Intracellular trafficking of TREM2 is regulated by presenilin 1. (Q47151761)

9 January 2018

title

Intracellular trafficking of TREM2 is regulated by presenilin 1. (English)

1 reference

9 January 2018

author name string

Yingjun Zhao

1

1 reference

9 January 2018

Xiaoguang Li

2

1 reference

9 January 2018

Timothy Huang

3

1 reference

9 January 2018

Zhenqiu Tan

5

1 reference

9 January 2018

Muxian Zhang

6

1 reference

9 January 2018

Irene Han-Juo Cheng

7

1 reference

9 January 2018

Xin Wang

8

1 reference

9 January 2018

Guojun Bu

9

1 reference

9 January 2018

Qi Wang

11

1 reference

9 January 2018

Huaxi Xu

12

1 reference

9 January 2018

Lu-Lin Jiang

4

1 reference

29 April 2018

Yun-Wu Zhang

10

1 reference

29 April 2018

publication date

1 December 2017

1 reference

9 January 2018

Experimental and Molecular Medicine

published in

1 reference

9 January 2018

volume

49

1 reference

9 January 2018

issue

12

1 reference

9 January 2018

page(s)

e405

1 reference

29 April 2018

Creative Commons Attribution 4.0 International

copyright license

start time

1 December 2017

1 reference

April 2022 Public Data File from Crossref

copyright status

copyrighted

0 references

exact match

https://scigraph.springernature.com/pub.10.1038/emm.2017.200

0 references

cites work

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TREM2 Binds to Apolipoproteins, Including APOE and CLU/APOJ, and Thereby Facilitates Uptake of Amyloid-Beta by Microglia.

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Functional involvement of γ-secretase in signaling of the triggering receptor expressed on myeloid cells-2 (TREM2).

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Apolipoprotein E Is a Ligand for Triggering Receptor Expressed on Myeloid Cells 2 (TREM2).

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R47H Variant of TREM2 Associated With Alzheimer Disease in a Large Late-Onset Family: Clinical, Genetic, and Neuropathological Study

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DAP12 Stabilizes the C-terminal Fragment of the Triggering Receptor Expressed on Myeloid Cells-2 (TREM2) and Protects against LPS-induced Pro-inflammatory Response

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TREM2 lipid sensing sustains the microglial response in an Alzheimer's disease model

23 May 2018

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Triggering receptor expressed on myeloid cells 2 (TREM2) deficiency attenuates phagocytic activities of microglia and exacerbates ischemic damage in experimental stroke.

23 May 2018

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TREM2 variant p.R47H as a risk factor for sporadic amyotrophic lateral sclerosis

23 May 2018

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Heterozygous TREM2 mutations in frontotemporal dementia

23 May 2018

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Sequential proteolytic processing of the triggering receptor expressed on myeloid cells-2 (TREM2) protein by ectodomain shedding and γ-secretase-dependent intramembranous cleavage

23 May 2018

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Insights into TREM2 biology by network analysis of human brain gene expression data

23 May 2018

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TREM2 in neurodegeneration: evidence for association of the p.R47H variant with frontotemporal dementia and Parkinson's disease

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Using exome sequencing to reveal mutations in TREM2 presenting as a frontotemporal dementia-like syndrome without bone involvement

23 May 2018

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23 May 2018

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Role of presenilins in neuronal calcium homeostasis

23 May 2018

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Lysosomal proteolysis and autophagy require presenilin 1 and are disrupted by Alzheimer-related PS1 mutations

23 May 2018

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Mechanisms underlying inflammation in neurodegeneration

23 May 2018

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A role for TREM2 ligands in the phagocytosis of apoptotic neuronal cells by microglia

23 May 2018

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SERCA pump activity is physiologically regulated by presenilin and regulates amyloid beta production

23 May 2018

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Pathological and physiological functions of presenilins

23 May 2018

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Clearance of apoptotic neurons without inflammation by microglial triggering receptor expressed on myeloid cells-2.

23 May 2018

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Distribution and signaling of TREM2/DAP12, the receptor system mutated in human polycystic lipomembraneous osteodysplasia with sclerosing leukoencephalopathy dementia

23 May 2018

1 reference

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TREMs in the immune system and beyond

23 May 2018

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γ-Secretase is a membrane protein complex comprised of presenilin, nicastrin, aph-1, and pen-2

23 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5750471

Aph-1, Pen-2, and Nicastrin with Presenilin generate an active gamma-Secretase complex

23 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5750471

Heterogeneous expression of the triggering receptor expressed on myeloid cells-2 on adult murine microglia

23 May 2018

1 reference

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A DAP12-mediated pathway regulates expression of CC chemokine receptor 7 and maturation of human dendritic cells

23 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5750471

Two transmembrane aspartates in presenilin-1 required for presenilin endoproteolysis and gamma-secretase activity

23 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5750471

Endoproteolysis of presenilin 1 and accumulation of processed derivatives in vivo

23 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5750471

Alzheimer's disease: Initial report of the purification and characterization of a novel cerebrovascular amyloid protein

23 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5750471

Disease-Associated Mutations of TREM2 Alter the Processing of N-Linked Oligosaccharides in the Golgi Apparatus.

23 May 2018

1 reference

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Investigating the role of rare heterozygous TREM2 variants in Alzheimer's disease and frontotemporal dementia.

15 August 2018

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Variant TREM2 as risk factor for Alzheimer's disease

15 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5750471

Effects of PS1 deficiency on membrane protein trafficking in neurons.

15 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5750471

Presenilin-1 regulates intracellular trafficking and cell surface delivery of beta-amyloid precursor protein

15 August 2018

1 reference

Crossref

https://api.crossref.org/works/10.1038%2FEMM.2017.200

inferred from DOI database lookup

7 January 2021

based on heuristic

Identifiers

DOI

10.1038/EMM.2017.200

1 reference

29 April 2018

PMCID

5750471

1 reference

9 January 2018

PubMed ID

29611543

1 reference

29 April 2018