Chronic GluN2B antagonism disrupts behavior in wild-type mice without protecting against synapse loss or memory impairment in Alzheimer's disease mouse models. (Q46184244)

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English	Chronic GluN2B antagonism disrupts behavior in wild-type mice without protecting against synapse loss or memory impairment in Alzheimer's disease mouse models.	scientific article

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20 March 2020

Chronic GluN2B antagonism disrupts behavior in wild-type mice without protecting against synapse loss or memory impairment in Alzheimer's disease mouse models (English)

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20 March 2020

Alzheimer's disease

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Jesse E Hanson

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20 March 2020

William J Meilandt

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20 March 2020

Alvin Gogineni

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20 March 2020

Paul Reynen

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20 March 2020

James Herrington

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Robby M Weimer

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Kimberly Scearce-Levie

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20 March 2020

Qiang Zhou

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1 June 2014

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20 March 2020

Journal of Neuroscience

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20 March 2020

34

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20 March 2020

8277-8288

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20 March 2020

Imaging neuronal subsets in transgenic mice expressing multiple spectral variants of GFP

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Increased sensitivity to N-methyl-D-aspartate receptor-mediated excitotoxicity in a mouse model of Huntington's disease

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Extrasynaptic NMDARs oppose synaptic NMDARs by triggering CREB shut-off and cell death pathways

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Imaging Abeta plaques in living transgenic mice with multiphoton microscopy and methoxy-X04, a systemically administered Congo red derivative

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PS2APP transgenic mice, coexpressing hPS2mut and hAPPswe, show age-related cognitive deficits associated with discrete brain amyloid deposition and inflammation.

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Fibrillar amyloid deposition leads to local synaptic abnormalities and breakage of neuronal branches.

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Modulation of triheteromeric NMDA receptors by N-terminal domain ligands

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12 December 2020

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Acute gamma-secretase inhibition improves contextual fear conditioning in the Tg2576 mouse model of Alzheimer's disease.

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The effect of the selective NMDA receptor antagonist traxoprodil in the treatment of traumatic brain injury

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Early-onset behavioral and synaptic deficits in a mouse model of Alzheimer's disease

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Neural cell adhesion molecule-associated polysialic acid inhibits NR2B-containing N-methyl-D-aspartate receptors and prevents glutamate-induced cell death

1 reference

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Acquisition of fear extinction requires activation of NR2B-containing NMDA receptors in the lateral amygdala.

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12 December 2020

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NMDA receptor subunits have differential roles in mediating excitotoxic neuronal death both in vitro and in vivo

1 reference

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12 December 2020

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Extrasynaptic and synaptic NMDA receptors form stable and uniform pools in rat hippocampal slices.

1 reference

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12 December 2020

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Physical basis of cognitive alterations in alzheimer's disease: Synapse loss is the major correlate of cognitive impairment

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Effects of a NR2B selective NMDA glutamate antagonist, CP-101,606, on dyskinesia and Parkinsonism.

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Fear memory impairing effects of systemic treatment with the NMDA NR2B subunit antagonist, Ro 25-6981, in mice: attenuation with ageing

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12 December 2020

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An innovative design to establish proof of concept of the antidepressant effects of the NR2B subunit selective N-methyl-D-aspartate antagonist, CP-101,606, in patients with treatment-refractory major depressive disorder.

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Expression of transgenic APP mRNA is the key determinant for beta-amyloid deposition in PS2APP transgenic mice.

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12 December 2020

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Contribution of hippocampal and extra-hippocampal NR2B-containing NMDA receptors to performance on spatial learning tasks

1 reference

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12 December 2020

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In vivo evidence for NMDA receptor-mediated excitotoxicity in a murine genetic model of Huntington disease.

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12 December 2020

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Single-dose administration of MK-0657, an NR2B-selective NMDA antagonist, does not result in clinically meaningful improvement in motor function in patients with moderate Parkinson's disease.

1 reference

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12 December 2020

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GluN2B subunit-containing NMDA receptor antagonists prevent Abeta-mediated synaptic plasticity disruption in vivo.

