Dissection of the BCL-2 family signaling network with stabilized alpha-helices of BCL-2 domains (Q46500385)

1 July 2019

title

Dissection of the BCL-2 family signaling network with stabilized alpha-helices of BCL-2 domains (English)

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1 July 2019

4

Loren D Walensky

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1 July 2019

author name string

Kenneth Pitter

series ordinal

1

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1 July 2019

Federico Bernal

series ordinal

2

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1 July 2019

James Labelle

series ordinal

3

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1 July 2019

language of work or name

English

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publication date

1 January 2008

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1 July 2019

published in

Methods in Enzymology

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1 July 2019

volume

446

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1 July 2019

page(s)

387-408

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1 July 2019

Bax forms multispanning monomers that oligomerize to permeabilize membranes during apoptosis

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7 January 2021

Bax oligomerization is required for channel-forming activity in liposomes and to trigger cytochrome c release from mitochondria

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7 January 2021

Cloning the chromosomal breakpoint of t(14;18) human lymphomas: clustering around JH on chromosome 14 and near a transcriptional unit on 18.

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7 January 2021

A rapid and sensitive sub-micro phosphorus determination

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7 January 2021

Mitochondria primed by death signals determine cellular addiction to antiapoptotic BCL-2 family members

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7 January 2021

BCL-2, BCL-X(L) sequester BH3 domain-only molecules preventing BAX- and BAK-mediated mitochondrial apoptosis

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7 January 2021

Nucleotide sequence of a t(14;18) chromosomal breakpoint in follicular lymphoma and demonstration of a breakpoint-cluster region near a transcriptionally active locus on chromosome 18.

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7 January 2021

Cell death: critical control points

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7 January 2021

Dual role of proapoptotic BAD in insulin secretion and beta cell survival

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7 January 2021

Bid induces the oligomerization and insertion of Bax into the outer mitochondrial membrane

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7 January 2021

Regulated targeting of BAX to mitochondria.

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7 January 2021

Enforced dimerization of BAX results in its translocation, mitochondrial dysfunction and apoptosis

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7 January 2021

Bcl-2 is an inner mitochondrial membrane protein that blocks programmed cell death

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7 January 2021

Role of Bax and Bak in mitochondrial morphogenesis

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7 January 2021

Hierarchical regulation of mitochondrion-dependent apoptosis by BCL-2 subfamilies

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7 January 2021

Bid, Bax, and lipids cooperate to form supramolecular openings in the outer mitochondrial membrane

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7 January 2021

BH3 domains of BH3-only proteins differentially regulate Bax-mediated mitochondrial membrane permeabilization both directly and indirectly

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7 January 2021

Distinct BH3 domains either sensitize or activate mitochondrial apoptosis, serving as prototype cancer therapeutics

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7 January 2021

Bid, a Bcl2 interacting protein, mediates cytochrome c release from mitochondria in response to activation of cell surface death receptors

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7 January 2021

Cardiolipin provides specificity for targeting of tBid to mitochondria

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7 January 2021

bcl-2-immunoglobulin transgenic mice demonstrate extended B cell survival and follicular lymphoproliferation

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7 January 2021

A membrane-targeted BID BCL-2 homology 3 peptide is sufficient for high potency activation of BAX in vitro

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7 January 2021

Structure of Bcl-xL-Bak peptide complex: recognition between regulators of apoptosis

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7 January 2021

A distinct pathway remodels mitochondrial cristae and mobilizes cytochrome c during apoptosis

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7 January 2021

Structure of Bax: coregulation of dimer formation and intracellular localization

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7 January 2021

Lipidic pore formation by the concerted action of proapoptotic BAX and tBID.

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7 January 2021

BIM and tBID are not mechanistically equivalent when assisting BAX to permeabilize bilayer membranes

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7 January 2021

The t(14;18) chromosome translocations involved in B-cell neoplasms result from mistakes in VDJ joining.

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7 January 2021

Mitochondrial permeabilization relies on BH3 ligands engaging multiple prosurvival Bcl-2 relatives, not Bak.

1 reference

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7 January 2021

Bcl-2 gene promotes haemopoietic cell survival and cooperates with c-myc to immortalize pre-B cells

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7 January 2021

A stapled BID BH3 helix directly binds and activates BAX

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7 January 2021

Activation of apoptosis in vivo by a hydrocarbon-stapled BH3 helix

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7 January 2021

Apoptosis initiated when BH3 ligands engage multiple Bcl-2 homologs, not Bax or Bak

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7 January 2021

Interaction with a membrane surface triggers a reversible conformational change in Bax normally associated with induction of apoptosis

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7 January 2021

The BCL-2 protein family: opposing activities that mediate cell death

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7 January 2021

Proapoptotic protein Bax heterodimerizes with Bcl-2 and homodimerizes with Bax via a novel domain (BH3) distinct from BH1 and BH2

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https://api.crossref.org/works/10.1016%2FS0076-6879%2808%2901623-6

7 January 2021

tBID, a membrane-targeted death ligand, oligomerizes BAK to release cytochrome c

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12 December 2020

Mitochondrial contact sites. Lipid composition and dynamics

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12 December 2020

Deregulated Bcl-2 gene expression selectively prolongs survival of growth factor-deprived hemopoietic cell lines.

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12 December 2020

Alternative promoters and exons, somatic mutation and deregulation of the Bcl-2-Ig fusion gene in lymphoma

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12 December 2020

Establishment of a cell-free system of neuronal apoptosis: comparison of premitochondrial, mitochondrial, and postmitochondrial phases

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12 December 2020

10.1016/S0076-6879(08)01623-6

Identifiers

DOI

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1 July 2019

PMC publication ID

6317341

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1 July 2019

PubMed publication ID

18603135

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1 July 2019