Relative importance of intestinal and hepatic glucuronidation-impact on the prediction of drug clearance (Q46137927)

19 December 2017

title

Relative importance of intestinal and hepatic glucuronidation-impact on the prediction of drug clearance (English)

1 reference

19 December 2017

author

Aleksandra Galetin

series ordinal

3

1 reference

19 December 2017

author name string

Helen E Cubitt

series ordinal

1

1 reference

19 December 2017

J Brian Houston

series ordinal

2

1 reference

19 December 2017

publication date

31 January 2009

1 reference

19 December 2017

published in

Pharmaceutical Research

1 reference

19 December 2017

volume

26

1 reference

19 December 2017

issue

5

1 reference

19 December 2017

page(s)

1073-1083

1 reference

19 December 2017

Pharmacokinetics and bioavailability of mycophenolate mofetil in healthy subjects after single-dose oral and intravenous administration

cites work

1 reference

Crossref

https://api.crossref.org/works/10.1007%2FS11095-008-9823-9

Pharmacokinetics of intravenous and oral salbutamol and its sulphate conjugate

21 January 2018

1 reference

Crossref

https://api.crossref.org/works/10.1007%2FS11095-008-9823-9

Genetic multiplicity of the human UDP-glucuronosyltransferases and regulation in the gastrointestinal tract

21 January 2018

1 reference

12 December 2020

A unified model for predicting human hepatic, metabolic clearance from in vitro intrinsic clearance data in hepatocytes and microsomes

1 reference

12 December 2020

Characterization of raloxifene glucuronidation in vitro: contribution of intestinal metabolism to presystemic clearance

1 reference

12 December 2020

The human intestinal cytochrome P450 "pie".

1 reference

12 December 2020

In vitro-in vivo correlations for drugs eliminated by glucuronidation: investigations with the model substrate zidovudine

1 reference

12 December 2020

In vitro analysis of human drug glucuronidation and prediction of in vivo metabolic clearance

1 reference

12 December 2020

In vitro glucuronidation using human liver microsomes and the pore-forming peptide alamethicin.

1 reference

12 December 2020

Pharmacokinetics of intravenous salbutamol in renal insufficiency and its biological effects.

1 reference

12 December 2020

Microsomal prediction ofin vivoclearance and associated interindividual variability of six benzodiazepines in humans

1 reference

12 December 2020

Species- and disposition model-dependent metabolism of raloxifene in gut and liver: role of UGT1A10.

1 reference

12 December 2020

Why is it challenging to predict intestinal drug absorption and oral bioavailability in human using rat model.

1 reference

12 December 2020

Prediction of in vivo drug-drug interactions from in vitro data: impact of incorporating parallel pathways of drug elimination and inhibitor absorption rate constant

1 reference

12 December 2020

The "albumin effect" and drug glucuronidation: bovine serum albumin and fatty acid-free human serum albumin enhance the glucuronidation of UDP-glucuronosyltransferase (UGT) 1A9 substrates but not UGT1A1 and UGT1A6 activities.

1 reference

12 December 2020

Drug-drug interactions for UDP-glucuronosyltransferase substrates: a pharmacokinetic explanation for typically observed low exposure (AUCi/AUC) ratios

1 reference

12 December 2020

N-glucuronidation of carbamazepine in human tissues is mediated by UGT2B7.

1 reference

12 December 2020

Interaction of human serum albumin with the electrophilic metabolite 1-O-gemfibrozil-beta-D-glucuronide.

1 reference

12 December 2020

Pharmacokinetics and absolute bioavailability of salbutamol in healthy adult volunteers

1 reference

12 December 2020

Substrate depletion approach for determining in vitro metabolic clearance: time dependencies in hepatocyte and microsomal incubations

1 reference

12 December 2020

Altered AZT (3'-azido-3'-deoxythymidine) glucuronidation kinetics in liver microsomes as an explanation for underprediction of in vivo clearance: comparison to hepatocytes and effect of incubation environment

1 reference

12 December 2020

Drug lipophilicity and microsomal protein concentration as determinants in the prediction of the fraction unbound in microsomal incubations.

1 reference

12 December 2020

The glucuronidation of mycophenolic acid by human liver, kidney and jejunum microsomes

1 reference

12 December 2020

Application of CYP3A4 in vitro data to predict clinical drug-drug interactions; predictions of compounds as objects of interaction

1 reference

12 December 2020

The role of hepatic and extrahepatic UDP-glucuronosyltransferases in human drug metabolism

1 reference

12 December 2020

Prediction of human clearance of twenty-nine drugs from hepatic microsomal intrinsic clearance data: An examination of in vitro half-life approach and nonspecific binding to microsomes.

