Ligand activation of peroxisome proliferator-activated receptor-beta/delta (PPARbeta/delta) and inhibition of cyclooxygenase 2 (COX2) attenuate colon carcinogenesis through independent signaling mechanisms. (Q46983610)

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scientific article published on 24 September 2007

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English	Ligand activation of peroxisome proliferator-activated receptor-beta/delta (PPARbeta/delta) and inhibition of cyclooxygenase 2 (COX2) attenuate colon carcinogenesis through independent signaling mechanisms.	scientific article published on 24 September 2007

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8 January 2020

Ligand activation of peroxisome proliferator-activated receptor-beta/delta (PPARbeta/delta) and inhibition of cyclooxygenase 2 (COX2) attenuate colon carcinogenesis through independent signaling mechanisms (English)

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8 January 2020

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8 January 2020

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Holly E Hollingshead

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8 January 2020

Michael G Borland

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Timothy M Willson

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Frank J Gonzalez

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24 September 2007

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8 January 2020

Up-regulation of cyclooxygenase 2 gene expression in human colorectal adenomas and adenocarcinomas

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21 January 2018

The role of cyclooxygenases in inflammation, cancer, and development

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Enhanced expression of cyclooxygenase (COX)-2 in human skin epidermal cancer cells: evidence for growth suppression by inhibiting COX-2 expression

1 reference

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21 January 2018

Inhibition of human colon cancer cell growth by selective inhibition of cyclooxygenase-2.

1 reference

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The effect of celecoxib, a cyclooxygenase-2 inhibitor, in familial adenomatous polyposis

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Regulation of the immune response by prostaglandins

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Prostaglandin E2 increases growth and motility of colorectal carcinoma cells

1 reference

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21 January 2018

Specific inhibition of cyclooxygenase 2 restores antitumor reactivity by altering the balance of IL-10 and IL-12 synthesis

1 reference

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21 January 2018

Prostaglandin E2 promotes colon cancer cell growth through a Gs-axin-beta-catenin signaling axis.

1 reference

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Phosphorylation of glycogen synthase kinase-3 and stimulation of T-cell factor signaling following activation of EP2 and EP4 prostanoid receptors by prostaglandin E2.

1 reference

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21 January 2018

Prostaglandin E2 Stimulates the beta-catenin/T cell factor-dependent transcription in colon cancer

1 reference

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21 January 2018

Colorectal cancer prevention and treatment by inhibition of cyclooxygenase-2.

1 reference

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21 January 2018

The role of cyclooxygenase inhibition in the antineoplastic effects of nonsteroidal antiinflammatory drugs (NSAIDs)

1 reference

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Inhibition of NF-kappaB and AP-1 activation by R- and S-flurbiprofen

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21 January 2018

PPARdelta activation induces COX-2 gene expression and cell proliferation in human hepatocellular carcinoma cells.

1 reference

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21 January 2018

Prostacyclin-mediated activation of peroxisome proliferator-activated receptor delta in colorectal cancer

1 reference

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21 January 2018

PPARdelta is an APC-regulated target of nonsteroidal anti-inflammatory drugs

1 reference

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21 January 2018

Prostaglandin E(2) promotes colorectal adenoma growth via transactivation of the nuclear peroxisome proliferator-activated receptor delta

1 reference

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21 January 2018

Cross-talk between peroxisome proliferator-activated receptor delta and cytosolic phospholipase A(2)alpha/cyclooxygenase-2/prostaglandin E(2) signaling pathways in human hepatocellular carcinoma cells

1 reference

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21 January 2018

A novel positive feedback loop between peroxisome proliferator-activated receptor-delta and prostaglandin E2 signaling pathways for human cholangiocarcinoma cell growth.

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2FBGM209

21 January 2018

Genetic disruption of PPARdelta decreases the tumorigenicity of human colon cancer cells

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2FBGM209

21 January 2018

Induction of PPARbeta and prostacyclin (PGI2) synthesis by Raf signaling: failure of PGI2 to activate PPARbeta.

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2FBGM209

21 January 2018

Inhibition of chemically induced skin carcinogenesis by sulindac is independent of peroxisome proliferator-activated receptor-beta/delta (PPARbeta/delta).

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2FBGM209

21 January 2018

PPARdelta status and Apc-mediated tumourigenesis in the mouse intestine

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2FBGM209

21 January 2018

Alteration of gene expression in normal-appearing colon mucosa of APC(min) mice and human cancer patients

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2FBGM209

21 January 2018

Ligand activation of peroxisome proliferator-activated receptor beta inhibits colon carcinogenesis.

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2FBGM209

21 January 2018

Peroxisome proliferator-activated receptor-delta attenuates colon carcinogenesis.

