Ca2+ dysregulation induces mitochondrial depolarization and apoptosis: role of Na+/Ca2+ exchanger and AKT. (Q43415387)

23 November 2017

Ca2+ dysregulation induces mitochondrial depolarization and apoptosis: role of Na+/Ca2+ exchanger and AKT. (English)

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23 November 2017

Shigeki Miyamoto

1

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23 November 2017

Amy L Howes

2

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23 November 2017

John W Adams

3

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23 November 2017

Gerald W Dorn

4

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23 November 2017

Joan Heller Brown

5

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23 November 2017

language of work or name

English

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publication date

1 August 2005

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Journal of Biological Chemistry

23 November 2017

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23 November 2017

280

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23 November 2017

46

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23 November 2017

38505-38512

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Loss of a gp130 cardiac muscle cell survival pathway is a critical event in the onset of heart failure during biomechanical stress

23 November 2017

1 reference

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Enhanced Galphaq signaling: a common pathway mediates cardiac hypertrophy and apoptotic heart failure

21 January 2018

1 reference

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Apoptosis in heart: basic mechanisms and implications in cardiovascular diseases

21 January 2018

1 reference

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Inhibition of cardiac myocyte apoptosis improves cardiac function and abolishes mortality in the peripartum cardiomyopathy of Galpha(q) transgenic mice

21 January 2018

1 reference

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Mitochondria in apoptosis of ischemic heart

21 January 2018

1 reference

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Transient cardiac expression of constitutively active Galphaq leads to hypertrophy and dilated cardiomyopathy by calcineurin-dependent and independent pathways

21 January 2018

1 reference

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G-proteins in growth and apoptosis: lessons from the heart

21 January 2018

1 reference

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Adrenergic regulation of myocardial apoptosis

21 January 2018

1 reference

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Cardiomyocyte apoptosis induced by Galphaq signaling is mediated by permeability transition pore formation and activation of the mitochondrial death pathway.

21 January 2018

1 reference

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Akt-mediated cardiomyocyte survival pathways are compromised by G alpha q-induced phosphoinositide 4,5-bisphosphate depletion

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M505223200

Opening of the mitochondrial permeability transition pore causes depletion of mitochondrial and cytosolic NAD+ and is a causative event in the death of myocytes in postischemic reperfusion of the heart.

21 January 2018

1 reference

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BAX and BAK regulation of endoplasmic reticulum Ca2+: a control point for apoptosis

21 January 2018

1 reference

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Protection of cardiac mitochondria by diazoxide and protein kinase C: implications for ischemic preconditioning

21 January 2018

1 reference

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Mitochondrial ATP-sensitive potassium channels attenuate matrix Ca(2+) overload during simulated ischemia and reperfusion: possible mechanism of cardioprotection

21 January 2018

1 reference

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Mechanistically distinct steps in the mitochondrial death pathway triggered by oxidative stress in cardiac myocytes

21 January 2018

1 reference

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Mitochondria in cell death: novel targets for neuroprotection and cardioprotection

21 January 2018

1 reference

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Role of the mitochondrial permeability transition in myocardial disease

21 January 2018

1 reference

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The mitochondrial permeability transition, release of cytochrome c and cell death. Correlation with the duration of pore openings in situ

21 January 2018

1 reference

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Cytofluorometric detection of mitochondrial alterations in early CD95/Fas/APO-1-triggered apoptosis of Jurkat T lymphoma cells. Comparison of seven mitochondrion-specific fluorochromes.

21 January 2018

1 reference

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Cardiac excitation-contraction coupling

21 January 2018

1 reference

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Mitochondrial function as a determinant of recovery or death in cell response to injury.

21 January 2018

1 reference

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Calcium signal transmission between ryanodine receptors and mitochondria

21 January 2018

1 reference

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Inositol 1,4,5-trisphosphate directs Ca(2+) flow between mitochondria and the Endoplasmic/Sarcoplasmic reticulum: a role in regulating cardiac autonomic Ca(2+) spiking

21 January 2018

1 reference

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Calcium signal transmission between ryanodine receptors and mitochondria in cardiac muscle

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M505223200

Calcium, ATP, and ROS: a mitochondrial love-hate triangle

21 January 2018

1 reference

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Role of Akt signaling in mitochondrial survival pathway triggered by hypoxic preconditioning

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M505223200

Insulin-like growth factor-1 prevents loss of electrochemical gradient in cardiac muscle mitochondria via activation of PI 3 kinase/Akt pathway.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M505223200

Nuclear targeting of Akt enhances kinase activity and survival of cardiomyocytes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M505223200

Propagation of the apoptotic signal by mitochondrial waves

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M505223200

Cleavage of the plasma membrane Na+/Ca2+ exchanger in excitotoxicity

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M505223200

Rescue of cardiomyocyte dysfunction by phospholamban ablation does not prevent ventricular failure in genetic hypertrophy

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M505223200

Altered Na/Ca exchange activity in cardiac hypertrophy and heart failure: a new target for therapy?

21 January 2018

1 reference

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Functional adult myocardium in the absence of Na+-Ca2+ exchange: cardiac-specific knockout of NCX1

21 January 2018

1 reference

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Akt promotes survival of cardiomyocytes in vitro and protects against ischemia-reperfusion injury in mouse heart.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M505223200

Akt activation preserves cardiac function and prevents injury after transient cardiac ischemia in vivo

21 January 2018

1 reference

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Myoplasmic free calcium concentration reached during the twitch of an intact isolated cardiac cell and during calcium-induced release of calcium from the sarcoplasmic reticulum of a skinned cardiac cell from the adult rat or rabbit ventricle

21 January 2018

1 reference

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Expression of G qα and PLC-β in Scar and Border Tissue in Heart Failure Due to Myocardial Infarction

21 January 2018

1 reference

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Cardiac sarcolemmal Na(+)-Ca2+ exchange and Na(+)-K+ ATPase activities and gene expression in alloxan-induced diabetes in rats

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M505223200

21 January 2018

Identifiers

DOI

10.1074/JBC.M505223200

1 reference

23 November 2017

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