Hepatocyte nuclear factor-4alpha is essential for glucose-stimulated insulin secretion by pancreatic beta-cells (Q46868194)

26 December 2017

title

Hepatocyte nuclear factor-4alpha is essential for glucose-stimulated insulin secretion by pancreatic beta-cells (English)

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26 December 2017

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11

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26 December 2017

Haruo Kasai

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26 December 2017

author name string

Atsuko Miura

1

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26 December 2017

Kazuya Yamagata

2

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26 December 2017

Masafumi Kakei

3

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26 December 2017

Hiroyasu Hatakeyama

4

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26 December 2017

Noriko Takahashi

5

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26 December 2017

Kenji Fukui

6

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26 December 2017

Takao Nammo

7

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26 December 2017

Kazue Yoneda

8

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26 December 2017

Yusuke Inoue

9

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26 December 2017

Frances M Sladek

10

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26 December 2017

Junichiro Miyagawa

13

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26 December 2017

Frank J Gonzalez

14

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26 December 2017

Iichiro Shimomura

15

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26 December 2017

language of work or name

English

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publication date

23 December 2005

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26 December 2017

Journal of Biological Chemistry

published in

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26 December 2017

volume

281

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26 December 2017

issue

8

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26 December 2017

page(s)

5246-5257

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26 December 2017

Liver-enriched transcription factor HNF-4 is a novel member of the steroid hormone receptor superfamily

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Molecular mechanisms and clinical pathophysiology of maturity-onset diabetes of the young

21 January 2018

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Mutations in the hepatocyte nuclear factor-4alpha gene in maturity-onset diabetes of the young (MODY1)

21 January 2018

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The maturity-onset diabetes of the young (MODY1) transcription factor HNF4alpha regulates expression of genes required for glucose transport and metabolism

21 January 2018

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R127W-HNF-4alpha is a loss of function mutation but not a rare polymorphism and causes Type II diabetes in a Japanese family with MODY1.

21 January 2018

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Altered insulin secretory responses to glucose in subjects with a mutation in the MODY1 gene on chromosome 20.

21 January 2018

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Diminished insulin and glucagon secretory responses to arginine in nondiabetic subjects with a mutation in the hepatocyte nuclear factor-4alpha/MODY1 gene

21 January 2018

1 reference

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A common polymorphism in the upstream promoter region of the hepatocyte nuclear factor-4 alpha gene on chromosome 20q is associated with type 2 diabetes and appears to contribute to the evidence for linkage in an ashkenazi jewish population.

21 January 2018

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Genetic variation near the hepatocyte nuclear factor-4 alpha gene predicts susceptibility to type 2 diabetes

21 January 2018

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A transcriptional hierarchy involved in mammalian cell-type specification

21 January 2018

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Mutations in the hepatocyte nuclear factor-1alpha gene in maturity-onset diabetes of the young (MODY3)

21 January 2018

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Hepatocyte nuclear factor 4alpha (nuclear receptor 2A1) is essential for maintenance of hepatic gene expression and lipid homeostasis

21 January 2018

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Tissue-specific knockout of the insulin receptor in pancreatic beta cells creates an insulin secretory defect similar to that in type 2 diabetes.

21 January 2018

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Functional characterization of the HNF4alpha isoform (HNF4alpha8) expressed in pancreatic beta-cells.

21 January 2018

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Overexpression of dominant-negative mutant hepatocyte nuclear fctor-1 alpha in pancreatic beta-cells causes abnormal islet architecture with decreased expression of E-cadherin, reduced beta-cell proliferation, and diabetes.

21 January 2018

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Fusion pore dynamics and insulin granule exocytosis in the pancreatic islet

21 January 2018

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The HNF-1 target collectrin controls insulin exocytosis by SNARE complex formation

21 January 2018

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Switch to anaerobic glucose metabolism with NADH accumulation in the beta-cell model of mitochondrial diabetes. Characteristics of betaHC9 cells deficient in mitochondrial DNA transcription

21 January 2018

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Defective pancreatic beta-cell glycolytic signaling in hepatocyte nuclear factor-1alpha-deficient mice

21 January 2018

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Identification of a familial hyperinsulinism-causing mutation in the sulfonylurea receptor 1 that prevents normal trafficking and function of KATP channels

21 January 2018

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Improved patch-clamp techniques for high-resolution current recording from cells and cell-free membrane patches

21 January 2018

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A transcription factor regulatory circuit in differentiated pancreatic cells

21 January 2018

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Loss of HNF-1alpha function in mice leads to abnormal expression of genes involved in pancreatic islet development and metabolism

21 January 2018

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Beta-cell mitochondria in the regulation of insulin secretion: a new culprit in type II diabetes

21 January 2018

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Reconstitution of IKATP: an inward rectifier subunit plus the sulfonylurea receptor

21 January 2018

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Defective insulin secretion and enhanced insulin action in KATP channel-deficient mice.

21 January 2018

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Sur1 knockout mice. A model for K(ATP) channel-independent regulation of insulin secretion

21 January 2018

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The C terminus of SUR1 is required for trafficking of KATP channels

21 January 2018

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Naturally occurring mutations in the human HNF4alpha gene impair the function of the transcription factor to a varying degree

21 January 2018

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Expression of transcription factor HNF-4 in the extraembryonic endoderm, gut, and nephrogenic tissue of the developing mouse embryo: HNF-4 is a marker for primary endoderm in the implanting blastocyst

21 January 2018

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Tissue-specific deletion of Foxa2 in pancreatic beta cells results in hyperinsulinemic hypoglycemia

21 January 2018

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Targeted Overactivity of β Cell KATP Channels Induces Profound Neonatal Diabetes

21 January 2018

1 reference

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Kir6.2 mutations are a common cause of permanent neonatal diabetes in a large cohort of French patients

21 January 2018

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Physiological and pathophysiological roles of ATP-sensitive K+ channels

21 January 2018

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Control of pancreas and liver gene expression by HNF transcription factors

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M507496200

21 January 2018

Identifiers

DOI

10.1074/JBC.M507496200

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26 December 2017

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26 December 2017