1 reference

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12 December 2020

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Early neuronal dysfunction by amyloid β oligomers depends on activation of NR2B-containing NMDA receptors

1 reference

https://pubmed.ncbi.nlm.nih.gov/24920631

12 December 2020

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DAPK1 interaction with NMDA receptor NR2B subunits mediates brain damage in stroke

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12 December 2020

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Early increase in extrasynaptic NMDA receptor signaling and expression contributes to phenotype onset in Huntington's disease mice

1 reference

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12 December 2020

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Imbalanced pattern completion vs. separation in cognitive disease: network simulations of synaptic pathologies predict a personalized therapeutics strategy

1 reference

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12 December 2020

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Synaptic versus extrasynaptic NMDA receptor signalling: implications for neurodegenerative disorders

1 reference

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12 December 2020

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Triheteromeric NR1/NR2A/NR2B receptors constitute the major N-methyl-D-aspartate receptor population in adult hippocampal synapses

1 reference

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12 December 2020

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Therapeutic significance of NR2B-containing NMDA receptors and mGluR5 metabotropic glutamate receptors in mediating the synaptotoxic effects of β-amyloid oligomers on long-term potentiation (LTP) in murine hippocampal slices.

1 reference

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Stroke intervention pathways: NMDA receptors and beyond

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Blockade of NMDA GluN2B receptors selectively impairs behavioral flexibility but not initial discrimination learning.

1 reference

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12 December 2020

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12 December 2020

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Soluble Aβ oligomers inhibit long-term potentiation through a mechanism involving excessive activation of extrasynaptic NR2B-containing NMDA receptors

1 reference

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12 December 2020

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Distinct modes of AMPA receptor suppression at developing synapses by GluN2A and GluN2B: single-cell NMDA receptor subunit deletion in vivo.

1 reference

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12 December 2020

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Synaptic changes in Alzheimer's disease and its models

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12 December 2020

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Endoplasmic reticulum stress occurs downstream of GluN2B subunit of N-methyl-d-aspartate receptor in mature hippocampal cultures treated with amyloid-β oligomers

1 reference

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12 December 2020

based on heuristic

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A Randomized, placebo-controlled, crossover pilot trial of the oral selective NR2B antagonist MK-0657 in patients with treatment-resistant major depressive disorder

1 reference

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12 December 2020

based on heuristic

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NR2B-dependent plasticity of adult-born granule cells is necessary for context discrimination

1 reference

https://pubmed.ncbi.nlm.nih.gov/24920631

12 December 2020

based on heuristic

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Synaptic and extrasynaptic NMDA receptors are gated by different endogenous coagonists

1 reference

https://pubmed.ncbi.nlm.nih.gov/24920631

12 December 2020

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GluN2B antagonism affects interneurons and leads to immediate and persistent changes in synaptic plasticity, oscillations, and behavior

1 reference

https://pubmed.ncbi.nlm.nih.gov/24920631

12 December 2020

based on heuristic

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NMDA receptors subserve persistent neuronal firing during working memory in dorsolateral prefrontal cortex

1 reference

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12 December 2020

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Active avoidance learning requires prefrontal suppression of amygdala-mediated defensive reactions

1 reference

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12 December 2020

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A neural circuit for memory specificity and generalization

1 reference

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12 December 2020

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NMDA receptors in nervous system diseases.

1 reference

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

NMDA receptor subunit diversity: impact on receptor properties, synaptic plasticity and disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/24920631

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Triheteromeric NMDA receptors at hippocampal synapses

1 reference

https://pubmed.ncbi.nlm.nih.gov/24920631

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A prominent role for triheteromeric GluN1/GluN2A/GluN2B NMDARs at central synapses

1 reference

https://pubmed.ncbi.nlm.nih.gov/24920631

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Distinct functional and pharmacological properties of Triheteromeric GluN1/GluN2A/GluN2B NMDA receptors.

1 reference

https://pubmed.ncbi.nlm.nih.gov/24920631

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Dynamics of the CA3 pyramidal neuron autoassociative memory network in the hippocampus.

1 reference

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inferred from PubMed ID database lookup

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1 reference

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12 December 2020

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Ro 25-6981, a highly potent and selective blocker of N-methyl-D-aspartate receptors containing the NR2B subunit. Characterization in vitro

1 reference

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1 reference

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Identifiers

10.1523/JNEUROSCI.5106-13.2014

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20 March 2020

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20 March 2020

PubMed publication ID

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24920631%20AND%20SRC:MED&resulttype=core&format=json

20 March 2020

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