The Dual Role of Nrf2 in Nonalcoholic Fatty Liver Disease: Regulation of Antioxidant Defenses and Hepatic Lipid Metabolism (Q38539752)

3 September 2017

6 references

21 March 2019

7 October 2019

11 December 2019

22 December 2019

18 December 2020

29 April 2021

The Dual Role of Nrf2 in Nonalcoholic Fatty Liver Disease: Regulation of Antioxidant Defenses and Hepatic Lipid Metabolism (English)

1 reference

metabolic dysfunction–associated steatotic liver disease

3 September 2017

4 references

21 March 2019

7 October 2019

11 December 2019

22 December 2019

human digestive system

1 reference

7 October 2019

1 reference

11 December 2019

1 reference

22 December 2019

1 reference

18 December 2020

nuclear factor erythroid 2-related factor 2

1 reference

29 April 2021

1 reference

3

0 references

author name string

Sílvia S Chambel

series ordinal

1

1 reference

PMCID

4450261

3 September 2017

Andreia Santos-Gonçalves

series ordinal

2

1 reference

PMCID

4450261

3 September 2017

language of work or name

English

0 references

publication date

18 May 2015

7 references

BioMed Research International

3 September 2017

21 March 2019

7 October 2019

11 December 2019

22 December 2019

18 December 2020

29 April 2021

7 references

3 September 2017

21 March 2019

7 October 2019

11 December 2019

22 December 2019

18 December 2020

29 April 2021

2015

1 reference

3 September 2017

597134

1 reference

Creative Commons Attribution 3.0 Unported

3 September 2017

6 references

21 March 2019

7 October 2019

11 December 2019

22 December 2019

18 December 2020

on focus list of Wikimedia project

29 April 2021

copyright status

copyrighted

0 references

ScienceSource

0 references

cites work

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Nrf2 deficiency improves glucose tolerance in mice fed a high-fat diet

6 September 2017

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Nrf2: a potential target for new therapeutics in liver disease

6 September 2017

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Assurance of mitochondrial integrity and mammalian longevity by the p62-Keap1-Nrf2-Nqo1 cascade

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Activation of stress signaling pathways by electrophilic oxidized and nitrated lipids

6 September 2017

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Nrf2 protects against 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)-induced oxidative injury and steatohepatitis

6 September 2017

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Bardoxolone methyl and kidney function in CKD with type 2 diabetes

6 September 2017

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6 September 2017

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Endoplasmic reticulum stress in liver disease

6 September 2017

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The triterpenoid 2-cyano-3,12-dioxooleana-1,9-dien-28-oic-acid methyl ester has potent anti-diabetic effects in diet-induced diabetic mice and Lepr(db/db) mice

6 September 2017

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Transcription factor Nrf2 regulates SHP and lipogenic gene expression in hepatic lipid metabolism

6 September 2017

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6 September 2017

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Proteomic analysis of Nrf2 deficient transgenic mice reveals cellular defence and lipid metabolism as primary Nrf2-dependent pathways in the liver.

6 September 2017

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Enhanced expression of Nrf2 in mice attenuates the fatty liver produced by a methionine- and choline-deficient diet

6 September 2017

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The selective autophagy substrate p62 activates the stress responsive transcription factor Nrf2 through inactivation of Keap1

6 September 2017

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Nrf2 the rescue: effects of the antioxidative/electrophilic response on the liver

6 September 2017

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Electron transport chain-dependent and -independent mechanisms of mitochondrial H2O2 emission during long-chain fatty acid oxidation

6 September 2017

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Role of Nrf2 in prevention of high-fat diet-induced obesity by synthetic triterpenoid CDDO-imidazolide

6 September 2017

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Genetic versus chemoprotective activation of Nrf2 signaling: overlapping yet distinct gene expression profiles between Keap1 knockout and triterpenoid-treated mice.

6 September 2017

1 reference

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Altered hepatic triglyceride content after partial hepatectomy without impaired liver regeneration in multiple murine genetic models.

6 September 2017

1 reference

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Nrf2 signaling: an adaptive response pathway for protection against environmental toxic insults

6 September 2017

1 reference

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Impaired liver regeneration in Nrf2 knockout mice: role of ROS-mediated insulin/IGF-1 resistance

6 September 2017

1 reference

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Enhancing expression of Nrf2-driven genes protects the blood brain barrier after brain injury

6 September 2017

1 reference

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Emerging role of Nrf2 in protecting against hepatic and gastrointestinal disease

6 September 2017

1 reference

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Pharmacodynamic characterization of chemopreventive triterpenoids as exceptionally potent inducers of Nrf2-regulated genes.

