Antibody-Drug Conjugates (ADCs) Derived from Interchain Cysteine Cross-Linking Demonstrate Improved Homogeneity and Other Pharmacological Properties over Conventional Heterogeneous ADCs (Q46674963)

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scientific article published on 22 September 2015

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English	Antibody-Drug Conjugates (ADCs) Derived from Interchain Cysteine Cross-Linking Demonstrate Improved Homogeneity and Other Pharmacological Properties over Conventional Heterogeneous ADCs	scientific article published on 22 September 2015

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scholarly article

1 reference

Europe PubMed Central

PubMed publication ID

24 December 2017

http://europepmc.org/abstract/MED/26393951

Antibody-Drug Conjugates (ADCs) Derived from Interchain Cysteine Cross-Linking Demonstrate Improved Homogeneity and Other Pharmacological Properties over Conventional Heterogeneous ADCs (English)

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Europe PubMed Central

PubMed publication ID

24 December 2017

http://europepmc.org/abstract/MED/26393951

author name string

Christopher R Behrens

1

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24 December 2017

http://europepmc.org/abstract/MED/26393951

Edward H Ha

2

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24 December 2017

http://europepmc.org/abstract/MED/26393951

Lawrence L Chinn

3

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24 December 2017

http://europepmc.org/abstract/MED/26393951

Simeon Bowers

4

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24 December 2017

http://europepmc.org/abstract/MED/26393951

Gary Probst

5

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24 December 2017

http://europepmc.org/abstract/MED/26393951

Maureen Fitch-Bruhns

6

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24 December 2017

http://europepmc.org/abstract/MED/26393951

Jorge Monteon

7

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http://europepmc.org/abstract/MED/26393951

Amanda Valdiosera

8

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24 December 2017

http://europepmc.org/abstract/MED/26393951

Abel Bermudez

9

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24 December 2017

http://europepmc.org/abstract/MED/26393951

Sindy Liao-Chan

10

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24 December 2017

http://europepmc.org/abstract/MED/26393951

Tiffany Wong

11

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24 December 2017

http://europepmc.org/abstract/MED/26393951

Jonathan Melnick

12

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24 December 2017

http://europepmc.org/abstract/MED/26393951

Jan-Willem Theunissen

13

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24 December 2017

http://europepmc.org/abstract/MED/26393951

Mark R Flory

14

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24 December 2017

http://europepmc.org/abstract/MED/26393951

Derrick Houser

15

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24 December 2017

http://europepmc.org/abstract/MED/26393951

Kristy Venstrom

16

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24 December 2017

http://europepmc.org/abstract/MED/26393951

Zoia Levashova

17

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24 December 2017

http://europepmc.org/abstract/MED/26393951

Paul Sauer

18

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24 December 2017

http://europepmc.org/abstract/MED/26393951

Thi-Sau Migone

19

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24 December 2017

http://europepmc.org/abstract/MED/26393951

Edward H van der Horst

20

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24 December 2017

http://europepmc.org/abstract/MED/26393951

Randall L Halcomb

21

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24 December 2017

http://europepmc.org/abstract/MED/26393951

David Y Jackson

22

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24 December 2017

http://europepmc.org/abstract/MED/26393951

language of work or name

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publication date

22 September 2015

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24 December 2017

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Molecular Pharmaceutics

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24 December 2017

http://europepmc.org/abstract/MED/26393951

12

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http://europepmc.org/abstract/MED/26393951

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3986-3998

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24 December 2017

http://europepmc.org/abstract/MED/26393951

cAC10-vcMMAE, an anti-CD30–monomethyl auristatin E conjugate with potent and selective antitumor activity

1 reference

https://pubmed.ncbi.nlm.nih.gov/26393951

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Development of potent monoclonal antibody auristatin conjugates for cancer therapy

1 reference

https://pubmed.ncbi.nlm.nih.gov/26393951

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effects of drug loading on the antitumor activity of a monoclonal antibody drug conjugate

1 reference

https://pubmed.ncbi.nlm.nih.gov/26393951

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

In vivo drug-linker stability of an anti-CD30 dipeptide-linked auristatin immunoconjugate

1 reference

https://pubmed.ncbi.nlm.nih.gov/26393951

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Arming antibodies for cancer therapy

1 reference

https://pubmed.ncbi.nlm.nih.gov/26393951

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Enhanced activity of monomethylauristatin F through monoclonal antibody delivery: effects of linker technology on efficacy and toxicity

1 reference

https://pubmed.ncbi.nlm.nih.gov/26393951

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Site-specific conjugation of a cytotoxic drug to an antibody improves the therapeutic index.

