Mitochondrial permeabilization relies on BH3 ligands engaging multiple prosurvival Bcl-2 relatives, not Bak. (Q36118156)

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29 December 2019

title

Mitochondrial permeabilization relies on BH3 ligands engaging multiple prosurvival Bcl-2 relatives, not Bak (English)

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29 December 2019

1

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David C Huang

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29 December 2019

Jerry Adams

6

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29 December 2019

Ruth Kluck

7

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29 December 2019

author name string

Grant Dewson

2

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29 December 2019

Lin Chen

3

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29 December 2019

Stephanie C Coyne

4

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29 December 2019

language of work or name

English

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publication date

1 April 2007

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29 December 2019

published in

Journal of Cell Biology

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29 December 2019

volume

177

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issue

2

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29 December 2019

page(s)

277-287

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The Bcl-2 apoptotic switch in cancer development and therapy

29 December 2019

cites work

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Apoptosis initiated when BH3 ligands engage multiple Bcl-2 homologs, not Bax or Bak

2 October 2017

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Mitochondria primed by death signals determine cellular addiction to antiapoptotic BCL-2 family members

2 October 2017

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Life in the balance: how BH3-only proteins induce apoptosis.

2 October 2017

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2 October 2017

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2 October 2017

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Proapoptotic Bak is sequestered by Mcl-1 and Bcl-xL, but not Bcl-2, until displaced by BH3-only proteins

2 October 2017

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BH3 domains of BH3-only proteins differentially regulate Bax-mediated mitochondrial membrane permeabilization both directly and indirectly

2 October 2017

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Differential targeting of prosurvival Bcl-2 proteins by their BH3-only ligands allows complementary apoptotic function

2 October 2017

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The first alpha helix of Bax plays a necessary role in its ligand-induced activation by the BH3-only proteins Bid and PUMA.

2 October 2017

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Solution structure of prosurvival Mcl-1 and characterization of its binding by proapoptotic BH3-only ligands.

2 October 2017

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Cell death: critical control points

2 October 2017

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DNA damage response and MCL-1 destruction initiate apoptosis in adenovirus-infected cells

2 October 2017

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The structure of a Bcl-xL/Bim fragment complex: implications for Bim function

2 October 2017

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Proapoptotic BH3-only proteins trigger membrane integration of prosurvival Bcl-w and neutralize its activity

2 October 2017

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Elimination of Mcl-1 is required for the initiation of apoptosis following ultraviolet irradiation

2 October 2017

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Postnatal brain development and neural cell differentiation modulate mitochondrial Bax and BH3 peptide-induced cytochrome c release

2 October 2017

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The structure of Bcl-w reveals a role for the C-terminal residues in modulating biological activity

2 October 2017

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Mitochondria: releasing power for life and unleashing the machineries of death

2 October 2017

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Bid, Bax, and lipids cooperate to form supramolecular openings in the outer mitochondrial membrane

2 October 2017

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Distinct BH3 domains either sensitize or activate mitochondrial apoptosis, serving as prototype cancer therapeutics

2 October 2017

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Proapoptotic BAX and BAK: a requisite gateway to mitochondrial dysfunction and death

2 October 2017

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The combined functions of proapoptotic Bcl-2 family members bak and bax are essential for normal development of multiple tissues

2 October 2017

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Preservation of mitochondrial structure and function after Bid- or Bax-mediated cytochrome c release

2 October 2017

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The pro-apoptotic proteins, Bid and Bax, cause a limited permeabilization of the mitochondrial outer membrane that is enhanced by cytosol

2 October 2017

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Bax in murine thymus is a soluble monomeric protein that displays differential detergent-induced conformations

2 October 2017

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The release of cytochrome c from mitochondria: a primary site for Bcl-2 regulation of apoptosis

2 October 2017

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2 October 2017

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2 October 2017

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Hepatocyte-specific disruption of Bcl-xL leads to continuous hepatocyte apoptosis and liver fibrotic responses.

23 September 2018

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Phylogenomics of life-or-death switches in multicellular animals: Bcl-2, BH3-Only, and BNip families of apoptotic regulators

23 September 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/17452531

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Hierarchical regulation of mitochondrion-dependent apoptosis by BCL-2 subfamilies

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/17452531

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1083/JCB.200606065

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29 December 2019

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29 December 2019

PubMed publication ID

17452531

1 reference