Survival of acute myeloid leukemia cells requires PI3 kinase activation (Q44408364)

2 December 2017

Survival of acute myeloid leukemia cells requires PI3 kinase activation (English)

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2 December 2017

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acute myeloid leukemia

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https://api.crossref.org/works/10.1182/BLOOD-2002-11-3429

25 December 2023

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https://api.crossref.org/works/10.1182/BLOOD-2002-11-3429

25 December 2023

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https://api.crossref.org/works/10.1182/BLOOD-2002-11-3429

25 December 2023

author name string

Qing Xu

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2 December 2017

Serge-Emile Simpson

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2 December 2017

Adam Bagg

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2 December 2017

Martin Carroll

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2 December 2017

Timothy J. Scialla

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A12702506

25 December 2023

language of work or name

English

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publication date

17 April 2003

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full work available at URL

2 December 2017

http://ashpublications.org/blood/article-pdf/102/3/972/1689001/h81503000972.pdf

file format

Portable Document Format

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https://api.crossref.org/works/10.1182/BLOOD-2002-11-3429

25 December 2023

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2 December 2017

102

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2 December 2017

3

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2 December 2017

972-980

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Oncogenic transcription factors in the human acute leukemias

2 December 2017

2

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https://api.crossref.org/works/10.1182/BLOOD-2002-11-3429

The fusion gene Cbfb-MYH11 blocks myeloid differentiation and predisposes mice to acute myelomonocytic leukaemia

25 December 2023

3

1 reference

https://api.crossref.org/works/10.1182/BLOOD-2002-11-3429

Two critical hits for promyelocytic leukemia

25 December 2023

5

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https://api.crossref.org/works/10.1182/BLOOD-2002-11-3429

Acute leukemia with promyelocytic features in PML/RARalpha transgenic mice

25 December 2023

6

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https://api.crossref.org/works/10.1182/BLOOD-2002-11-3429

AML1-ETO expression is directly involved in the development of acute myeloid leukemia in the presence of additional mutations

25 December 2023

7

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https://api.crossref.org/works/10.1182/BLOOD-2002-11-3429

FLT3 internal tandem duplication mutations in adult acute myeloid leukaemia define a high-risk group

25 December 2023

9

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https://api.crossref.org/works/10.1182/BLOOD-2002-11-3429

A FLT3 tyrosine kinase inhibitor is selectively cytotoxic to acute myeloid leukemia blasts harboring FLT3 internal tandem duplication mutations

25 December 2023

11

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https://api.crossref.org/works/10.1182/BLOOD-2002-11-3429

Molecular genetics of acute myeloid leukaemia

25 December 2023

12

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https://api.crossref.org/works/10.1182/BLOOD-2002-11-3429

PML/RARalpha and FLT3-ITD induce an APL-like disease in a mouse model

25 December 2023

13

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https://api.crossref.org/works/10.1182/BLOOD-2002-11-3429

Constitutive activation of mitogen-activated protein kinase pathway in acute leukemia cells

25 December 2023

16

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https://api.crossref.org/works/10.1182/BLOOD-2002-11-3429

Therapeutic targeting of the MEK/MAPK signal transduction module in acute myeloid leukemia

25 December 2023

18

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https://api.crossref.org/works/10.1182/BLOOD-2002-11-3429

Preferential induction of apoptosis for primary human leukemic stem cells

25 December 2023

19

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https://api.crossref.org/works/10.1182/BLOOD-2002-11-3429

Nuclear factor-kappaB is constitutively activated in primitive human acute myelogenous leukemia cells

25 December 2023

20

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https://api.crossref.org/works/10.1182/BLOOD-2002-11-3429

Direct targets of phosphoinositide 3-kinase products in membrane traffic and signal transduction

25 December 2023

21

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https://api.crossref.org/works/10.1182/BLOOD-2002-11-3429

Phosphatidylinositol-3' kinase is not required for mitogenesis or internalization of the Flt3/Flk2 receptor tyrosine kinase

25 December 2023

22

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https://api.crossref.org/works/10.1182/BLOOD-2002-11-3429

Mitogenic signalling and substrate specificity of the Flk2/Flt3 receptor tyrosine kinase in fibroblasts and interleukin 3-dependent hematopoietic cells

25 December 2023

23

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https://api.crossref.org/works/10.1182/BLOOD-2002-11-3429

