Rapamycin promotes vascular smooth muscle cell differentiation through insulin receptor substrate-1/phosphatidylinositol 3-kinase/Akt2 feedback signaling (Q46972339)

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scientific article published on 30 September 2007

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English	Rapamycin promotes vascular smooth muscle cell differentiation through insulin receptor substrate-1/phosphatidylinositol 3-kinase/Akt2 feedback signaling	scientific article published on 30 September 2007

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scholarly article

1 reference

Europe PubMed Central

PubMed publication ID

27 December 2017

http://europepmc.org/abstract/MED/17908691

Rapamycin promotes vascular smooth muscle cell differentiation through insulin receptor substrate-1/phosphatidylinositol 3-kinase/Akt2 feedback signaling (English)

1 reference

Europe PubMed Central

PubMed publication ID

27 December 2017

http://europepmc.org/abstract/MED/17908691

1 reference

based on heuristic

inferred from title

1 reference

based on heuristic

inferred from title

cell differentiation

1 reference

based on heuristic

inferred from title

author name string

Kathleen A Martin

1

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Europe PubMed Central

PubMed publication ID

27 December 2017

http://europepmc.org/abstract/MED/17908691

Bethany L Merenick

2

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Europe PubMed Central

PubMed publication ID

27 December 2017

http://europepmc.org/abstract/MED/17908691

Min Ding

3

1 reference

Europe PubMed Central

PubMed publication ID

27 December 2017

http://europepmc.org/abstract/MED/17908691

Kristina M Fetalvero

4

1 reference

Europe PubMed Central

PubMed publication ID

27 December 2017

http://europepmc.org/abstract/MED/17908691

Eva M Rzucidlo

5

1 reference

Europe PubMed Central

PubMed publication ID

27 December 2017

http://europepmc.org/abstract/MED/17908691

Courtney D Kozul

6

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Europe PubMed Central

PubMed publication ID

27 December 2017

http://europepmc.org/abstract/MED/17908691

David J Brown

7

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Europe PubMed Central

PubMed publication ID

27 December 2017

http://europepmc.org/abstract/MED/17908691

Helen Y Chiu

8

1 reference

Europe PubMed Central

PubMed publication ID

27 December 2017

http://europepmc.org/abstract/MED/17908691

Maureen Shyu

9

1 reference

Europe PubMed Central

PubMed publication ID

27 December 2017

http://europepmc.org/abstract/MED/17908691

Bethany L Drapeau

10

1 reference

Europe PubMed Central

PubMed publication ID

27 December 2017

http://europepmc.org/abstract/MED/17908691

Robert J Wagner

11

1 reference

Europe PubMed Central

PubMed publication ID

27 December 2017

http://europepmc.org/abstract/MED/17908691

Richard J Powell

12

1 reference

Europe PubMed Central

PubMed publication ID

27 December 2017

http://europepmc.org/abstract/MED/17908691

language of work or name

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publication date

30 September 2007

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Europe PubMed Central

PubMed publication ID

27 December 2017

http://europepmc.org/abstract/MED/17908691

Journal of Biological Chemistry

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Europe PubMed Central

PubMed publication ID

27 December 2017

http://europepmc.org/abstract/MED/17908691

282

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Europe PubMed Central

PubMed publication ID

27 December 2017

http://europepmc.org/abstract/MED/17908691

49

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Europe PubMed Central

PubMed publication ID

27 December 2017

http://europepmc.org/abstract/MED/17908691

36112-36120

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Europe PubMed Central

PubMed publication ID

27 December 2017

http://europepmc.org/abstract/MED/17908691

Molecular regulation of vascular smooth muscle cell differentiation in development and disease

1 reference

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Healing Achilles--sirolimus versus paclitaxel

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Review of randomized clinical trials of drug-eluting stents for the prevention of in-stent restenosis

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Safety and efficacy of sirolimus- and paclitaxel-eluting coronary stents.