1 reference

https://pubmed.ncbi.nlm.nih.gov/26393951

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Novel peptide linkers for highly potent antibody-auristatin conjugate

1 reference

https://pubmed.ncbi.nlm.nih.gov/26393951

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Physicochemical stability of the antibody-drug conjugate Trastuzumab-DM1: changes due to modification and conjugation processes

1 reference

https://pubmed.ncbi.nlm.nih.gov/26393951

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Engineered thio-trastuzumab-DM1 conjugate with an improved therapeutic index to target human epidermal growth factor receptor 2-positive breast cancer

1 reference

https://pubmed.ncbi.nlm.nih.gov/26393951

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Analytical methods for physicochemical characterization of antibody drug conjugates

1 reference

https://pubmed.ncbi.nlm.nih.gov/26393951

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Impact of drug conjugation on pharmacokinetics and tissue distribution of anti-STEAP1 antibody-drug conjugates in rats

1 reference

https://pubmed.ncbi.nlm.nih.gov/26393951

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Conjugation site modulates the in vivo stability and therapeutic activity of antibody-drug conjugates.

1 reference

https://pubmed.ncbi.nlm.nih.gov/26393951

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Native intact mass determination of antibodies conjugated with monomethyl Auristatin E and F at interchain cysteine residues.

1 reference

https://pubmed.ncbi.nlm.nih.gov/26393951

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Antibody-drug conjugates in cancer therapy

1 reference

https://pubmed.ncbi.nlm.nih.gov/26393951

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Location matters: site of conjugation modulates stability and pharmacokinetics of antibody drug conjugates

1 reference

https://pubmed.ncbi.nlm.nih.gov/26393951

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Maturing antibody-drug conjugate pipeline hits 30.

1 reference

https://pubmed.ncbi.nlm.nih.gov/26393951

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Antibody-drug conjugate (ADC) clinical pipeline: a review

1 reference

https://pubmed.ncbi.nlm.nih.gov/26393951

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Antibody-drug conjugates: present and future.

1 reference

https://pubmed.ncbi.nlm.nih.gov/26393951

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Production of site-specific antibody-drug conjugates using optimized non-natural amino acids in a cell-free expression system

1 reference

https://pubmed.ncbi.nlm.nih.gov/26393951

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A general approach to site-specific antibody drug conjugates

1 reference

https://pubmed.ncbi.nlm.nih.gov/26393951

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Bridging disulfides for stable and defined antibody drug conjugates

1 reference

https://pubmed.ncbi.nlm.nih.gov/26393951

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Aldehyde tag coupled with HIPS chemistry enables the production of ADCs conjugated site-specifically to different antibody regions with distinct in vivo efficacy and PK outcomes

1 reference

https://pubmed.ncbi.nlm.nih.gov/26393951

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Next generation maleimides enable the controlled assembly of antibody-drug conjugates via native disulfide bond bridging

1 reference

https://pubmed.ncbi.nlm.nih.gov/26393951

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Site-specific trastuzumab maytansinoid antibody-drug conjugates with improved therapeutic activity through linker and antibody engineering

1 reference

https://pubmed.ncbi.nlm.nih.gov/26393951

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mild method for succinimide hydrolysis on ADCs: impact on ADC potency, stability, exposure, and efficacy

1 reference

https://pubmed.ncbi.nlm.nih.gov/26393951

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Methods to Make Homogenous Antibody Drug Conjugates

1 reference

https://pubmed.ncbi.nlm.nih.gov/26393951

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Antitumor activity of an anti-CD98 antibody.

1 reference

https://pubmed.ncbi.nlm.nih.gov/26393951

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Site-Specific Conjugation of Monomethyl Auristatin E to Anti-CD30 Antibodies Improves Their Pharmacokinetics and Therapeutic Index in Rodent Models

1 reference

https://pubmed.ncbi.nlm.nih.gov/26393951

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A plug-and-play approach to antibody-based therapeutics via a chemoselective dual click strategy.

1 reference

https://pubmed.ncbi.nlm.nih.gov/26393951

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

In Vitro and In Vivo Evaluation of Cysteine Rebridged Trastuzumab-MMAE Antibody Drug Conjugates with Defined Drug-to-Antibody Ratios.

1 reference

https://pubmed.ncbi.nlm.nih.gov/26393951

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Reducing hydrophobicity of homogeneous antibody-drug conjugates improves pharmacokinetics and therapeutic index

1 reference

https://pubmed.ncbi.nlm.nih.gov/26393951

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1021/ACS.MOLPHARMACEUT.5B00432

1 reference

Europe PubMed Central

PubMed publication ID

24 December 2017

http://europepmc.org/abstract/MED/26393951

PMC publication ID

0 references

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

24 December 2017

http://europepmc.org/abstract/MED/26393951

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