Physiological regulation of the beta-amyloid precursor protein signaling domain by c-Jun N-terminal kinase JNK3 during neuronal differentiation. (Q46535530)

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scientific article published in June 2005

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English	Physiological regulation of the beta-amyloid precursor protein signaling domain by c-Jun N-terminal kinase JNK3 during neuronal differentiation.	scientific article published in June 2005

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scholarly article

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Europe PubMed Central

22 December 2017

http://europepmc.org/abstract/MED/15944381

Physiological regulation of the beta-amyloid precursor protein signaling domain by c-Jun N-terminal kinase JNK3 during neuronal differentiation (English)

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12 May 2020

Dennis J. Selkoe

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Dennis J Selkoe

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12 May 2020

Richard Flavell

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Richard A Flavell

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12 May 2020

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W Taylor Kimberly

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12 May 2020

Jessica B Zheng

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12 May 2020

Terrence Town

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12 May 2020

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publication date

1 June 2005

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22 December 2017

http://europepmc.org/abstract/MED/15944381

Journal of Neuroscience

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12 May 2020

25

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12 May 2020

23

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12 May 2020

5533-5543

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Europe PubMed Central

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12 May 2020

Constitutive and regulated alpha-secretase cleavage of Alzheimer's amyloid precursor protein by a disintegrin metalloprotease

1 reference

https://pubmed.ncbi.nlm.nih.gov/15944381

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Age-related cognitive deficits, impaired long-term potentiation and reduction in synaptic marker density in mice lacking the beta-amyloid precursor protein

1 reference

https://pubmed.ncbi.nlm.nih.gov/15944381

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Notch signaling: cell fate control and signal integration in development

1 reference

https://pubmed.ncbi.nlm.nih.gov/15944381

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Role of phosphorylation of Alzheimer's amyloid precursor protein during neuronal differentiation.

1 reference

https://pubmed.ncbi.nlm.nih.gov/15944381

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The Drosophila beta-amyloid precursor protein homolog promotes synapse differentiation at the neuromuscular junction.

1 reference

https://pubmed.ncbi.nlm.nih.gov/15944381

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Beta-secretase cleavage of Alzheimer's amyloid precursor protein by the transmembrane aspartic protease BACE

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https://pubmed.ncbi.nlm.nih.gov/15944381

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Conversion of p35 to p25 deregulates Cdk5 activity and promotes neurodegeneration

1 reference

https://pubmed.ncbi.nlm.nih.gov/15944381

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

What the evolution of the amyloid protein precursor supergene family tells us about its function

1 reference

https://pubmed.ncbi.nlm.nih.gov/15944381

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Regulated intramembrane proteolysis: a control mechanism conserved from bacteria to humans

1 reference

https://pubmed.ncbi.nlm.nih.gov/15944381

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Transient structure of the amyloid precursor protein cytoplasmic tail indicates preordering of structure for binding to cytosolic factors

1 reference

https://pubmed.ncbi.nlm.nih.gov/15944381

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A monoclonal antibody to amyloid precursor protein induces neuronal apoptosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/15944381

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Neuron-specific phosphorylation of Alzheimer's beta-amyloid precursor protein by cyclin-dependent kinase 5.

1 reference

https://pubmed.ncbi.nlm.nih.gov/15944381

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Dual roles for c-Jun N-terminal kinase in developmental and stress responses in cerebellar granule neurons.

1 reference

https://pubmed.ncbi.nlm.nih.gov/15944381

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Signal transduction by the JNK group of MAP kinases

1 reference

https://pubmed.ncbi.nlm.nih.gov/15944381

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Notch signaling: from the outside in

1 reference

https://pubmed.ncbi.nlm.nih.gov/15944381

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Antibody-regulated neurotoxic function of cell-surface beta-amyloid precursor protein

1 reference

https://pubmed.ncbi.nlm.nih.gov/15944381

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Functional gamma-secretase inhibitors reduce beta-amyloid peptide levels in brain

1 reference

https://pubmed.ncbi.nlm.nih.gov/15944381

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Phosphorylation of thr(668) in the cytoplasmic domain of the Alzheimer's disease amyloid precursor protein by stress-activated protein kinase 1b (Jun N-terminal kinase-3).

