The insulin-like growth factor-I receptor kinase inhibitor NVP-AEW541 induces apoptosis in acute myeloid leukemia cells exhibiting autocrine insulin-like growth factor-I secretion (Q56995355)

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scientific article published on 15 March 2007

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English	The insulin-like growth factor-I receptor kinase inhibitor NVP-AEW541 induces apoptosis in acute myeloid leukemia cells exhibiting autocrine insulin-like growth factor-I secretion	scientific article published on 15 March 2007

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27 December 2019

The insulin-like growth factor-I receptor kinase inhibitor NVP-AEW541 induces apoptosis in acute myeloid leukemia cells exhibiting autocrine insulin-like growth factor-I secretion (English)

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27 December 2019

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acute myeloid leukemia

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apoptotic process

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Camilla Evangelisti

5

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27 December 2019

James A. McCubrey

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27 December 2019

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Tazzari PL

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27 December 2019

Tabellini G

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27 December 2019

Bortul R

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27 December 2019

Papa V

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27 December 2019

Grafone T

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27 December 2019

Martinelli G

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27 December 2019

Martelli AM

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15 March 2007

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27 December 2019

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27 December 2019

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27 December 2019

886-896

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27 December 2019

https://scigraph.springernature.com/pub.10.1038/sj.leu.2404643

0 references

The insulin-like growth factor system and cancer

1 reference

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IGF-I receptor signalling in transformation and differentiation

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Targeting insulin-like growth factor pathways.

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PI3-kinase/Akt is constitutively active in primary acute myeloid leukaemia cells and regulates survival and chemoresistance via NF-kappaB, Mapkinase and p53 pathways

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Multidrug resistance-associated protein 1 expression is under the control of the phosphoinositide 3 kinase/Akt signal transduction network in human acute myelogenous leukemia blasts

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The phosphoinositide 3-kinase/Akt pathway regulates cell cycle progression of HL60 human leukemia cells through cytoplasmic relocalization of the cyclin-dependent kinase inhibitor p27(Kip1) and control of cyclin D1 expression

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