6 September 2017

1 reference

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Two-site substrate recognition model for the Keap1-Nrf2 system: a hinge and latch mechanism

6 September 2017

1 reference

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Cell survival responses to environmental stresses via the Keap1-Nrf2-ARE pathway

6 September 2017

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Metabolic syndrome--a new world-wide definition. A Consensus Statement from the International Diabetes Federation

6 September 2017

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6 September 2017

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The role of Keap1 in cellular protective responses

6 September 2017

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Coordination of ER and oxidative stress signaling: the PERK/Nrf2 signaling pathway

6 September 2017

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Nrf2 is essential for the chemopreventive efficacy of oltipraz against urinary bladder carcinogenesis

6 September 2017

1 reference

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A strategy for cancer prevention: stimulation of the Nrf2-ARE signaling pathway

6 September 2017

1 reference

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Decline in transcriptional activity of Nrf2 causes age-related loss of glutathione synthesis, which is reversible with lipoic acid

6 September 2017

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6 September 2017

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Regulatory mechanisms controlling gene expression mediated by the antioxidant response element

6 September 2017

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Prevalence of the metabolic syndrome among US adults: findings from the third National Health and Nutrition Examination Survey

6 September 2017

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Sensitivity to carcinogenesis is increased and chemoprotective efficacy of enzyme inducers is lost in nrf2 transcription factor-deficient mice

6 September 2017

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Functional antioxidant responsive elements.

6 September 2017

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The antioxidant responsive element. Activation by oxidative stress and identification of the DNA consensus sequence required for functional activity

6 September 2017

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Sulforaphane attenuates hepatic fibrosis via NF-E2-related factor 2-mediated inhibition of transforming growth factor-β/Smad signaling

6 September 2017

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SCF/{beta}-TrCP promotes glycogen synthase kinase 3-dependent degradation of the Nrf2 transcription factor in a Keap1-independent manner.

6 September 2017

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The synthetic triterpenoids, CDDO and CDDO-imidazolide, are potent inducers of heme oxygenase-1 and Nrf2/ARE signaling

14 September 2017

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14 September 2017

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Sulforaphane inhibits mitochondrial permeability transition and oxidative stress

14 September 2017

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Oncogenic KRAS confers chemoresistance by upregulating NRF2.

27 September 2017

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Lipid analysis reveals quiescent and regenerating liver-specific populations of lipid droplets

23 June 2018

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Biosynthesis and secretion of triacylglycerol in rat liver after partial hepatectomy

23 June 2018

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Nrf2 inhibits hepatic iron accumulation and counteracts oxidative stress-induced liver injury in nutritional steatohepatitis.

23 June 2018

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Deletion of nuclear factor-E2-related factor-2 leads to rapid onset and progression of nutritional steatohepatitis in mice

31 August 2018

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Loss of Nrf2 markedly exacerbates nonalcoholic steatohepatitis.

31 August 2018

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Health care utilization and costs by metabolic syndrome risk factors.

31 August 2018

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Age-accelerated atherosclerosis correlates with failure to upregulate antioxidant genes

31 August 2018

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Efficacy and safety of oral fumarate in patients with relapsing-remitting multiple sclerosis: a multicentre, randomised, double-blind, placebo-controlled phase IIb study

31 August 2018

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The Nrf2 transcription factor protects from toxin-induced liver injury and fibrosis

31 August 2018

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31 August 2018

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Potent protection against aflatoxin-induced tumorigenesis through induction of Nrf2-regulated pathways by the triterpenoid 1-[2-cyano-3-,12-dioxooleana-1,9(11)-dien-28-oyl]imidazole

31 August 2018

1 reference

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Transcriptional regulation of NF-E2 p45-related factor (NRF2) expression by the aryl hydrocarbon receptor-xenobiotic response element signaling pathway: direct cross-talk between phase I and II drug-metabolizing enzymes

31 August 2018

1 reference

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EPR imaging of reducing activity in Nrf2 transcriptional factor-deficient mice

31 August 2018

1 reference

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Hepatic steatosis: innocent bystander or guilty party?

31 August 2018

1 reference

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Transcription factor NRF2 protects mice against dietary iron-induced liver injury by preventing hepatocytic cell death

31 August 2018

1 reference

Crossref

https://api.crossref.org/works/10.1155%2F2015%2F597134

Chemoprotective properties of phenylpropenoids, bis(benzylidene)cycloalkanones, and related Michael reaction acceptors: correlation of potencies as phase 2 enzyme inducers and radical scavengers

21 January 2018

1 reference

12 December 2020

Dysregulated expression of fatty acid oxidation enzymes and iron-regulatory genes in livers of Nrf2-null mice

1 reference

12 December 2020

Deletion of Nrf2 leads to rapid progression of steatohepatitis in mice fed atherogenic plus high-fat diet

1 reference

12 December 2020

Uptake and metabolism of triglycerides by the rat liver

1 reference

12 December 2020

Effects of a high-fat diet on energy metabolism and ROS production in rat liver

1 reference

12 December 2020

Differential expressions of antioxidant status in aging rats: the role of transcriptional factor Nrf2 and MAPK signaling pathway

1 reference

12 December 2020

Identifiers

DOI

10.1155/2015/597134

1 reference

3 September 2017

1 reference

3 September 2017

1 reference

PMCID

4450261