Sterol methyltransferase a target for anti-amoeba therapy: towards transition state analog and suicide substrate drug design. (Q47162328)

10 January 2018

title

Sterol methyltransferase a target for anti-amoeba therapy: towards transition state analog and suicide substrate drug design. (English)

1 reference

10 January 2018

author name string

Medhanie E Kidane

1

1 reference

10 January 2018

Boden H Vanderloop

2

1 reference

10 January 2018

Wenxu Zhou

3

1 reference

10 January 2018

Crista D Thomas

4

1 reference

10 January 2018

Emilio Ramos

5

1 reference

10 January 2018

Ujjal Singha

6

1 reference

10 January 2018

Minu Chaudhuri

7

1 reference

10 January 2018

W David Nes

8

1 reference

10 January 2018

publication date

17 October 2017

1 reference

10 January 2018

Journal of Lipid Research

published in

1 reference

10 January 2018

volume

58

1 reference

10 January 2018

page(s)

2310-2323

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10 January 2018

issue

12

1 reference

10 January 2018

24-Methylenecyclopropane steroidal inhibitors: A Trojan horse in ergosterol biosynthesis that prevents growth of Trypanosoma brucei

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Characterization, mutagenesis and mechanistic analysis of an ancient algal sterol C24-methyltransferase: Implications for understanding sterol evolution in the green lineage

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Motility and more: the flagellum of Trypanosoma brucei

23 May 2018

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Genome profiling of sterol synthesis shows convergent evolution in parasites and guides chemotherapeutic attack

23 May 2018

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Cloning, mechanistic and functional analysis of a fungal sterol C24-methyltransferase implicated in brassicasterol biosynthesis

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Sterol Biosynthesis Pathway as Target for Anti-trypanosomatid Drugs

23 May 2018

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Successful treatment of disseminated Acanthamoeba sp. infection with miltefosine

23 May 2018

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Photoaffinity labeling and mutational analysis of 24-C-sterol methyltransferase defines the AdoMet binding site

23 May 2018

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Biosynthesis and accumulation of sterols

23 May 2018

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Acanthamoebaspp. as Agents of Disease in Humans

23 May 2018

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Active site mapping and substrate channeling in the sterol methyltransferase pathway

23 May 2018

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Sterol phylogenesis and algal evolution

23 May 2018

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Mechanism and structural requirements for transformation of substrates by the (S)-adenosyl-L-methionine:delta 24(25)-sterol methyl transferase from Saccharomyces cerevisiae

23 May 2018

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Sterol biosynthesis de nova via cycloartenol by the soil amoeba Acanthamoeba polyphaga

23 May 2018

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The action of the systemic fungicides tridemorph and fenpropimorph on sterol biosynthesis by the soil amoeba Acanthamoeba polyphaga

23 May 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5711494

Sterols of Acanthamoeba culbertsoni strain A-1.

23 May 2018

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Molecular probing of the Saccharomyces cerevisiae sterol 24-C methyltransferase reveals multiple amino acid residues involved with C2-transfer activity

23 May 2018

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Mechanistic analysis of a multiple product sterol methyltransferase implicated in ergosterol biosynthesis in Trypanosoma brucei

15 August 2018

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15 August 2018

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Biosynthesis of phytosterols. Kinetic mechanism for the enzymatic C-methylation of sterols

15 August 2018

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Isolation and characterization of an active-site peptide from a sterol methyl transferase with a mechanism-based inhibitor.

15 August 2018

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Mechanism and structural requirements for transformation of substrates by the methyl transferase from Saccharomyces cerevisiae

15 August 2018

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Crossref

https://api.crossref.org/works/10.1194%2FJLR.M079418

Antiproliferative effects of delta 24(25) sterol methyl transferase inhibitors on Trypanosoma (Schizotrypanum) cruzi: in vitro and in vivo studies

21 January 2018

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7-Dehydrostigmasterol and ergosterol: the major sterols of an amoeba

1 December 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/29042405

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Modification of the sterol composition of Trypanosoma (Schizotrypanum) cruzi epimastigotes by delta 24(25)-sterol methyl transferase inhibitors and their combinations with ketoconazole

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/29042405

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Regulation of sterol biosynthesis in sunflower by 24(R,S),25-epiminolanosterol, a novel C-24 methyl transferase inhibitor

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/29042405

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1194/JLR.M079418

1 reference

10 January 2018

PMCID

5711494

1 reference

10 January 2018

PubMed ID

29042405

1 reference

10 January 2018