S655 phosphorylation enhances APP secretory traffic (Q46043117)

19 December 2017

title

S655 phosphorylation enhances APP secretory traffic (English)

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19 December 2017

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1

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19 December 2017

Sandra Rebelo

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19 December 2017

author name string

Sara Catarina Domingues

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19 December 2017

Edgar F da Cruz e Silva

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19 December 2017

Odete A B da Cruz e Silva

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19 December 2017

publication date

21 April 2009

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19 December 2017

Molecular and Cellular Biochemistry

published in

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19 December 2017

volume

328

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19 December 2017

issue

1-2

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19 December 2017

page(s)

145-154

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19 December 2017

https://scigraph.springernature.com/pub.10.1007/s11010-009-0084-7

exact match

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cites work

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Phosphorylation-induced structural changes in the amyloid precursor protein cytoplasmic tail detected by NMR.

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Ca2+-dependent and Ca2+-independent protein kinase C changes in the brain of patients with Alzheimer's disease

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Constitutive and protein kinase C-regulated secretory cleavage of Alzheimer's beta-amyloid precursor protein: different control of early and late events by the proteasome.

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Secretory processing of the Alzheimer amyloid beta/A4 protein precursor is increased by protein phosphorylation

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Increased activity-regulating and neuroprotective efficacy of alpha-secretase-derived secreted amyloid precursor protein conferred by a C-terminal heparin-binding domain

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Biomedicine. Tauists and beta-aptists united--well almost!

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Utilization of the indirect lysosome targeting pathway by lysosome-associated membrane proteins (LAMPs) is influenced largely by the C-terminal residue of their GYXXphi targeting signals.

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The amyloid hypothesis of Alzheimer's disease: progress and problems on the road to therapeutics

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LR11/SorLA expression is reduced in sporadic Alzheimer disease but not in familial Alzheimer disease

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The production of post-Golgi vesicles requires a protein kinase C-like molecule, but not its phosphorylating activity

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12 December 2020

APP processing is regulated by cytoplasmic phosphorylation

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ADAMs family members as amyloid precursor protein alpha-secretases

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Identification of a novel conserved sorting motif required for retromer-mediated endosome-to-TGN retrieval

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PAT1, a microtubule-interacting protein, recognizes the basolateral sorting signal of amyloid precursor protein

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Sorting through the cell biology of Alzheimer's disease: intracellular pathways to pathogenesis

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The neuronal sortilin-related receptor SORL1 is genetically associated with Alzheimer disease

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Tyrosine 687 phosphorylated Alzheimer's amyloid precursor protein is retained intracellularly and exhibits a decreased turnover rate.

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Rab5-stimulated up-regulation of the endocytic pathway increases intracellular beta-cleaved amyloid precursor protein carboxyl-terminal fragment levels and Abeta production

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Protein phosphorylation inhibits production of Alzheimer amyloid beta/A4 peptide

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Current theories for the molecular and cellular pathogenesis of Alzheimer's disease

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SMAP2, a novel ARF GTPase-activating protein, interacts with clathrin and clathrin assembly protein and functions on the AP-1-positive early endosome/trans-Golgi network

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Signal-dependent trafficking of beta-amyloid precursor protein-transferrin receptor chimeras in madin-darby canine kidney cells

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Trafficking of cell-surface amyloid beta-protein precursor. II. Endocytosis, recycling and lysosomal targeting detected by immunolocalization

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Inhibition of protein phosphatase 1 stimulates secretion of Alzheimer amyloid precursor protein.

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Enhanced generation of Alzheimer's amyloid-beta following chronic exposure to phorbol ester correlates with differential effects on alpha and epsilon isozymes of protein kinase C.

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The transmembrane domain of the Alzheimer's beta-secretase (BACE1) determines its late Golgi localization and access to beta -amyloid precursor protein (APP) substrate

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CSF amyloid-beta-peptides in Alzheimer's disease, dementia with Lewy bodies and Parkinson's disease dementia

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Regulated cleavage of Alzheimer beta-amyloid precursor protein in the absence of the cytoplasmic tail

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Characterization of sorting signals in the beta-amyloid precursor protein cytoplasmic domain

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Assembly, trafficking and function of gamma-secretase

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Physiological regulation of the beta-amyloid precursor protein signaling domain by c-Jun N-terminal kinase JNK3 during neuronal differentiation.

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A model system to study intracellular trafficking and processing of the Alzheimer's amyloid precursor protein.

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Amyloid beta-peptide is produced by cultured cells during normal metabolism

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Retromer deficiency observed in Alzheimer's disease causes hippocampal dysfunction, neurodegeneration, and Abeta accumulation

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12 December 2020

Protein phosphorylation regulates secretion of Alzheimer beta/A4 amyloid precursor protein

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12 December 2020

Ectodomain phosphorylation of beta-amyloid precursor protein at two distinct cellular locations

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12 December 2020

Isolation and quantification of soluble Alzheimer's beta-peptide from biological fluids

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12 December 2020

The amyloid-beta precursor protein is phosphorylated via distinct pathways during differentiation, mitosis, stress, and degeneration

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12 December 2020

Intracellular sAPP retention in response to Abeta is mapped to cytoskeleton-associated structures

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12 December 2020

Hyperphosphorylation induces self-assembly of tau into tangles of paired helical filaments/straight filaments

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12 December 2020

The cytoplasmic domain of Alzheimer's amyloid precursor protein is phosphorylated at Thr654, Ser655, and Thr668 in adult rat brain and cultured cells.

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12 December 2020

Polarized transport of Alzheimer amyloid precursor protein is mediated by adaptor protein complex AP1-1B.

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12 December 2020

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Tyr687 dependent APP endocytosis and Abeta production.

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[alpha]-Secretase ADAM10 as well as [alpha]APPs is reduced in platelets and CSF of Alzheimer disease patients

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12 December 2020

Proteolytic processing of amyloid-beta precursor protein by secretases does not require cell surface transport

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12 December 2020

Regulated formation of Golgi secretory vesicles containing Alzheimer beta-amyloid precursor protein.

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12 December 2020

Neuronal LR11/sorLA expression is reduced in mild cognitive impairment

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12 December 2020

AP-1 and retromer play opposite roles in the trafficking of sortilin between the Golgi apparatus and the lysosomes

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12 December 2020

Active gamma-secretase complexes contain only one of each component

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12 December 2020

Phosphorylation of the cytoplasmic domain of Alzheimer's beta-amyloid precursor protein at Ser655 by a novel protein kinase.

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12 December 2020

Signal transduction therapeutics: relevance for Alzheimer's disease

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12 December 2020

Different temperature sensitivity of endosomes involved in transport to lysosomes and transcytosis in rat hepatocytes: analysis by free-flow electrophoresis

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12 December 2020

Trafficking of cell-surface amyloid beta-protein precursor. I. Secretion, endocytosis and recycling as detected by labeled monoclonal antibody

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Hyperphosphorylation and accumulation of neurofilament proteins in Alzheimer disease brain and in okadaic acid-treated SY5Y cells

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12 December 2020

Isoform specific amyloid-beta protein precursor metabolism.

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12 December 2020

Phosphorylation of Alzheimer amyloid precursor protein by protein kinase C.

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12 December 2020

10.1007/S11010-009-0084-7

Identifiers

DOI

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19 December 2017

PubMed ID

19381782

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19 December 2017