed publication ID

17 December 2017

http://europepmc.org/abstract/MED/19621015

Molecular Psychiatry

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Europe PubMed Central

PubMed publication ID

17 December 2017

http://europepmc.org/abstract/MED/19621015

15

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Europe PubMed Central

PubMed publication ID

17 December 2017

http://europepmc.org/abstract/MED/19621015

3

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Europe PubMed Central

PubMed publication ID

17 December 2017

http://europepmc.org/abstract/MED/19621015

272-85, 228

1 reference

Europe PubMed Central

PubMed publication ID

17 December 2017

http://europepmc.org/abstract/MED/19621015

Physical basis of cognitive alterations in alzheimer's disease: Synapse loss is the major correlate of cognitive impairment

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Alzheimer's disease is a synaptic failure

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The role of Wnt signaling in neuronal dysfunction in Alzheimer's Disease

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Amyloid-beta protein dimers isolated directly from Alzheimer's brains impair synaptic plasticity and memory

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Glycogen synthase kinase-3beta facilitates staurosporine- and heat shock-induced apoptosis. Protection by lithium

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Regulation of tau phosphorylation and protection against beta-amyloid-induced neurodegeneration by lithium. Possible implications for Alzheimer's disease

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A molecular mechanism for the effect of lithium on development

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Inhibition of glycogen synthase kinase-3 by lithium correlates with reduced tauopathy and degeneration in vivo

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Neuroprotective effects of regulators of the glycogen synthase kinase-3beta signaling pathway in a transgenic model of Alzheimer's disease are associated with reduced amyloid precursor protein phosphorylation.

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Activation of Wnt signaling rescues neurodegeneration and behavioral impairments induced by beta-amyloid fibrils

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GSK-3alpha regulates production of Alzheimer's disease amyloid-beta peptides

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Lithium, a common drug for bipolar disorder treatment, regulates amyloid-beta precursor protein processing

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Peroxisome proliferator-activated receptor agonists.

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Peroxisome-proliferator-activated receptor gamma induces a clearance mechanism for the amyloid-beta peptide.

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Peroxisome proliferator-activated receptor gamma is expressed in hippocampal neurons and its activation prevents beta-amyloid neurodegeneration: role of Wnt signaling.

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Inhibition of the canonical Wnt signaling pathway by apolipoprotein E4 in PC12 cells

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Insulin resistance contributes to aberrant stress responses in the Tg2576 mouse model of Alzheimer's disease

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Rosiglitazone increases dendritic spine density and rescues spine loss caused by apolipoprotein E4 in primary cortical neurons

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Mutant presenilins specifically elevate the levels of the 42 residue beta-amyloid peptide in vivo: evidence for augmentation of a 42-specific gamma secretase

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Acetylcholinesterase induces neuronal cell loss, astrocyte hypertrophy and behavioral deficits in mammalian hippocampus

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STI571 prevents apoptosis, tau phosphorylation and behavioural impairments induced by Alzheimer's beta-amyloid deposits

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A learning deficit related to age and beta-amyloid plaques in a mouse model of Alzheimer's disease

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Acetylcholinesterase-Abeta complexes are more toxic than Abeta fibrils in rat hippocampus: effect on rat beta-amyloid aggregation, laminin expression, reactive astrocytosis, and neuronal cell loss

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Beta-sheet breaker peptide prevents Abeta-induced spatial memory impairments with partial reduction of amyloid deposits

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The fluorescent Congo red derivative, (trans, trans)-1-bromo-2,5-bis-(3-hydroxycarbonyl-4-hydroxy)styrylbenzene (BSB), labels diverse beta-pleated sheet structures in postmortem human neurodegenerative disease brains

1 reference

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Identification of PSD-95 as a regulator of dopamine-mediated synaptic and behavioral plasticity

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Wnt-3a overcomes beta-amyloid toxicity in rat hippocampal neurons.

1 reference

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Induction of cellular prion protein gene expression by copper in neurons

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Wnt-5a/JNK signaling promotes the clustering of PSD-95 in hippocampal neurons.

