FGF23 Regulates Bone Mineralization in a 1,25(OH)2 D3 and Klotho-Independent Manner (Q46280374)

21 December 2017

title

FGF23 Regulates Bone Mineralization in a 1,25(OH)2 D3 and Klotho-Independent Manner (English)

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4

Klaus Klaushofer

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author name string

Sathish Kumar Murali

1

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Paul Roschger

2

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Ute Zeitz

3

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Olena Andrukhova

5

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Reinhold G Erben

6

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publication date

1 August 2015

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Journal of Bone and Mineral Research

published in

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volume

31

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page(s)

129-142

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issue

1

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Circulating FGF-23 is regulated by 1alpha,25-dihydroxyvitamin D3 and phosphorus in vivo

cites work

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FGF23 acts directly on renal proximal tubules to induce phosphaturia through activation of the ERK1/2-SGK1 signaling pathway

21 January 2018

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FGF-23 is a potent regulator of vitamin D metabolism and phosphate homeostasis

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Mutation of the mouse klotho gene leads to a syndrome resembling ageing

21 January 2018

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Increased osteopontin contributes to inhibition of bone mineralization in FGF23-deficient mice

21 January 2018

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Klotho converts canonical FGF receptor into a specific receptor for FGF23

21 January 2018

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Klotho lacks a vitamin D independent physiological role in glucose homeostasis, bone turnover, and steady-state PTH secretion in vivo

21 January 2018

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Homozygous ablation of fibroblast growth factor-23 results in hyperphosphatemia and impaired skeletogenesis, and reverses hypophosphatemia in Phex-deficient mice

21 January 2018

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Ablation of vitamin D signaling rescues bone, mineral, and glucose homeostasis in Fgf-23 deficient mice.

21 January 2018

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Deletion of PTH rescues skeletal abnormalities and high osteopontin levels in Klotho-/- mice

21 January 2018

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Normocalcemia is maintained in mice under conditions of calcium malabsorption by vitamin D-induced inhibition of bone mineralization.

21 January 2018

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Inorganic pyrophosphate in plasma in normal persons and in patients with hypophosphatasia, osteogenesis imperfecta, and other disorders of bone

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Mineral formation in joints caused by complete or joint-specific loss of ANK function.

21 January 2018

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Osteopontin and the bone remodeling sequence. Colloidal-gold immunocytochemistry of an interfacial extracellular matrix protein

21 January 2018

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Chronic administration of 1,25-dihydroxyvitamin D3: increased bone but impaired mineralization

21 January 2018

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Role of vitamin D metabolites in the prevention of the osteopenia induced by ovariectomy in the axial and appendicular skeleton of the rat.

21 January 2018

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Premature aging in klotho mutant mice: cause or consequence?

21 January 2018

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Normal epidermal growth factor receptor signaling is dispensable for bone anabolic effects of parathyroid hormone

21 January 2018

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Guidelines for assessment of bone microstructure in rodents using micro-computed tomography

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Bone mineralization density distribution in health and disease.

21 January 2018

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25-Hydroxyvitamin D-24-hydroxylase (CYP24A1): its important role in the degradation of vitamin D.

21 January 2018

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25-Hydroxyvitamin D3 1alpha-hydroxylase and vitamin D synthesis

21 January 2018

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Altered bone development and an increase in FGF-23 expression in Enpp1(-/-) mice

21 January 2018

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Role of the mouse ank gene in control of tissue calcification and arthritis

21 January 2018

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Unique coexpression in osteoblasts of broadly expressed genes accounts for the spatial restriction of ECM mineralization to bone

21 January 2018

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Inorganic phosphate added exogenously or released from beta-glycerophosphate initiates mineralization of osteoid nodules in vitro

21 January 2018

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Inorganic phosphate regulates multiple genes during osteoblast differentiation, including Nrf2.

21 January 2018

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Phosphate regulates osteopontin gene transcription

21 January 2018

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Phosphate is a specific signal for induction of osteopontin gene expression

21 January 2018

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Osteopontin regulation by inorganic phosphate is ERK1/2-, protein kinase C-, and proteasome-dependent

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Pyrophosphate inhibits mineralization of osteoblast cultures by binding to mineral, up-regulating osteopontin, and inhibiting alkaline phosphatase activity

21 January 2018

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Concerted regulation of inorganic pyrophosphate and osteopontin by akp2, enpp1, and ank: an integrated model of the pathogenesis of mineralization disorders

21 January 2018

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FGF23 suppresses chondrocyte proliferation in the presence of soluble α-Klotho both in vitro and in vivo

21 January 2018

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Tissue-nonspecific alkaline phosphatase and plasma cell membrane glycoprotein-1 are central antagonistic regulators of bone mineralization

21 January 2018

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Functional characterization of osteoblasts and osteoclasts from alkaline phosphatase knockout mice

21 January 2018

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In vivo overexpression of tissue-nonspecific alkaline phosphatase increases skeletal mineralization and affects the phosphorylation status of osteopontin

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Proteolytic processing of osteopontin by PHEX and accumulation of osteopontin fragments in Hyp mouse bone, the murine model of X-linked hypophosphatemia

21 January 2018

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Bone proteins PHEX and DMP1 regulate fibroblastic growth factor Fgf23 expression in osteocytes through a common pathway involving FGF receptor (FGFR) signaling.

21 January 2018

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Identifiers

DOI

10.1002/JBMR.2606

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21 December 2017

release_oeucvqo7mvezva4xttgqc5226i

Fatcat ID

1 reference

Fatcat

https://api.fatcat.wiki/v0/release/oeucvqo7mvezva4xttgqc5226i

mapped directly with Wikidata item

24 November 2022

based on heuristic

PubMed ID

26235988

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21 December 2017