The methyltransferase NSD3 promotes antiviral innate immunity via direct lysine methylation of IRF3. (Q47443018)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29101251%20AND%20SRC:MED&resulttype=core&format=json

8 April 2020

title

The methyltransferase NSD3 promotes antiviral innate immunity via direct lysine methylation of IRF3 (English)

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8 April 2020

6

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8 April 2020

Xuetao Cao

7

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8 April 2020

author name string

Chunmei Wang

1

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8 April 2020

Qinlan Wang

2

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8 April 2020

Xiaoqing Xu

3

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8 April 2020

Bin Xie

4

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8 April 2020

Yong Zhao

5

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8 April 2020

language of work or name

English

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publication date

3 November 2017

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Journal of Experimental Medicine

8 April 2020

published in

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8 April 2020

volume

214

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8 April 2020

issue

12

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8 April 2020

page(s)

3597-3610

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Methyltransferase SETD2-Mediated Methylation of STAT1 Is Critical for Interferon Antiviral Activity

8 April 2020

cites work

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SMYD3-mediated lysine methylation in the PH domain is critical for activation of AKT1.

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Post-Translational Modification Control of Innate Immunity

27 July 2018

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Methyltransferase Dnmt3a upregulates HDAC9 to deacetylate the kinase TBK1 for activation of antiviral innate immunity

27 July 2018

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Tet2 is required to resolve inflammation by recruiting Hdac2 to specifically repress IL-6

27 July 2018

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The NSD family of protein methyltransferases in human cancer

27 July 2018

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The Methyltransferase NSD3 Has Chromatin-binding Motifs, PHD5-C5HCH, That Are Distinct from Other NSD (Nuclear Receptor SET Domain) Family Members in Their Histone H3 Recognition

27 July 2018

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The histone methyltransferase Wolf-Hirschhorn syndrome candidate 1-like 1 (WHSC1L1) is involved in human carcinogenesis

27 July 2018

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The histone methyltransferase MMSET/WHSC1 activates TWIST1 to promote an epithelial-mesenchymal transition and invasive properties of prostate cancer

27 July 2018

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Histone methyltransferase NSD2/MMSET mediates constitutive NF-κB signaling for cancer cell proliferation, survival, and tumor growth via a feed-forward loop

27 July 2018

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Histone lysine methyltransferase Wolf-Hirschhorn syndrome candidate 1 is involved in human carcinogenesis through regulation of the Wnt pathway

27 July 2018

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Structural basis of SETD6-mediated regulation of the NF-kB network via methyl-lysine signaling

27 July 2018

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Lysine methylation of the NF-κB subunit RelA by SETD6 couples activity of the histone methyltransferase GLP at chromatin to tonic repression of NF-κB signaling

27 July 2018

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Interplay between lysine methylation and Cdk phosphorylation in growth control by the retinoblastoma protein

27 July 2018

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A cryptic sensor for HIV-1 activates antiviral innate immunity in dendritic cells

27 July 2018

1 reference

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Regulation of NF-kappaB by NSD1/FBXL11-dependent reversible lysine methylation of p65.

27 July 2018

1 reference

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Identification of gene biomarkers for respiratory syncytial virus infection in a bronchial epithelial cell line

27 July 2018

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Innate immunity to virus infection.

27 July 2018

1 reference

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Negative feedback regulation of cellular antiviral signaling by RBCK1-mediated degradation of IRF3

27 July 2018

1 reference

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Interferon-inducible antiviral effectors

27 July 2018

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S-glutathionylation of IRF3 regulates IRF3-CBP interaction and activation of the IFN beta pathway

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5716042

Methylation of proteins involved in translation

27 July 2018

1 reference

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Regulation of p53 activity through lysine methylation

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5716042

IKKepsilon and TBK1 are essential components of the IRF3 signaling pathway

27 July 2018

1 reference

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MxA Mediates SUMO-Induced Resistance to Vesicular Stomatitis Virus.

27 July 2018

1 reference

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The tumor suppressor PTEN has a critical role in antiviral innate immunity

14 August 2018

1 reference

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MAPK phosphatase 5 inhibits IRF3.

14 August 2018

1 reference

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STAT3-driven transcription depends upon the dimethylation of K49 by EZH2.

14 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5716042

The methyltransferase Ezh2 controls cell adhesion and migration through direct methylation of the extranuclear regulatory protein talin

14 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5716042

Critical roles of non-histone protein lysine methylation in human tumorigenesis

14 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5716042

Non-histone protein methylation as a regulator of cellular signalling and function

14 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5716042

Protein phosphatase PP1 negatively regulates the Toll-like receptor- and RIG-I-like receptor-triggered production of type I interferon by inhibiting IRF3 phosphorylation at serines 396 and 385 in macrophage.

14 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5716042

Unconventional post-translational modifications in immunological signaling

14 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5716042

Recruitment of phosphatase PP2A by RACK1 adaptor protein deactivates transcription factor IRF3 and limits type I interferon signaling.

14 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5716042

An H3K9/S10 methyl-phospho switch modulates Polycomb and Pol II binding at repressed genes during differentiation

14 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5716042

Hepatic RIG-I predicts survival and interferon-α therapeutic response in hepatocellular carcinoma

14 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5716042

Zinc finger protein 64 promotes Toll-like receptor-triggered proinflammatory and type I interferon production in macrophages by enhancing p65 subunit activation

14 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5716042

Phosphorylation of EZH2 activates STAT3 signaling via STAT3 methylation and promotes tumorigenicity of glioblastoma stem-like cells

14 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5716042

The Brd4 extraterminal domain confers transcription activation independent of pTEFb by recruiting multiple proteins, including NSD3.

14 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5716042

The ubiquitin E3 ligase RAUL negatively regulates type i interferon through ubiquitination of the transcription factors IRF7 and IRF3.

14 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5716042

Post-translational modifications in signal integration

14 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5716042

Regulation of NF-kappaB activity through lysine monomethylation of p65.

14 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5716042

Arginine methylation of FOXO transcription factors inhibits their phosphorylation by Akt.

14 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5716042

Phosphatase SHP-1 promotes TLR- and RIG-I-activated production of type I interferon by inhibiting the kinase IRAK1.

14 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5716042

NUP98-NSD1 links H3K36 methylation to Hox-A gene activation and leukaemogenesis.

14 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5716042

SHP-2 phosphatase negatively regulates the TRIF adaptor protein-dependent type I interferon and proinflammatory cytokine production

14 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5716042

Negative regulation of interferon-regulatory factor 3-dependent innate antiviral response by the prolyl isomerase Pin1.

14 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5716042

Direct involvement of CREB-binding protein/p300 in sequence-specific DNA binding of virus-activated interferon regulatory factor-3 holocomplex

14 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5716042

14 August 2018

Identifiers

DOI

10.1084/JEM.20170856

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29101251%20AND%20SRC:MED&resulttype=core&format=json

8 April 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29101251%20AND%20SRC:MED&resulttype=core&format=json

8 April 2020

PubMed publication ID

29101251

1 reference