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2FBGM209

21 January 2018

Role of prostacyclin versus peroxisome proliferator-activated receptor beta receptors in prostacyclin sensing by lung fibroblasts

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2FBGM209

21 January 2018

Isoform specific changes in PPAR alpha and beta in colon and breast cancer with differentiation

1 reference

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21 January 2018

Ligand activation of peroxisome proliferator-activated receptor-beta/delta(PPARbeta/delta) inhibits cell growth of human N/TERT-1 keratinocytes

1 reference

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21 January 2018

Peroxisome proliferator-activated receptor delta as a molecular target to regulate lung cancer cell growth

1 reference

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21 January 2018

Peroxisome proliferator-activated receptor beta (delta)-dependent regulation of ubiquitin C expression contributes to attenuation of skin carcinogenesis.

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2FBGM209

21 January 2018

PPARbeta/delta selectively induces differentiation and inhibits cell proliferation

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2FBGM209

21 January 2018

Peroxisome proliferator-activated receptor-beta/delta inhibits epidermal cell proliferation by down-regulation of kinase activity

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2FBGM209

21 January 2018

Effects of di(2-ethylhexyl) phthalate, a widely used peroxisome proliferator and plasticizer, on cell growth in the human keratinocyte cell line NCTC 2544.

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2FBGM209

21 January 2018

Peroxisome proliferator-activated receptor expression and activation in normal human colonic epithelial cells and tubular adenomas

1 reference

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21 January 2018

Differentiation of trophoblast giant cells and their metabolic functions are dependent on peroxisome proliferator-activated receptor beta/delta

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21 January 2018

Indomethacin induces apoptosis in 786-O renal cell carcinoma cells by activating mitogen-activated protein kinases and AKT.

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21 January 2018

Growth, adipose, brain, and skin alterations resulting from targeted disruption of the mouse peroxisome proliferator-activated receptor beta(delta)

1 reference

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21 January 2018

Peroxisome proliferator-activated receptor beta/delta activation inhibits hypertrophy in neonatal rat cardiomyocytes

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21 January 2018

Peroxisome proliferator-activated receptor (PPAR)-beta/delta stimulates differentiation and lipid accumulation in keratinocytes

1 reference

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21 January 2018

Critical roles of PPAR beta/delta in keratinocyte response to inflammation

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21 January 2018

Modulation of keratinocyte gene expression and differentiation by PPAR-selective ligands and tetradecylthioacetic acid

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Activation of PPARdelta inhibits cardiac fibroblast proliferation and the transdifferentiation into myofibroblasts.

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PPARdelta modulates lipopolysaccharide-induced TNFalpha inflammation signaling in cultured cardiomyocytes.

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The PPARdelta agonist GW0742X reduces atherosclerosis in LDLR(-/-) mice

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PPARbeta/delta protects against experimental colitis through a ligand-independent mechanism.

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PPARalpha and PPARdelta activators inhibit cytokine-induced nuclear translocation of NF-kappaB and expression of VCAM-1 in EAhy926 endothelial cells

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PPARgamma and PPARdelta negatively regulate specific subsets of lipopolysaccharide and IFN-gamma target genes in macrophages

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ERK5 activation inhibits inflammatory responses via peroxisome proliferator-activated receptor delta (PPARdelta) stimulation.

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ER alpha-AHR-ARNT protein-protein interactions mediate estradiol-dependent transrepression of dioxin-inducible gene transcription

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PPARdelta is a very low-density lipoprotein sensor in macrophages

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Suppression of colitis-related mouse colon carcinogenesis by a COX-2 inhibitor and PPAR ligands

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The beta-catenin/TCF-4 complex imposes a crypt progenitor phenotype on colorectal cancer cells

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Crosstalk between peroxisome proliferator-activated receptor delta and VEGF stimulates cancer progression

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Angiopoietin-like 4 prevents metastasis through inhibition of vascular permeability and tumor cell motility and invasiveness

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21 January 2018

Peroxisome proliferator-activated receptor-beta/delta (PPARbeta/delta) ligands do not potentiate growth of human cancer cell lines

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Characteristics of the peroxisome proliferator activated receptor gamma (PPARgamma) ligand induced apoptosis in colon cancer cells

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Activation of peroxisome proliferator-activated receptor delta stimulates the proliferation of human breast and prostate cancer cell lines.

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21 January 2018

Genetic identification of Mom-1, a major modifier locus affecting Min-induced intestinal neoplasia in the mouse

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The Min (multiple intestinal neoplasia) mutation: its effect on gut epithelial cell differentiation and interaction with a modifier system

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Identification of the modifier of Min 2 (Mom2) locus, a new mutation that influences Apc-induced intestinal neoplasia.

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21 January 2018

Activation of nuclear hormone receptor peroxisome proliferator-activated receptor-delta accelerates intestinal adenoma growth

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The role of peroxisome proliferator-activated receptor-beta/delta in epithelial cell growth and differentiation

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21 January 2018

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