Unconventional post-translational modifications in immunological signaling (Q38212817)

31 August 2017

Unconventional post-translational modifications in immunological signaling (English)

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31 August 2017

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Kerri A Mowen

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PubMed ID

24840982

31 August 2017

Michael David

series ordinal

2

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PubMed ID

24840982

31 August 2017

language of work or name

English

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publication date

1 June 2014

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31 August 2017

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31 August 2017

15

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31 August 2017

512-520

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31 August 2017

6

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Toll-like receptors and their crosstalk with other innate receptors in infection and immunity

31 August 2017

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Crosstalk in NF-κB signaling pathways

21 January 2018

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JAK and STAT signaling molecules in immunoregulation and immune-mediated disease

21 January 2018

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NFAT, immunity and cancer: a transcription factor comes of age.

21 January 2018

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Histone lysine methylation dynamics: establishment, regulation, and biological impact

21 January 2018

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The diverse functions of histone lysine methylation

21 January 2018

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Chromatin topology and the regulation of antigen receptor assembly

21 January 2018

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Transcriptional and epigenetic control of T helper cell specification: molecular mechanisms underlying commitment and plasticity.

21 January 2018

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Maintaining cell identity through global control of genomic organization

21 January 2018

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Epigenetics of haematopoietic cell development

21 January 2018

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Arginine methylation at a glance

21 January 2018

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Human protein arginine methyltransferase 7 (PRMT7) is a type III enzyme forming ω-NG-monomethylated arginine residues.

21 January 2018

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Arginine methylation inhibits the binding of proline-rich ligands to Src homology 3, but not WW, domains

21 January 2018

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Lysine methylation of the NF-κB subunit RelA by SETD6 couples activity of the histone methyltransferase GLP at chromatin to tonic repression of NF-κB signaling

21 January 2018

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Regulation of NF-kappaB activity through lysine monomethylation of p65.

21 January 2018

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Regulation of NF-kappaB by NSD1/FBXL11-dependent reversible lysine methylation of p65.

21 January 2018

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Role of lysine methylation of NF-κB in differential gene regulation

21 January 2018

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Reversible methylation of promoter-bound STAT3 by histone-modifying enzymes

21 January 2018

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CD28 costimulatory signal induces protein arginine methylation in T cells.

21 January 2018

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NIP45 controls the magnitude of the type 2 T helper cell response.

21 January 2018

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Arginine methylation of NIP45 modulates cytokine gene expression in effector T lymphocytes

21 January 2018

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Arginine methylation of the B cell antigen receptor promotes differentiation.

21 January 2018

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The JAK-STAT pathway at twenty

21 January 2018

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A protein-arginine methyltransferase binds to the intracytoplasmic domain of the IFNAR1 chain in the type I interferon receptor

21 January 2018

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Identification of JAK/STAT signalling components by genome-wide RNA interference.

21 January 2018

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The human homologue of the yeast proteins Skb1 and Hsl7p interacts with Jak kinases and contains protein methyltransferase activity

21 January 2018

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Arginine methylation of STAT1 modulates IFNalpha/beta-induced transcription

21 January 2018

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Are STATS arginine-methylated?

21 January 2018

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The arginine-1493 residue in QRRGRTGR1493G motif IV of the hepatitis C virus NS3 helicase domain is essential for NS3 protein methylation by the protein arginine methyltransferase 1.

21 January 2018

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Methylation of STAT6 modulates STAT6 phosphorylation, nuclear translocation, and DNA-binding activity

21 January 2018

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Disruption of protein arginine N-methyltransferase 2 regulates leptin signaling and produces leanness in vivo through loss of STAT3 methylation

21 January 2018

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Hepatitis C virus inhibits interferon signaling through up-regulation of protein phosphatase 2A.