1 reference

https://pubmed.ncbi.nlm.nih.gov/15944381

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Amino-terminal modification and tyrosine phosphorylation of [corrected] carboxy-terminal fragments of the amyloid precursor protein in Alzheimer's disease and Down's syndrome brain

1 reference

https://pubmed.ncbi.nlm.nih.gov/15944381

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

BACE1 is the major beta-secretase for generation of Abeta peptides by neurons

1 reference

https://pubmed.ncbi.nlm.nih.gov/15944381

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Phosphorylation-induced structural changes in the amyloid precursor protein cytoplasmic tail detected by NMR.

1 reference

https://pubmed.ncbi.nlm.nih.gov/15944381

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A transcriptionally [correction of transcriptively] active complex of APP with Fe65 and histone acetyltransferase Tip60

1 reference

https://pubmed.ncbi.nlm.nih.gov/15944381

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Distinct intramembrane cleavage of the beta-amyloid precursor protein family resembling gamma-secretase-like cleavage of Notch

1 reference

https://pubmed.ncbi.nlm.nih.gov/15944381

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Phosphorylation-dependent regulation of the interaction of amyloid precursor protein with Fe65 affects the production of beta-amyloid

1 reference

https://pubmed.ncbi.nlm.nih.gov/15944381

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Presenilin-dependent gamma-secretase processing of beta-amyloid precursor protein at a site corresponding to the S3 cleavage of Notch

1 reference

https://pubmed.ncbi.nlm.nih.gov/15944381

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A portrait of Alzheimer secretases--new features and familiar faces

1 reference

https://pubmed.ncbi.nlm.nih.gov/15944381

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The intracellular domain of the beta-amyloid precursor protein is stabilized by Fe65 and translocates to the nucleus in a notch-like manner

1 reference

https://pubmed.ncbi.nlm.nih.gov/15944381

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The amyloid precursor protein (APP)-cytoplasmic fragment generated by gamma-secretase is rapidly degraded but distributes partially in a nuclear fraction of neurones in culture

1 reference

https://pubmed.ncbi.nlm.nih.gov/15944381

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The gamma -secretase-cleaved C-terminal fragment of amyloid precursor protein mediates signaling to the nucleus

1 reference

https://pubmed.ncbi.nlm.nih.gov/15944381

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Insulin-degrading enzyme rapidly removes the beta-amyloid precursor protein intracellular domain (AICD)

1 reference

https://pubmed.ncbi.nlm.nih.gov/15944381

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The gamma-secretase-generated intracellular domain of beta-amyloid precursor protein binds Numb and inhibits Notch signaling

1 reference

https://pubmed.ncbi.nlm.nih.gov/15944381

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A RIP tide in neuronal signal transduction

1 reference

https://pubmed.ncbi.nlm.nih.gov/15944381

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A single c-Jun N-terminal kinase isoform (JNK3-p54) is an effector in both neuronal differentiation and cell death

1 reference

https://pubmed.ncbi.nlm.nih.gov/15944381

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Insulin-degrading enzyme regulates the levels of insulin, amyloid beta-protein, and the beta-amyloid precursor protein intracellular domain in vivo

1 reference

https://pubmed.ncbi.nlm.nih.gov/15944381

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Notch and Presenilin: regulated intramembrane proteolysis links development and degeneration.

1 reference

https://pubmed.ncbi.nlm.nih.gov/15944381

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

gamma-Secretase cleavage and binding to FE65 regulate the nuclear translocation of the intracellular C-terminal domain (ICD) of the APP family of proteins

1 reference

https://pubmed.ncbi.nlm.nih.gov/15944381

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Amyloid beta-peptide is produced by cultured cells during normal metabolism

1 reference

https://pubmed.ncbi.nlm.nih.gov/15944381

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Release of Alzheimer amyloid precursor derivatives stimulated by activation of muscarinic acetylcholine receptors

1 reference

https://pubmed.ncbi.nlm.nih.gov/15944381

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

APP processing is regulated by cytoplasmic phosphorylation

1 reference

https://pubmed.ncbi.nlm.nih.gov/15944381

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identity and function of γ‐secretase

1 reference

https://pubmed.ncbi.nlm.nih.gov/15944381

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Dissection of amyloid-beta precursor protein-dependent transcriptional transactivation.