1 reference

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Cyclohexanehexol inhibitors of Abeta aggregation prevent and reverse Alzheimer phenotype in a mouse model.

1 reference

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Characterization of amyloid deposition in the APPswe/PS1dE9 mouse model of Alzheimer disease

1 reference

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Pharmacology and Toxicology of Lithium

1 reference

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AMPA receptor downscaling at the onset of Alzheimer's disease pathology in double knockin mice.

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Episodic-like memory in animals: psychological criteria, neural mechanisms and the value of episodic-like tasks to investigate animal models of neurodegenerative disease

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Synaptotoxicity in Alzheimer's disease: the Wnt signaling pathway as a molecular target

1 reference

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Synaptic targeting by Alzheimer's-related amyloid beta oligomers.

1 reference

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Naturally secreted oligomers of amyloid beta protein potently inhibit hippocampal long-term potentiation in vivo

1 reference

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A Oligomer-Induced Aberrations in Synapse Composition, Shape, and Density Provide a Molecular Basis for Loss of Connectivity in Alzheimer's Disease

1 reference

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Triple-transgenic model of Alzheimer's disease with plaques and tangles: intracellular Abeta and synaptic dysfunction

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Widespread changes in dendritic spines in a model of Alzheimer's disease.

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Common structure of soluble amyloid oligomers implies common mechanism of pathogenesis

1 reference

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Trolox and 17beta-estradiol protect against amyloid beta-peptide neurotoxicity by a mechanism that involves modulation of the Wnt signaling pathway

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Beta-amyloid oligomers affect the structure and function of the postsynaptic region: role of the Wnt signaling pathway

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Lithium therapy and signal transduction.

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Lithium: potential therapeutics against acute brain injuries and chronic neurodegenerative diseases

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Lithium inhibits glycogen synthase kinase-3 activity and mimics wingless signalling in intact cells

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Lithium inhibits Alzheimer's disease-like tau protein phosphorylation in neurons

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Lithium reduces tau phosphorylation but not A beta or working memory deficits in a transgenic model with both plaques and tangles

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PPARgamma agonists as new therapeutic agents for the treatment of Alzheimer's disease

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Peroxisome proliferator-activated receptor gamma up-regulates the Bcl-2 anti-apoptotic protein in neurons and induces mitochondrial stabilization and protection against oxidative stress and apoptosis.

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Characterization of mouse dishevelled (Dvl) proteins in Wnt/Wingless signaling pathway

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Purified Wnt-5a increases differentiation of midbrain dopaminergic cells and dishevelled phosphorylation

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Wnt signaling in neuroprotection and stem cell differentiation

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Clearance of Alzheimer's Abeta peptide: the many roads to perdition.

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Matrix metalloproteinases expressed by astrocytes mediate extracellular amyloid-beta peptide catabolism.

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Wnt signaling induces matrix metalloproteinase expression and regulates T cell transmigration

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Beta-amyloid accumulation in APP mutant neurons reduces PSD-95 and GluR1 in synapses

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Soluble beta-amyloid1-40 induces NMDA-dependent degradation of postsynaptic density-95 at glutamatergic synapses.

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Wnt-7a modulates the synaptic vesicle cycle and synaptic transmission in hippocampal neurons.

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Efficacy of rosiglitazone in a genetically defined population with mild-to-moderate Alzheimer's disease

1 reference

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Protein kinase C inhibits amyloid beta peptide neurotoxicity by acting on members of the Wnt pathway.

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M1 muscarinic receptor activation protects neurons from beta-amyloid toxicity. A role for Wnt signaling pathway

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Glycogen synthase kinase-3: a putative molecular target for lithium mimetic drugs

1 reference

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inferred from DOI database lookup

Chronic lithium treatment decreases mutant tau protein aggregation in a transgenic mouse model.

1 reference

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Fibrous Astrocytes in senile dementia of the Alzheimer type.

1 reference

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Identifiers

10.1038/MP.2009.72

1 reference

Europe PubMed Central

PubMed publication ID

17 December 2017

http://europepmc.org/abstract/MED/19621015

Dimensions Publication ID

0 references

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

17 December 2017

http://europepmc.org/abstract/MED/19621015

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