Molecular cloning and characterisation of a novel putative protein-serine kinase related to the cAMP-dependent and protein kinase C families

25 December 2023

24

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https://api.crossref.org/works/10.1182/BLOOD-2002-11-3429

Molecular cloning of the akt oncogene and its human homologues AKT1 and AKT2: amplification of AKT1 in a primary human gastric adenocarcinoma

25 December 2023

25

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https://api.crossref.org/works/10.1182/BLOOD-2002-11-3429

The phosphatidylinositol 3-Kinase AKT pathway in human cancer

25 December 2023

26

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https://api.crossref.org/works/10.1182/BLOOD-2002-11-3429

Regulation of translation initiation by FRAP/mTOR

25 December 2023

27

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https://api.crossref.org/works/10.1182/BLOOD-2002-11-3429

The PTEN/MMAC1 tumor suppressor phosphatase functions as a negative regulator of the phosphoinositide 3-kinase/Akt pathway

25 December 2023

28

1 reference

https://api.crossref.org/works/10.1182/BLOOD-2002-11-3429

Internal tandem duplication of FLT3 associated with leukocytosis in acute promyelocytic leukemia. Leukemia Study Group of the Ministry of Health and Welfare (Kohseisho)

25 December 2023

29

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https://api.crossref.org/works/10.1182/BLOOD-2002-11-3429

Activating mutation of D835 within the activation loop of FLT3 in human hematologic malignancies

25 December 2023

30

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https://api.crossref.org/works/10.1182/BLOOD-2002-11-3429

Thrombopoietin, but not cytokines binding to gp130 protein-coupled receptors, activates MAPKp42/44, AKT, and STAT proteins in normal human CD34+ cells, megakaryocytes, and platelets

25 December 2023

31

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https://api.crossref.org/works/10.1182/BLOOD-2002-11-3429

A specific inhibitor of phosphatidylinositol 3-kinase, 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one (LY294002)

25 December 2023

33

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https://api.crossref.org/works/10.1182/BLOOD-2002-11-3429

TEL/platelet-derived growth factor receptor beta activates phosphatidylinositol 3 (PI3) kinase and requires PI3 kinase to regulate the cell cycle

25 December 2023

34

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https://api.crossref.org/works/10.1182/BLOOD-2002-11-3429

Dissociation of apoptosis from proliferation, protein kinase B activation, and BAD phosphorylation in interleukin-3-mediated phosphoinositide 3-kinase signaling

25 December 2023

35

1 reference

https://api.crossref.org/works/10.1182/BLOOD-2002-11-3429

Human acute myeloid leukemia is organized as a hierarchy that originates from a primitive hematopoietic cell

25 December 2023

36

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https://api.crossref.org/works/10.1182/BLOOD-2002-11-3429

A cell initiating human acute myeloid leukaemia after transplantation into SCID mice

25 December 2023

37

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https://api.crossref.org/works/10.1182/BLOOD-2002-11-3429

The role of Certican (everolimus, rad) in the many pathways of chronic rejection

25 December 2023

38

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https://api.crossref.org/works/10.1182/BLOOD-2002-11-3429

An inhibitor of mTOR reduces neoplasia and normalizes p70/S6 kinase activity in Pten+/- mice

25 December 2023

39

1 reference

https://api.crossref.org/works/10.1182/BLOOD-2002-11-3429

Enhanced sensitivity of PTEN-deficient tumors to inhibition of FRAP/mTOR.

25 December 2023

40

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https://api.crossref.org/works/10.1182/BLOOD-2002-11-3429

PTEN is inversely correlated with the cell survival factor Akt/PKB and is inactivated via multiple mechanismsin haematological malignancies

25 December 2023

41

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https://api.crossref.org/works/10.1182/BLOOD-2002-11-3429

The role of SHIP in growth factor induced signalling.

25 December 2023

42

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https://api.crossref.org/works/10.1182/BLOOD-2002-11-3429

The inositol 5-phosphatase SHIP is expressed as 145 and 135 kDa proteins in blood and bone marrow cells in vivo, whereas carboxyl-truncated forms of SHIP are generated by proteolytic cleavage in vitro.

25 December 2023

44

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https://api.crossref.org/works/10.1182/BLOOD-2002-11-3429

PTEN: The down side of PI 3-kinase signalling.

25 December 2023

45

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https://api.crossref.org/works/10.1182/BLOOD-2002-11-3429

25 December 2023

Identifiers

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2 December 2017

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