1 reference

12 December 2020

Quercetin pharmacokinetics in humans

1 reference

12 December 2020

Disposition mechanisms of raloxifene in the human intestinal Caco-2 model

1 reference

12 December 2020

Acyl glucuronides revisited: is the glucuronidation process a toxification as well as a detoxification mechanism?

1 reference

12 December 2020

Binding of drugs to hepatic microsomes: comment and assessment of current prediction methodology with recommendation for improvement

1 reference

12 December 2020

Utility of Hepatocytes in Predicting Drug Metabolism: Comparison of Hepatic Intrinsic Clearance in Rats and Humans in Vivo and in Vitro

1 reference

12 December 2020

Prediction of human drug clearance from in vitro and preclinical data using physiologically based and empirical approaches

1 reference

12 December 2020

Intestinal UGTs as potential modifiers of pharmacokinetics and biological responses to drugs and xenobiotics

1 reference

12 December 2020

UDP-glucuronosyltransferases and clinical drug-drug interactions

1 reference

12 December 2020

Utility of in vitro drug metabolism data in predicting in vivo metabolic clearance

1 reference

12 December 2020

An investigation of human and rat liver microsomal mycophenolic acid glucuronidation: evidence for a principal role of UGT1A enzymes and species differences in UGT1A specificity

1 reference

12 December 2020

Prediction of drug clearance by glucuronidation from in vitro data: use of combined cytochrome P450 and UDP-glucuronosyltransferase cofactors in alamethicin-activated human liver microsomes

1 reference

12 December 2020

Troglitazone glucuronidation in human liver and intestine microsomes: high catalytic activity of UGT1A8 and UGT1A10.

1 reference

12 December 2020

Intestinal and Hepatic Metabolic Activity of Five Cytochrome P450 Enzymes: Impact on Prediction of First-Pass Metabolism

1 reference

12 December 2020

The UDP-glucuronosyltransferase 2B7 isozyme is responsible for gemfibrozil glucuronidation in the human liver.

1 reference

12 December 2020

The effect of incubation conditions on the enzyme kinetics of udp-glucuronosyltransferases

1 reference

12 December 2020

Evaluation of cryopreserved human hepatocytes as an alternative in vitro system to microsomes for the prediction of metabolic clearance.

1 reference

12 December 2020

Use of in vitro and in vivo data to estimate the likelihood of metabolic pharmacokinetic interactions

1 reference

12 December 2020

Characterization of interintestinal and intraintestinal variations in human CYP3A-dependent metabolism.

1 reference

12 December 2020

Binding of inhibitory fatty acids is responsible for the enhancement of UDP-glucuronosyltransferase 2B7 activity by albumin: implications for in vitro-in vivo extrapolation

1 reference

12 December 2020

In vitro-in vivo correlation for drugs and other compounds eliminated by glucuronidation in humans: pitfalls and promises

1 reference

12 December 2020

Quantitative regioselectivity of glucuronidation of quercetin by recombinant UDP-glucuronosyltransferases 1A9 and 1A3 using enzymatic kinetic parameters

1 reference

12 December 2020

The pharmacokinetics of diclofenac sodium following intravenous and oral administration

1 reference

12 December 2020

Is the role of the small intestine in first-pass metabolism overemphasized?

1 reference

12 December 2020

Pharmacokinetics of raloxifene and its clinical application

1 reference

12 December 2020

Scaling factors for the extrapolation of in vivo metabolic drug clearance from in vitro data: reaching a consensus on values of human microsomal protein and hepatocellularity per gram of liver.

1 reference

12 December 2020

Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds

1 reference

12 December 2020

Simulation and prediction of in vivo drug metabolism in human populations from in vitro data

1 reference

12 December 2020

The main role of UGT1A9 in the hepatic metabolism of mycophenolic acid and the effects of naturally occurring variants

1 reference

12 December 2020

Glucuronidation in vitro and in vivo. Comparison of intestinal and hepatic conjugation of morphine, naloxone, and buprenorphine

1 reference

12 December 2020

10.1007/S11095-008-9823-9

Identifiers

DOI

1 reference

19 December 2017

1 reference

19 December 2017