1 reference

https://pubmed.ncbi.nlm.nih.gov/15944381

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cortical dysplasia resembling human type 2 lissencephaly in mice lacking all three APP family members

1 reference

https://pubmed.ncbi.nlm.nih.gov/15944381

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The molecular pathology of Alzheimer's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/15944381

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Localization of Alzheimer beta A4 amyloid precursor protein at central and peripheral synaptic sites.

1 reference

https://pubmed.ncbi.nlm.nih.gov/15944381

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Processing of Alzheimer beta/A4 amyloid precursor protein: modulation by agents that regulate protein phosphorylation

1 reference

https://pubmed.ncbi.nlm.nih.gov/15944381

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Isolation of intracellular membranes by means of sodium carbonate treatment: application to endoplasmic reticulum

1 reference

https://pubmed.ncbi.nlm.nih.gov/15944381

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Aggregation of secreted amyloid beta-protein into sodium dodecyl sulfate-stable oligomers in cell culture

1 reference

https://pubmed.ncbi.nlm.nih.gov/15944381

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Synaptotrophic effects of human amyloid β protein precursors in the cortex of transgenic mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/15944381

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Evidence that production and release of amyloid beta-protein involves the endocytic pathway

1 reference

https://pubmed.ncbi.nlm.nih.gov/15944381

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Activation of protein kinase C inhibits cellular production of the amyloid beta-protein

1 reference

https://pubmed.ncbi.nlm.nih.gov/15944381

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Inhibition of beta-amyloid production by activation of protein kinase C.

1 reference

https://pubmed.ncbi.nlm.nih.gov/15944381

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The amyloid precursor protein is developmentally regulated and correlated with synaptogenesis

1 reference

https://pubmed.ncbi.nlm.nih.gov/15944381

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

APPL, the Drosophila member of the APP-family, exhibits differential trafficking and processing in CNS neurons.

1 reference

https://pubmed.ncbi.nlm.nih.gov/15944381

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mice lacking p35, a neuronal specific activator of Cdk5, display cortical lamination defects, seizures, and adult lethality

1 reference

https://pubmed.ncbi.nlm.nih.gov/15944381

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Amyloid precursor protein processing and A beta42 deposition in a transgenic mouse model of Alzheimer disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/15944381

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The cytoplasmic domain of Alzheimer's amyloid precursor protein is phosphorylated at Thr654, Ser655, and Thr668 in adult rat brain and cultured cells.

1 reference

https://pubmed.ncbi.nlm.nih.gov/15944381

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Solution conformations of a peptide containing the cytoplasmic domain sequence of the beta amyloid precursor protein

1 reference

https://pubmed.ncbi.nlm.nih.gov/15944381

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Absence of excitotoxicity-induced apoptosis in the hippocampus of mice lacking the Jnk3 gene

1 reference

https://pubmed.ncbi.nlm.nih.gov/15944381

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Evidence that levels of presenilins (PS1 and PS2) are coordinately regulated by competition for limiting cellular factors.

1 reference

https://pubmed.ncbi.nlm.nih.gov/15944381

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Evidence that tumor necrosis factor alpha converting enzyme is involved in regulated alpha-secretase cleavage of the Alzheimer amyloid protein precursor

1 reference

https://pubmed.ncbi.nlm.nih.gov/15944381

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Alzheimer amyloid protein precursor in the rat hippocampus: transport and processing through the perforant path

1 reference

https://pubmed.ncbi.nlm.nih.gov/15944381

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1523/JNEUROSCI.4883-04.2005

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6724978&resulttype=core&format=json

12 May 2020

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6724978&resulttype=core&format=json

12 May 2020

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6724978&resulttype=core&format=json

12 May 2020

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