RhoA/Rho kinase up-regulate Bax to activate a mitochondrial death pathway and induce cardiomyocyte apoptosis (Q46387185)

21 December 2017

title

RhoA/Rho kinase up-regulate Bax to activate a mitochondrial death pathway and induce cardiomyocyte apoptosis (English)

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21 December 2017

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Dominic P Del Re

1

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21 December 2017

Shigeki Miyamoto

series ordinal

2

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21 December 2017

Joan Heller Brown

series ordinal

3

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21 December 2017

language of work or name

English

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publication date

18 January 2007

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21 December 2017

Journal of Biological Chemistry

published in

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21 December 2017

volume

282

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21 December 2017

issue

11

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21 December 2017

page(s)

8069-8078

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21 December 2017

Rho GTPases: biochemistry and biology

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Rho is required for Galphaq and alpha1-adrenergic receptor signaling in cardiomyocytes. Dissociation of Ras and Rho pathways

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The low molecular weight GTPase Rho regulates myofibril formation and organization in neonatal rat ventricular myocytes. Involvement of Rho kinase

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Rho/ROCK pathway contributes to the activation of extracellular signal-regulated kinase/GATA-4 during myocardial cell hypertrophy

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Galpha(12/13) mediates alpha(1)-adrenergic receptor-induced cardiac hypertrophy

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MAP kinase- and Rho-dependent signals interact to regulate gene expression but not actin morphology in cardiac muscle cells

21 January 2018

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The effects of the selective ROCK inhibitor, Y27632, on ET-1-induced hypertrophic response in neonatal rat cardiac myocytes--possible involvement of Rho/ROCK pathway in cardiac muscle cell hypertrophy

21 January 2018

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Cardiac-specific overexpression of RhoA results in sinus and atrioventricular nodal dysfunction and contractile failure

21 January 2018

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Inhibition of protein geranylgeranylation and RhoA/RhoA kinase pathway induces apoptosis in human endothelial cells

21 January 2018

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Anti-apoptotic effects of muscarinic receptor activation are mediated by Rho kinase

21 January 2018

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A balance of signaling by Rho family small GTPases RhoA, Rac1 and Cdc42 coordinates cytoskeletal morphology but not cell survival

21 January 2018

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Rho-regulated signals induce apoptosis in vitro and in vivo by a p53-independent, but Bcl2 dependent pathway.

21 January 2018

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Constitutively active Galphaq and Galpha13 trigger apoptosis through different pathways

21 January 2018

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Regulation of Apoptosis by α-Subunits of G12 and G13 Proteins via Apoptosis Signal-regulating Kinase-1

21 January 2018

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The pathophysiology of mitochondrial cell death

21 January 2018

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Movement of Bax from the cytosol to mitochondria during apoptosis

21 January 2018

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Bax is present as a high molecular weight oligomer/complex in the mitochondrial membrane of apoptotic cells

21 January 2018

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Bax oligomerization is required for channel-forming activity in liposomes and to trigger cytochrome c release from mitochondria

21 January 2018

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Pro-apoptotic cascade activates BID, which oligomerizes BAK or BAX into pores that result in the release of cytochrome c.

21 January 2018

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Bid, Bax, and lipids cooperate to form supramolecular openings in the outer mitochondrial membrane

21 January 2018

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Bax directly induces release of cytochrome c from isolated mitochondria

21 January 2018

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p53 activates the mitochondrial death pathway and apoptosis of ventricular myocytes independent of de novo gene transcription

21 January 2018

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Transcriptional activation of the cardiac myosin light chain 2 and atrial natriuretic factor genes by protein kinase C in neonatal rat ventricular myocytes

21 January 2018

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Myosin II activation promotes neurite retraction during the action of Rho and Rho-kinase.

21 January 2018

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Ca2+ dysregulation induces mitochondrial depolarization and apoptosis: role of Na+/Ca2+ exchanger and AKT.

21 January 2018

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Physical and functional interactions of Galphaq with Rho and its exchange factors

21 January 2018

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Increased expression and activity of RhoA are associated with increased DNA synthesis and reduced p27(Kip1) expression in the vasculature of hypertensive rats

21 January 2018

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21 January 2018

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Cytoprotective membrane-permeable peptides designed from the Bax-binding domain of Ku70.

21 January 2018

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Bax-induced caspase activation and apoptosis via cytochrome c release from mitochondria is inhibitable by Bcl-xL.

21 January 2018

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Auto-activation of the apoptosis protein Bax increases mitochondrial membrane permeability and is inhibited by Bcl-2

21 January 2018

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p53 and Nur77/TR3 - transcription factors that directly target mitochondria for cell death induction

21 January 2018

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Tumor suppressor p53 is a direct transcriptional activator of the human bax gene

21 January 2018

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Cardiomyocyte apoptosis induced by Galphaq signaling is mediated by permeability transition pore formation and activation of the mitochondrial death pathway.

21 January 2018

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Conformation of the Bax C-terminus regulates subcellular location and cell death

21 January 2018

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Bid induces the oligomerization and insertion of Bax into the outer mitochondrial membrane

21 January 2018

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Bax translocates to mitochondria of heart cells during simulated ischaemia: involvement of AMP-activated and p38 mitogen-activated protein kinases

21 January 2018

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Chronic inhibition of Rho kinase blunts the process of left ventricular hypertrophy leading to cardiac contractile dysfunction in hypertension-induced heart failure.

21 January 2018

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Live or let die: the cell's response to p53

21 January 2018

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Upregulation of small GTPase RhoA in the basilar artery from diabetic (mellitus) rats

21 January 2018

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Long-term inhibition of Rho-kinase suppresses left ventricular remodeling after myocardial infarction in mice

21 January 2018

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Inhibition of Rho-kinase protects the heart against ischemia/reperfusion injury.

21 January 2018

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Inhibition of Rho-kinase leads to rapid activation of phosphatidylinositol 3-kinase/protein kinase Akt and cardiovascular protection.

21 January 2018

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Activation of Rho-associated coiled-coil protein kinase 1 (ROCK-1) by caspase-3 cleavage plays an essential role in cardiac myocyte apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M604298200

21 January 2018

Identifiers

DOI

10.1074/JBC.M604298200

1 reference

21 December 2017

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21 December 2017