Punicalagin attenuates palmitate-induced lipotoxicity in HepG2 cells by activating the Keap1-Nrf2 antioxidant defense system (Q46577839)

23 December 2017

http://europepmc.org/abstract/MED/26989875

title

Punicalagin attenuates palmitate-induced lipotoxicity in HepG2 cells by activating the Keap1-Nrf2 antioxidant defense system (English)

1 reference

23 December 2017

http://europepmc.org/abstract/MED/26989875

author

Xun Wang

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26989875%20AND%20SRC:MED&resulttype=core&format=json

1 June 2020

Zhihui Feng

6

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26989875%20AND%20SRC:MED&resulttype=core&format=json

1 June 2020

author name string

Chunhong Yan

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26989875%20AND%20SRC:MED&resulttype=core&format=json

1 June 2020

Wenyan Sun

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26989875%20AND%20SRC:MED&resulttype=core&format=json

1 June 2020

Jiangang Long

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26989875%20AND%20SRC:MED&resulttype=core&format=json

1 June 2020

Xuebo Liu

5

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26989875%20AND%20SRC:MED&resulttype=core&format=json

1 June 2020

Jiankang Liu

7

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26989875%20AND%20SRC:MED&resulttype=core&format=json

1 June 2020

publication date

15 March 2016

1 reference

23 December 2017

http://europepmc.org/abstract/MED/26989875

published in

Molecular Nutrition and Food Research

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26989875%20AND%20SRC:MED&resulttype=core&format=json

1 June 2020

volume

60

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26989875%20AND%20SRC:MED&resulttype=core&format=json

1 June 2020

issue

5

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26989875%20AND%20SRC:MED&resulttype=core&format=json

1 June 2020

page(s)

1139-1149

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26989875%20AND%20SRC:MED&resulttype=core&format=json

Nonalcoholic fatty liver disease

1 June 2020

cites work

1 reference

https://api.crossref.org/works/10.1002%2FMNFR.201500490

Diabetes and apoptosis: lipotoxicity

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FMNFR.201500490

Lipoapoptosis: its mechanism and its diseases

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FMNFR.201500490

Hepatic lipotoxicity and the pathogenesis of nonalcoholic steatohepatitis: The central role of nontriglyceride fatty acid metabolites

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FMNFR.201500490

Molecular mechanisms of lipotoxicity in nonalcoholic fatty liver disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FMNFR.201500490

Role of obesity and lipotoxicity in the development of nonalcoholic steatohepatitis: pathophysiology and clinical implications

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FMNFR.201500490

Role of oxidative stress in the pathogenesis of nonalcoholic steatohepatitis

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FMNFR.201500490

Role of Nrf2 in oxidative stress and toxicity

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FMNFR.201500490

The Nrf2 cell defence pathway: Keap1-dependent and -independent mechanisms of regulation

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FMNFR.201500490

Regulatory mechanisms controlling gene expression mediated by the antioxidant response element

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FMNFR.201500490

The Dual Role of Nrf2 in Nonalcoholic Fatty Liver Disease: Regulation of Antioxidant Defenses and Hepatic Lipid Metabolism

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FMNFR.201500490

Protective effects of matrine against progression of high-fructose diet-induced steatohepatitis by enhancing antioxidant and anti-inflammatory defences involving Nrf2 translocation

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FMNFR.201500490

Enhanced expression of Nrf2 in mice attenuates the fatty liver produced by a methionine- and choline-deficient diet

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FMNFR.201500490

Loss of Nrf2 markedly exacerbates nonalcoholic steatohepatitis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FMNFR.201500490

Transcription factor Nrf2 regulates SHP and lipogenic gene expression in hepatic lipid metabolism

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FMNFR.201500490

The emerging role of Nrf2 in mitochondrial function

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FMNFR.201500490

Role of mitochondria in nonalcoholic fatty liver disease--from origin to propagation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FMNFR.201500490

Adaptation of hepatic mitochondrial function in humans with non-alcoholic fatty liver is lost in steatohepatitis

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FMNFR.201500490

Excessive hepatic mitochondrial TCA cycle and gluconeogenesis in humans with nonalcoholic fatty liver disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FMNFR.201500490

NASH: a mitochondrial disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FMNFR.201500490

Nrf2 impacts cellular bioenergetics by controlling substrate availability for mitochondrial respiration.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FMNFR.201500490

Nrf2 affects the efficiency of mitochondrial fatty acid oxidation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FMNFR.201500490

Nrf2 protects mitochondrial decay by oxidative stress

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FMNFR.201500490

Mitochondrial dysfunction in obesity-associated nonalcoholic fatty liver disease: the protective effects of pomegranate with its active component punicalagin

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FMNFR.201500490

Punicalagin Induces Nrf2/HO-1 Expression via Upregulation of PI3K/AKT Pathway and Inhibits LPS-Induced Oxidative Stress in RAW264.7 Macrophages

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FMNFR.201500490

Endurance exercise causes mitochondrial and oxidative stress in rat liver: effects of a combination of mitochondrial targeting nutrients

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FMNFR.201500490

Mammalian MAPK signal transduction pathways activated by stress and inflammation: a 10-year update

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FMNFR.201500490

The Ras GTPase-activating-like protein IQGAP1 mediates Nrf2 protein activation via the mitogen-activated protein kinase/extracellular signal-regulated kinase (ERK) kinase (MEK)-ERK pathway.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FMNFR.201500490

Erk activation is required for Nrf2 nuclear localization during pyrrolidine dithiocarbamate induction of glutamate cysteine ligase modulatory gene expression in HepG2 cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FMNFR.201500490

Long term nutritional intake and the risk for non-alcoholic fatty liver disease (NAFLD): a population based study

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FMNFR.201500490

The intake of high fat diet with different trans fatty acid levels differentially induces oxidative stress and non alcoholic fatty liver disease (NAFLD) in rats

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FMNFR.201500490

Hepatocyte Death: A Clear and Present Danger

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FMNFR.201500490

Antioxidant and hepatoprotective activity of punicalagin and punicalin on carbon tetrachloride-induced liver damage in rats

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FMNFR.201500490

Mitochondrial dysfunction and oxidative stress in the pathogenesis of alcohol- and obesity-induced fatty liver diseases

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FMNFR.201500490

The adaptive endoplasmic reticulum stress response to lipotoxicity in progressive human nonalcoholic fatty liver disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FMNFR.201500490

JNK1-dependent PUMA expression contributes to hepatocyte lipoapoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FMNFR.201500490

Inhibition of JNK along with activation of ERK1/2 MAPK pathways improve steatohepatitis among the rats

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FMNFR.201500490

Ajoene, a stable garlic by-product, has an antioxidant effect through Nrf2-mediated glutamate-cysteine ligase induction in HepG2 cells and primary hepatocytes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FMNFR.201500490

Quercetin modulates Nrf2 and glutathione-related defenses in HepG2 cells: Involvement of p38.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FMNFR.201500490

Hydroxytyrosol induces antioxidant/detoxificant enzymes and Nrf2 translocation via extracellular regulated kinases and phosphatidylinositol-3-kinase/protein kinase B pathways in HepG2 cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FMNFR.201500490

21 January 2018

Identifiers

DOI

10.1002/MNFR.201500490

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26989875%20AND%20SRC:MED&resulttype=core&format=json

1 June 2020

1 reference