Chapter 2. From microbial products to novel drugs that target a multitude of disease indications (Q46046775)

19 December 2017

title

Chapter 2. From microbial products to novel drugs that target a multitude of disease indications (English)

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19 December 2017

author name string

Flavia Marinelli

series ordinal

1

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19 December 2017

language of work or name

English

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publication date

1 January 2009

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19 December 2017

published in

Methods in Enzymology

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19 December 2017

volume

458

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19 December 2017

page(s)

29-58

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19 December 2017

Mevinolin: a highly potent competitive inhibitor of hydroxymethylglutaryl-coenzyme A reductase and a cholesterol-lowering agent

cites work

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2809%2904802-2

7 January 2021

Mitomycin resistance in mammalian cells expressing the bacterial mitomycin C resistance protein MCRA

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2809%2904802-2

7 January 2021

Antibiotic production improvement in the rare actinomycete Planobispora rosea by selection of mutants resistant to the aminoglycosides streptomycin and gentamycin and to rifamycin

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2809%2904802-2

7 January 2021

Bioactive microbial metabolites

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2809%2904802-2

7 January 2021

Cyanobacteria from benthic mats of Antarctic lakes as a source of new bioactivities

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2809%2904802-2

7 January 2021

Biological effects of cyclosporin A: A new antilymphocytic agent

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2809%2904802-2

7 January 2021

Novel tetrapeptide inhibitors of bacterial protein synthesis produced by a Streptomyces sp.

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2809%2904802-2

7 January 2021

Crystal and molecular structure of compactin, a new antifungal metabolite from Penicillium brevicompactum

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2809%2904802-2

7 January 2021

Intermediary metabolism and antibiotic synthesis

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2809%2904802-2

7 January 2021

A novel lantibiotic acting on bacterial cell wall synthesis produced by the uncommon actinomycete Planomonospora sp.

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2809%2904802-2

7 January 2021

Determining the structure and mode of action of microbisporicin, a potent lantibiotic active against multiresistant pathogens.

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2809%2904802-2

7 January 2021

Synergy and contingency as driving forces for the evolution of multiple secondary metabolite production by Streptomyces species

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2809%2904802-2

7 January 2021

Paclitaxel (Taxol): a success story with valuable lessons for natural product drug discovery and development

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2809%2904802-2

7 January 2021

The world of subinhibitory antibiotic concentrations

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2809%2904802-2

7 January 2021

Contributions of microorganisms to industrial biology

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2809%2904802-2

7 January 2021

Analysis of the cryptophycin P450 epoxidase reveals substrate tolerance and cooperativity

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2809%2904802-2

7 January 2021

The biosynthetic gene cluster for the antitumor drug bleomycin from Streptomyces verticillus ATCC15003 supporting functional interactions between nonribosomal peptide synthetases and a polyketide synthase

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2809%2904802-2

7 January 2021

Monacolin K, a new hypocholesterolemic agent that specifically inhibits 3-hydroxy-3-methylglutaryl coenzyme A reductase

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2809%2904802-2

7 January 2021

Competitive inhibition of 3-hydroxy-3-methylglutaryl coenzyme A reductase by ML-236A and ML-236B fungal metabolites, having hypocholesterolemic activity

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2809%2904802-2

7 January 2021

A simple screening method for insecticidal substances from actinomycetes.

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2809%2904802-2

7 January 2021

Antibiotics as signals that trigger specific bacterial responses

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2809%2904802-2

7 January 2021

Antitumor antibiotics: bleomycin, enediynes, and mitomycin

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2809%2904802-2

7 January 2021

In vivo manipulation of the bleomycin biosynthetic gene cluster in Streptomyces verticillus ATCC15003 revealing new insights into its biosynthetic pathway

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2809%2904802-2

7 January 2021

Myxobacteria isolated in Israel as potential source of new anti-infectives

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2809%2904802-2

7 January 2021

Epothilons A and B: antifungal and cytotoxic compounds from Sorangium cellulosum (Myxobacteria). Production, physico-chemical and biological properties

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2809%2904802-2

7 January 2021

Mutation and a high-throughput screening method for improving the production of Epothilones of Sorangium

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2809%2904802-2

7 January 2021

Lambda red-mediated genetic manipulation of antibiotic-producing Streptomyces.

