Disposition and toxicity of trabectedin (ET-743) in wild-type and mdr1 gene (P-gp) knock-out mice. (Q46111736)

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22 January 2020

title

Disposition and toxicity of trabectedin (ET-743) in wild-type and mdr1 gene (P-gp) knock-out mice (English)

1 reference

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22 January 2020

4

1 reference

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22 January 2020

Jan H Beumer

1

1 reference

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22 January 2020

Luis López Lázaro

6

1 reference

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22 January 2020

8

J H Beijnen

1 reference

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22 January 2020

author name string

N E Franke

2

1 reference

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22 January 2020

R Tolboom

3

1 reference

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22 January 2020

H Rosing

5

1 reference

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22 January 2020

J H M Schellens

7

1 reference

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22 January 2020

O van Tellingen

9

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22 January 2020

publication date

24 February 2009

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Investigational New Drugs

22 January 2020

published in

1 reference

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22 January 2020

volume

28

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22 January 2020

issue

2

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22 January 2020

page(s)

145-155

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Expression and localization of P-glycoprotein in human heart: effects of cardiomyopathy.

22 January 2020

cites work

1 reference

Crossref

https://api.crossref.org/works/10.1007%2FS10637-009-9234-8

Hepatotoxicity and metabolism of trabectedin: a literature review.

21 January 2018

1 reference

Crossref

https://api.crossref.org/works/10.1007%2FS10637-009-9234-8

Increased accumulation of doxorubicin and doxorubicinol in cardiac tissue of mice lacking mdr1a P-glycoprotein

21 January 2018

1 reference

12 December 2020

Hepatobiliary and intestinal clearance of amphiphilic cationic drugs in mice in which both mdr1a and mdr1b genes have been disrupted

1 reference

12 December 2020

Gender-based differences in pharmacokinetics in laboratory animal models

1 reference

12 December 2020

Modulation of trabectedin (ET-743) hepatobiliary disposition by multidrug resistance-associated proteins (Mrps) may prevent hepatotoxicity

1 reference

12 December 2020

The importance of drug-transporting P-glycoproteins in toxicology

1 reference

12 December 2020

Quantitative determination of Ecteinascidin 743 in human plasma by miniaturized high-performance liquid chromatography coupled with electrospray ionization tandem mass spectrometry

1 reference

12 December 2020

Phase I and pharmacokinetic study of Yondelis (Ecteinascidin-743; ET-743) administered as an infusion over 1 h or 3 h every 21 days in patients with solid tumours

1 reference

12 December 2020

Ecteinascidin 743, a transcription-targeted chemotherapeutic that inhibits MDR1 activation

1 reference

12 December 2020

Rat and human liver cytochrome P-450 isoform metabolism of ecteinascidin 743 does not predict gender-dependent toxicity in humans

1 reference

12 December 2020

The role of mdr1a P-glycoprotein in the biliary and intestinal secretion of doxorubicin and vinblastine in mice

1 reference

12 December 2020

A phase II study of ET-743/trabectedin ('Yondelis') for patients with advanced gastrointestinal stromal tumours

1 reference

12 December 2020

Hepatobiliary damage and changes in hepatic gene expression caused by the antitumor drug ecteinascidin-743 (ET-743) in the female rat

1 reference

12 December 2020

Role of P-glycoprotein in pharmacokinetics: clinical implications

1 reference

12 December 2020

Preclinical and clinical results with the natural marine product ET-743

1 reference

12 December 2020

Trabectedin : a review of its use in the management of soft tissue sarcoma and ovarian cancer.

1 reference

12 December 2020

Sex-specific cytochrome P450 as a cause of sex- and species-related differences in drug toxicity

1 reference

12 December 2020

Trabectedin (ET-743, Yondelis) is a substrate for P-glycoprotein, but only high expression of P-glycoprotein confers the multidrug resistance phenotype

1 reference

12 December 2020

Metabolism of trabectedin (ET-743, Yondelis) in patients with advanced cancer

1 reference

12 December 2020

The orphan nuclear receptor SXR coordinately regulates drug metabolism and efflux

1 reference

12 December 2020

Limited oral bioavailability and active epithelial excretion of paclitaxel (Taxol) caused by P-glycoprotein in the intestine

1 reference

12 December 2020

Yondelis (trabectedin, ET-743): the development of an anticancer agent of marine origin

1 reference

12 December 2020

DNA sequence- and structure-selective alkylation of guanine N2 in the DNA minor groove by ecteinascidin 743, a potent antitumor compound from the Caribbean tunicate Ecteinascidia turbinata

1 reference

12 December 2020

Altered expression of hepatic cytochromes P-450 in mice deficient in one or more mdr1 genes.

1 reference

12 December 2020

Phase I and pharmacokinetic study of ecteinascidin-743, a new marine compound, administered as a 24-hour continuous infusion in patients with solid tumors.

1 reference

12 December 2020

Overcoming multidrug drug resistance in P-glycoprotein/MDR1-overexpressing cell lines by ecteinascidin 743.

1 reference

12 December 2020

Interference of transcriptional activation by the antineoplastic drug ecteinascidin-743.

1 reference

12 December 2020

Search for metabolites of ecteinascidin 743, a novel, marine-derived, anti-cancer agent, in man.

1 reference

12 December 2020

Pharmacokinetics and pharmacodynamics of the novel marine-derived anticancer agent ecteinascidin 743 in a phase I dose-finding study.

1 reference

12 December 2020

P-Glycoprotein, a gatekeeper in the blood-brain barrier

1 reference

12 December 2020

Contribution of the murine mdr1a P-glycoprotein to hepatobiliary and intestinal elimination of cationic drugs as measured in mice with an mdr1a gene disruption.

1 reference

12 December 2020

Phase II study of ecteinascidin 743 in heavily pretreated patients with recurrent osteosarcoma

1 reference

12 December 2020

Absence of the mdr1a P-Glycoprotein in mice affects tissue distribution and pharmacokinetics of dexamethasone, digoxin, and cyclosporin A.

1 reference

12 December 2020

Phase II and pharmacokinetic study of ecteinascidin 743 in patients with progressive sarcomas of soft tissues refractory to chemotherapy.

1 reference

12 December 2020

Normal viability and altered pharmacokinetics in mice lacking mdr1-type (drug-transporting) P-glycoproteins

1 reference

12 December 2020

Antiproliferative activity of ecteinascidin 743 is dependent upon transcription-coupled nucleotide-excision repair.

1 reference

12 December 2020

Trabectedin (Yondelis, formerly ET-743), a mass balance study in patients with advanced cancer.

1 reference

12 December 2020