Metformin alleviates ageing cellular phenotypes in Hutchinson-Gilford progeria syndrome dermal fibroblasts (Q46418627)

22 December 2017

http://europepmc.org/abstract/MED/28192606

title

Metformin alleviates ageing cellular phenotypes in Hutchinson-Gilford progeria syndrome dermal fibroblasts (English)

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22 December 2017

http://europepmc.org/abstract/MED/28192606

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2

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28192606%20AND%20SRC:MED&resulttype=core&format=json

11 June 2020

author name string

Seul-Ki Park

series ordinal

1

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28192606%20AND%20SRC:MED&resulttype=core&format=json

11 June 2020

publication date

13 February 2017

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22 December 2017

http://europepmc.org/abstract/MED/28192606

published in

Experimental Dermatology

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28192606%20AND%20SRC:MED&resulttype=core&format=json

11 June 2020

volume

26

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28192606%20AND%20SRC:MED&resulttype=core&format=json

11 June 2020

issue

10

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28192606%20AND%20SRC:MED&resulttype=core&format=json

11 June 2020

page(s)

889-895

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Progeria: translational insights from cell biology

11 June 2020

cites work

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Mutant nuclear lamin A leads to progressive alterations of epigenetic control in premature aging

21 January 2018

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Recurrent de novo point mutations in lamin A cause Hutchinson–Gilford progeria syndrome

21 January 2018

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A lamin A protein isoform overexpressed in Hutchinson-Gilford progeria syndrome interferes with mitosis in progeria and normal cells

21 January 2018

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Accumulation of mutant lamin A causes progressive changes in nuclear architecture in Hutchinson-Gilford progeria syndrome

21 January 2018

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Metformin retards aging in C. elegans by altering microbial folate and methionine metabolism.

21 January 2018

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Metformin improves healthspan and lifespan in mice

21 January 2018

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A farnesyltransferase inhibitor prevents both the onset and late progression of cardiovascular disease in a progeria mouse model

21 January 2018

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A farnesyltransferase inhibitor improves disease phenotypes in mice with a Hutchinson-Gilford progeria syndrome mutation.

21 January 2018

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Progerin and telomere dysfunction collaborate to trigger cellular senescence in normal human fibroblasts

21 January 2018

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Methylene blue alleviates nuclear and mitochondrial abnormalities in progeria

21 January 2018

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All-trans retinoic acid and rapamycin normalize Hutchinson Gilford progeria fibroblast phenotype.

21 January 2018

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Vitamin D receptor signaling improves Hutchinson-Gilford progeria syndrome cellular phenotypes

21 January 2018

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Sulforaphane enhances progerin clearance in Hutchinson-Gilford progeria fibroblasts

21 January 2018

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Metformin suppresses ovarian cancer growth and metastasis with enhancement of cisplatin cytotoxicity in vivo.

21 January 2018

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Oligonol promotes anti-aging pathways via modulation of SIRT1-AMPK-Autophagy Pathway

21 January 2018

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Enhanced Viral Replication by Cellular Replicative Senescence

21 January 2018

1 reference

A biomarker that identifies senescent human cells in culture and in aging skin in vivo

21 January 2018

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The accumulation of un-repairable DNA damage in laminopathy progeria fibroblasts is caused by ROS generation and is prevented by treatment with N-acetyl cysteine

21 January 2018

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Cellular senescence: when bad things happen to good cells

21 January 2018

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Mitochondrial effectors of cellular senescence: beyond the free radical theory of aging

21 January 2018

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Effect of progerin on the accumulation of oxidized proteins in fibroblasts from Hutchinson Gilford progeria patients

21 January 2018

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Signaling pathway activation drift during aging: Hutchinson-Gilford Progeria Syndrome fibroblasts are comparable to normal middle-age and old-age cells

21 January 2018

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Mitochondrial oxidative stress caused by Sod2 deficiency promotes cellular senescence and aging phenotypes in the skin

21 January 2018

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Repression of the Antioxidant NRF2 Pathway in Premature Aging

21 January 2018

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Genomic instability in laminopathy-based premature aging

21 January 2018

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Lamin A-dependent nuclear defects in human aging

21 January 2018

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Breaking news: high-speed race ends in arrest--how oncogenes induce senescence.

21 January 2018

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Metformin decreases progerin expression and alleviates pathological defects of Hutchinson-Gilford progeria syndrome cells.

21 January 2018

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Inhibiting farnesylation of progerin prevents the characteristic nuclear blebbing of Hutchinson-Gilford progeria syndrome

21 January 2018

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Blocking protein farnesyltransferase improves nuclear blebbing in mouse fibroblasts with a targeted Hutchinson-Gilford progeria syndrome mutation.

21 January 2018

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Impact of farnesylation inhibitors on survival in Hutchinson-Gilford progeria syndrome.

21 January 2018

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21 January 2018

Identifiers

DOI

10.1111/EXD.13323

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28192606%20AND%20SRC:MED&resulttype=core&format=json

11 June 2020

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