Pancreas-specific Pten deficiency causes partial resistance to diabetes and elevated hepatic AKT signaling (Q46051852)

19 December 2017

title

Pancreas-specific Pten deficiency causes partial resistance to diabetes and elevated hepatic AKT signaling (English)

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19 December 2017

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Zan Tong

1

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19 December 2017

Yan Fan

2

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19 December 2017

Weiqi Zhang

3

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19 December 2017

Jun Xu

4

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19 December 2017

Jing Cheng

5

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19 December 2017

Mingxiao Ding

6

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19 December 2017

Hongkui Deng

7

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19 December 2017

publication date

1 June 2009

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19 December 2017

published in

Cell Research

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19 December 2017

volume

19

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19 December 2017

issue

6

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19 December 2017

page(s)

710-719

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19 December 2017

https://scigraph.springernature.com/pub.10.1038/cr.2009.42

exact match

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cites work

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Specific inhibition of PTEN expression reverses hyperglycemia in diabetic mice

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The tumor suppressor, PTEN/MMAC1, dephosphorylates the lipid second messenger, phosphatidylinositol 3,4,5-trisphosphate

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Insulin resistance and a diabetes mellitus-like syndrome in mice lacking the protein kinase Akt2 (PKB beta)

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Deletion of Pten in mouse brain causes seizures, ataxia and defects in soma size resembling Lhermitte-Duclos disease

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T Cell-Specific Loss of Pten Leads to Defects in Central and Peripheral Tolerance

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Critical roles of Pten in B cell homeostasis and immunoglobulin class switch recombination.

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Early onset of neoplasia in the prostate and skin of mice with tissue-specific deletion of Pten

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Liver-specific deletion of negative regulator Pten results in fatty liver and insulin hypersensitivity [corrected]

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Insulin hypersensitivity and resistance to streptozotocin-induced diabetes in mice lacking PTEN in adipose tissue

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Muscle-specific Pten deletion protects against insulin resistance and diabetes

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Pten constrains centroacinar cell expansion and malignant transformation in the pancreas

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Essential role of Pten in body size determination and pancreatic beta-cell homeostasis in vivo

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Selective deletion of Pten in pancreatic beta cells leads to increased islet mass and resistance to STZ-induced diabetes

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c-Jun promotes cellular survival by suppression of PTEN.

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An Hsp70-like protein in the ER: identity with the 78 kd glucose-regulated protein and immunoglobulin heavy chain binding protein

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Direct eIF2-eIF3 contact in the multifactor complex is important for translation initiation in vivo

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21 January 2018

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7 January 2021

Banting Lecture. Insulin action, diabetogenes, and the cause of type II diabetes

1 reference

https://api.crossref.org/works/10.1038%2FCR.2009.42

7 January 2021

Living with lethal PIP3 levels: viability of flies lacking PTEN restored by a PH domain mutation in Akt/PKB.

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7 January 2021

Hepatocyte-specific Pten deficiency results in steatohepatitis and hepatocellular carcinomas

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7 January 2021

Pancreatic elastase-1 in stools, a marker of exocrine pancreas function, correlates with both residual beta-cell secretion and metabolic control in type 1 diabetic subjects

1 reference

https://api.crossref.org/works/10.1038%2FCR.2009.42

7 January 2021

Calcium-sensitive transcriptional activation of the proximal CCAAT regulatory element of the grp78/BiP promoter by the human nuclear factor CBF/NF-Y.

1 reference

https://api.crossref.org/works/10.1038%2FCR.2009.42

7 January 2021

Identifiers

DOI

10.1038/CR.2009.42

1 reference

19 December 2017

PubMed ID

19365404

1 reference

19 December 2017