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Rapamycin inhibits vascular smooth muscle cell migration

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Rapamycin-FKBP inhibits cell cycle regulators of proliferation in vascular smooth muscle cells

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The mTOR/p70 S6K1 pathway regulates vascular smooth muscle cell differentiation

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Coordinate regulation of translation by the PI 3-kinase and mTOR pathways

1 reference

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Growing roles for the mTOR pathway

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Restraining PI3K: mTOR signalling goes back to the membrane.

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Overactivation of S6 kinase 1 as a cause of human insulin resistance during increased amino acid availability.

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21 January 2018

Nutrient overload, insulin resistance, and ribosomal protein S6 kinase 1, S6K1.

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21 January 2018

Changes in the balance of phosphoinositide 3-kinase/protein kinase B (Akt) and the mitogen-activated protein kinases (ERK/p38MAPK) determine a phenotype of visceral and vascular smooth muscle cells

1 reference

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21 January 2018

Calcineurin-mediated pathway involved in the differentiated phenotype of smooth muscle cells

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M703914200

21 January 2018

Endothelial cell activation of the smooth muscle cell phosphoinositide 3-kinase/Akt pathway promotes differentiation

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M703914200

21 January 2018

Akt1/PKB upregulation leads to vascular smooth muscle cell hypertrophy and polyploidization.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M703914200

21 January 2018

Akt1/PKBalpha is required for normal growth but dispensable for maintenance of glucose homeostasis in mice

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M703914200

21 January 2018

Insulin resistance and a diabetes mellitus-like syndrome in mice lacking the protein kinase Akt2 (PKB beta)

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M703914200

21 January 2018

Distinct roles of Akt1 and Akt2 in regulating cell migration and epithelial-mesenchymal transition

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M703914200

21 January 2018

Amino acid and insulin signaling via the mTOR/p70 S6 kinase pathway. A negative feedback mechanism leading to insulin resistance in skeletal muscle cells

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M703914200

21 January 2018

The TSC1-2 tumor suppressor controls insulin-PI3K signaling via regulation of IRS proteins

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https://api.crossref.org/works/10.1074%2FJBC.M703914200

21 January 2018

A phosphatidylinositol 3-kinase/Akt/mTOR pathway mediates and PTEN antagonizes tumor necrosis factor inhibition of insulin signaling through insulin receptor substrate-1.

1 reference

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21 January 2018

Absence of S6K1 protects against age- and diet-induced obesity while enhancing insulin sensitivity

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M703914200

21 January 2018

Positive and negative regulatory role of insulin receptor substrate 1 and 2 (IRS-1 and IRS-2) serine/threonine phosphorylation.

1 reference

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21 January 2018

Protein kinase B alpha/Akt1 regulates placental development and fetal growth

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21 January 2018

Nutrients suppress phosphatidylinositol 3-kinase/Akt signaling via raptor-dependent mTOR-mediated insulin receptor substrate 1 phosphorylation

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M703914200

21 January 2018

PDGFRs are critical for PI3K/Akt activation and negatively regulated by mTOR

1 reference

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21 January 2018

Paclitaxel-eluting or sirolimus-eluting stents to prevent restenosis in diabetic patients

1 reference

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21 January 2018

Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M703914200

21 January 2018

Prolonged rapamycin treatment inhibits mTORC2 assembly and Akt/PKB

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M703914200

21 January 2018

Rapamycin inhibits cell motility by suppression of mTOR-mediated S6K1 and 4E-BP1 pathways

1 reference

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21 January 2018

Insulin receptor substrate-1/SHP-2 interaction, a phenotype-dependent switching machinery of insulin-like growth factor-I signaling in vascular smooth muscle cells

1 reference

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21 January 2018

Insulin increases the association of Akt-2 with Glut4-containing vesicles

1 reference

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21 January 2018

Isoform-specific regulation of insulin-dependent glucose uptake by Akt/protein kinase B.

1 reference

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Phenotypic modulation of smooth muscle cells through interaction of Foxo4 and myocardin

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21 January 2018

Identifiers

10.1074/JBC.M703914200

1 reference

Europe PubMed Central

PubMed publication ID

27 December 2017

http://europepmc.org/abstract/MED/17908691

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

27 December 2017

http://europepmc.org/abstract/MED/17908691

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