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2809%2904802-2

7 January 2021

Structural mechanism for statin inhibition of HMG-CoA reductase

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2809%2904802-2

7 January 2021

Heterologous expression of epothilone biosynthetic genes in Myxococcus xanthus

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2809%2904802-2

7 January 2021

Modulation of Polyketide Synthase Activity by Accessory Proteins During Lovastatin Biosynthesis

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2809%2904802-2

7 January 2021

FK-506, a novel immunosuppressant isolated from a Streptomyces. I. Fermentation, isolation, and physico-chemical and biological characteristics

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2809%2904802-2

7 January 2021

New aspects of natural products in drug discovery

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2809%2904802-2

7 January 2021

Doxorubicin overproduction in Streptomyces peucetius: cloning and characterization of the dnrU ketoreductase and dnrV genes and the doxA cytochrome P-450 hydroxylase gene

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2809%2904802-2

7 January 2021

Production of the antitumor drug epirubicin (4'-epidoxorubicin) and its precursor by a genetically engineered strain of Streptomyces peucetius

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2809%2904802-2

7 January 2021

Biosynthetic characterization and chemoenzymatic assembly of the cryptophycins. Potent anticancer agents from cyanobionts

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2809%2904802-2

7 January 2021

Natural products as immunosuppressive agents

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2809%2904802-2

7 January 2021

Biosynthesis and biotechnological production of statins by filamentous fungi and application of these cholesterol-lowering drugs.

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2809%2904802-2

7 January 2021

Molecular characterization and analysis of the biosynthetic gene cluster for the antitumor antibiotic mitomycin C from Streptomyces lavendulae NRRL 2564

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2809%2904802-2

7 January 2021

The biosynthetic gene cluster for the microtubule-stabilizing agents epothilones A and B from Sorangium cellulosum So ce90

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2809%2904802-2

7 January 2021

Natural products as sources of new drugs over the last 25 years

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2809%2904802-2

7 January 2021

Cyclophilin binds to the region of cyclosporine involved in its immunosuppressive activity

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2809%2904802-2

7 January 2021

Isolation and purification of cyanobacteria

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2809%2904802-2

7 January 2021

Combinatorial biosynthesis of antitumor indolocarbazole compounds

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2809%2904802-2

7 January 2021

Construction and in vitro analysis of a new bi-modular polypeptide synthetase for synthesis of N-methylated acyl peptides

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2809%2904802-2

7 January 2021

Isolation, structure, and HIV-1-integrase inhibitory activity of structurally diverse fungal metabolites

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2809%2904802-2

7 January 2021

Inhibitors of type-I interleukin-1 receptor from microbial metabolites.

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2809%2904802-2

7 January 2021

Inhibitors of myo-inositol monophosphatase, ATCC 20928 factors A and C. Isolation, physico-chemical characterization and biological properties

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2809%2904802-2

7 January 2021

Taxol and taxane production by Taxomyces andreanae, an endophytic fungus of Pacific yew.

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2809%2904802-2

7 January 2021

Harnessing endophytes for industrial microbiology

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2809%2904802-2

7 January 2021

Generation of new epothilones by genetic engineering of a polyketide synthase in Myxococcus xanthus.

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2809%2904802-2

7 January 2021

Cloning and heterologous expression of the epothilone gene cluster.

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2809%2904802-2

7 January 2021

Rapamycin (AY-22,989), a new antifungal antibiotic. I. Taxonomy of the producing streptomycete and isolation of the active principle

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2809%2904802-2

7 January 2021

Functions of secondary metabolites

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2809%2904802-2

7 January 2021

Plant antitumor agents. VI. The isolation and structure of taxol, a novel antileukemic and antitumor agent from Taxus brevifolia

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2809%2904802-2

7 January 2021

A genomics-guided approach for discovering and expressing cryptic metabolic pathways.

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2809%2904802-2

7 January 2021

10.1016/S0076-6879(09)04802-2

Identifiers

DOI

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19 December 2017

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19 December 2017