Presenilin-1 regulates intracellular trafficking and cell surface delivery of beta-amyloid precursor protein (Q78525357)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12435726%20AND%20SRC:MED&resulttype=core&format=json

15 December 2019

title

Presenilin-1 regulates intracellular trafficking and cell surface delivery of beta-amyloid precursor protein (English)

1 reference

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15 December 2019

10

Paul Greengard

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15 December 2019

author name string

Dongming Cai

1

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15 December 2019

Jae Yoon Leem

2

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15 December 2019

Jeffrey P Greenfield

3

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15 December 2019

Pei Wang

4

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15 December 2019

Benny S Kim

5

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15 December 2019

Runsheng Wang

6

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15 December 2019

Kryslaine O Lopes

7

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15 December 2019

Seong-Hun Kim

8

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15 December 2019

Hui Zheng

9

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15 December 2019

Sangram S Sisodia

11

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15 December 2019

Gopal Thinakaran

12

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15 December 2019

Huaxi Xu

13

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15 December 2019

language of work or name

English

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publication date

14 November 2002

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Journal of Biological Chemistry

15 December 2019

published in

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15 December 2019

volume

278

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15 December 2019

issue

5

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15 December 2019

page(s)

3446-3454

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Presenilin 1 is required for Notch1 and DII1 expression in the paraxial mesoderm

15 December 2019

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Nicastrin modulates presenilin-mediated notch/glp-1 signal transduction and betaAPP processing

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Presenilins are not required for A beta 42 production in the early secretory pathway.

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Cellular and molecular basis of beta-amyloid precursor protein metabolism

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Familial Alzheimer's disease-linked presenilin 1 variants elevate Abeta1-42/1-40 ratio in vitro and in vivo

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Precursor of amyloid protein in Alzheimer disease undergoes fast anterograde axonal transport

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Generation of Alzheimer beta-amyloid protein in the trans-Golgi network in the apparent absence of vesicle formation

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Transport of vesicular stomatitis virus G protein to the cell surface is signal mediated in polarized and nonpolarized cells

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Secreted amyloid beta-protein similar to that in the senile plaques of Alzheimer's disease is increased in vivo by the presenilin 1 and 2 and APP mutations linked to familial Alzheimer's disease

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Alzheimer's presenilin 1 is a putative membrane receptor for rab GDP dissociation inhibitor

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Deficiency of presenilin-1 inhibits the normal cleavage of amyloid precursor protein

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Interaction with telencephalin and the amyloid precursor protein predicts a ring structure for presenilins

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Endoplasmic reticulum and trans-Golgi network generate distinct populations of Alzheimer beta-amyloid peptides

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Multiple effects of aspartate mutant presenilin 1 on the processing and trafficking of amyloid precursor protein

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Alzheimer amyloid protein precursor in the rat hippocampus: transport and processing through the perforant path

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Two transmembrane aspartates in presenilin-1 required for presenilin endoproteolysis and gamma-secretase activity

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Morphologic and biochemical analysis of the intracellular trafficking of the Alzheimer beta/A4 amyloid precursor protein.

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Expression of beta-amyloid precursor protein-CD3gamma chimeras to demonstrate the selective generation of amyloid beta(1-40) and amyloid beta(1-42) peptides within secretory and endocytic compartments

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Photoactivated gamma-secretase inhibitors directed to the active site covalently label presenilin 1

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Presenilin-1 affects trafficking and processing of betaAPP and is targeted in a complex with nicastrin to the plasma membrane

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Presenilin and nicastrin regulate each other and determine amyloid beta-peptide production via complex formation

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Mutant human presenilin 1 protects presenilin 1 null mouse against embryonic lethality and elevates Abeta1-42/43 expression.

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A role for presenilin 1 in regulating the delivery of amyloid precursor protein to the cell surface

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Carboxyl-terminal fragments of Alzheimer beta-amyloid precursor protein accumulate in restricted and unpredicted intracellular compartments in presenilin 1-deficient cells.

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12 October 2022

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The cell biology of beta-amyloid precursor protein and presenilin in Alzheimer's disease

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Function and dysfunction of the presenilins

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Presenilin is required for activity and nuclear access of Notch in Drosophila

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12 October 2022

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Presenilins interact with Rab11, a small GTPase involved in the regulation of vesicular transport

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12 October 2022

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gamma-Secretase, Notch, Abeta and Alzheimer's disease: where do the presenilins fit in?

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12 October 2022

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Kinesin-mediated axonal transport of a membrane compartment containing beta-secretase and presenilin-1 requires APP

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12 October 2022

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APH-1 is a multipass membrane protein essential for the Notch signaling pathway in Caenorhabditis elegans embryos

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12 October 2022

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Presenilin 1 is linked with gamma-secretase activity in the detergent solubilized state

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12 October 2022

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Presenilin, Notch, and the genesis and treatment of Alzheimer's disease

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Lack of requirement for presenilin1 in Notch1 signaling.

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12 October 2022

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Axonal transport of amyloid precursor protein is mediated by direct binding to the kinesin light chain subunit of kinesin-I

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12 October 2022

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The transmembrane domain of the Alzheimer's beta-secretase (BACE1) determines its late Golgi localization and access to beta -amyloid precursor protein (APP) substrate

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12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1074/JBC.M209065200

The use of permeabilized cells to investigate secretory granule biogenesis.

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12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1074/JBC.M209065200

Identifiers

DOI

10.1074/JBC.M209065200

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12435726%20AND%20SRC:MED&resulttype=core&format=json

15 December 2019

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