PI-103, a dual inhibitor of Class IA phosphatidylinositide 3-kinase and mTOR, has antileukemic activity in AML. (Q46544691)

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8 January 2020

title

PI-103, a dual inhibitor of Class IA phosphatidylinositide 3-kinase and mTOR, has antileukemic activity in AML (English)

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8 January 2020

2

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8 January 2020

Valérie Bardet

3

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8 January 2020

Jerome Tamburini

4

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8 January 2020

Zachary A Knight

7

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8 January 2020

Norbert Ifrah

11

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8 January 2020

Didier Bouscary

15

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8 January 2020

author name string

S Park

1

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8 January 2020

N Gallay

5

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8 January 2020

L Willems

6

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8 January 2020

K M Shokat

8

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N Azar

9

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8 January 2020

F Viguié

10

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8 January 2020

F Dreyfus

12

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P Mayeux

13

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C Lacombe

14

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publication date

12 June 2008

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8 January 2020

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8 January 2020

volume

22

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8 January 2020

issue

9

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8 January 2020

page(s)

1698-1706

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https://scigraph.springernature.com/pub.10.1038/leu.2008.144

8 January 2020

exact match

0 references

cites work

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Survival of acute myeloid leukemia cells requires PI3 kinase activation

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Constitutive phosphoinositide 3-kinase/Akt activation represents a favorable prognostic factor in de novo acute myelogenous leukemia patients.

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Constitutive phosphorylation of Akt/PKB protein in acute myeloid leukemia: its significance as a prognostic variable

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Essential role for the p110 isoform in phosphoinositide 3-kinase activation and cell proliferation in acute myeloid leukemia

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TOR signaling in growth and metabolism

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mTOR regulates cell survival after etoposide treatment in primary AML cells

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Antileukemic activity of rapamycin in acute myeloid leukemia.

21 January 2018

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Mammalian target of rapamycin (mTOR) inhibition activates phosphatidylinositol 3-kinase/Akt by up-regulating insulin-like growth factor-1 receptor signaling in acute myeloid leukemia: rationale for therapeutic inhibition of both pathways.

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Isoform-specific phosphoinositide 3-kinase inhibitors from an arylmorpholine scaffold

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A pharmacological map of the PI3-K family defines a role for p110alpha in insulin signaling

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A dual phosphoinositide-3-kinase alpha/mTOR inhibitor cooperates with blockade of epidermal growth factor receptor in PTEN-mutant glioma

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A dual PI3 kinase/mTOR inhibitor reveals emergent efficacy in glioma

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mTOR, a new therapeutic target in acute myeloid leukemia

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Multidrug resistance-associated protein 1 expression is under the control of the phosphoinositide 3 kinase/Akt signal transduction network in human acute myelogenous leukemia blasts

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Proapoptotic activity and chemosensitizing effect of the novel Akt inhibitor perifosine in acute myelogenous leukemia cells

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A critical role for Lyn in acute myeloid leukemia.

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Pharmacologic characterization of a potent inhibitor of class I phosphatidylinositide 3-kinases.

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A selective inhibitor of the p110delta isoform of PI 3-kinase inhibits AML cell proliferation and survival and increases the cytotoxic effects of VP16

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inferred from DOI database lookup

7 January 2021

based on heuristic

The insulin-like growth factor-I receptor kinase inhibitor NVP-AEW541 induces apoptosis in acute myeloid leukemia cells exhibiting autocrine insulin-like growth factor-I secretion

1 reference

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