21 January 2018

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Regulation of transcription by a protein methyltransferase

21 January 2018

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Minireview: protein arginine methylation of nonhistone proteins in transcriptional regulation

21 January 2018

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Arginine methyltransferase CARM1 is a promoter-specific regulator of NF-kappaB-dependent gene expression

21 January 2018

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Post-transcriptional regulons coordinate the initiation and resolution of inflammation

21 January 2018

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Lipopolysaccharide-induced methylation of HuR, an mRNA-stabilizing protein, by CARM1. Coactivator-associated arginine methyltransferase

21 January 2018

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Specific protein methylation defects and gene expression perturbations in coactivator-associated arginine methyltransferase 1-deficient mice

21 January 2018

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Coactivator-associated arginine methyltransferase 1 regulates fetal hematopoiesis and thymocyte development

21 January 2018

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NSD2 links dimethylation of histone H3 at lysine 36 to oncogenic programming

21 January 2018

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The MMSET histone methyl transferase switches global histone methylation and alters gene expression in t(4;14) multiple myeloma cells.

21 January 2018

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EZH2 inhibition as a therapeutic strategy for lymphoma with EZH2-activating mutations

21 January 2018

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Protein arginine methyltransferase 5 (PRMT5) inhibition induces lymphoma cell death through reactivation of the retinoblastoma tumor suppressor pathway and polycomb repressor complex 2 (PRC2) silencing.

21 January 2018

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Low levels of miR-92b/96 induce PRMT5 translation and H3R8/H4R3 methylation in mantle cell lymphoma

21 January 2018

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Protein arginine methyltransferase 5 suppresses the transcription of the RB family of tumor suppressors in leukemia and lymphoma cells

21 January 2018

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JAK2V617F-mediated phosphorylation of PRMT5 downregulates its methyltransferase activity and promotes myeloproliferation

21 January 2018

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Chromatin proteins and modifications as drug targets

21 January 2018

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Protein arginine-methyltransferase-dependent oncogenesis

21 January 2018

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CARM1 is required for proper control of proliferation and differentiation of pulmonary epithelial cells

21 January 2018

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PAD, a growing family of citrullinating enzymes: genes, features and involvement in disease

21 January 2018

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Citrullination: a posttranslational modification in health and disease

21 January 2018

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Update on peptidylarginine deiminases and deimination in skin physiology and severe human diseases.

21 January 2018

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Structural basis for Ca(2+)-induced activation of human PAD4

21 January 2018

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Comparison of enzymatic properties between hPADI2 and hPADI4

21 January 2018

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Peptidyl arginine deiminase type 2 (PAD-2) and PAD-4 but not PAD-1, PAD-3, and PAD-6 are expressed in rheumatoid arthritis synovium in close association with tissue inflammation

21 January 2018

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ATP induces protein arginine deiminase 2-dependent citrullination in mast cells through the P2X7 purinergic receptor

21 January 2018

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Peptidylarginine deiminase 2 suppresses inhibitory {kappa}B kinase activity in lipopolysaccharide-stimulated RAW 264.7 macrophages

21 January 2018

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Integrating cell-signalling pathways with NF-kappaB and IKK function

21 January 2018

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How dying cells alert the immune system to danger

21 January 2018

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ATP drives lamina propria T(H)17 cell differentiation

21 January 2018

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The role of the purinergic P2X7 receptor in inflammation

21 January 2018

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Antimicrobial mechanisms of phagocytes and bacterial evasion strategies

21 January 2018

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How human neutrophils kill and degrade microbes: an integrated view

21 January 2018

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Neutrophil extracellular traps kill bacteria

21 January 2018

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PAD4-mediated neutrophil extracellular trap formation is not required for immunity against influenza infection

21 January 2018

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PAD4 is essential for antibacterial innate immunity mediated by neutrophil extracellular traps

21 January 2018

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Histone hypercitrullination mediates chromatin decondensation and neutrophil extracellular trap formation.

21 January 2018

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T-bet deficiency reduces atherosclerosis and alters plaque antigen-specific immune responses

21 January 2018

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Immunity to citrullinated proteins in rheumatoid arthritis

21 January 2018

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Translational mini-review series on Th17 cells: function and regulation of human T helper 17 cells in health and disease.

21 January 2018

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Epitope spreading to citrullinated antigens in mouse models of autoimmune arthritis and demyelination.

21 January 2018

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Myelin localization of peptidylarginine deiminases 2 and 4: comparison of PAD2 and PAD4 activities

21 January 2018

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Peptidylarginine deiminase: a candidate factor in demyelinating disease

21 January 2018

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Increased and type II-specific expression of peptidylarginine deiminase in activated microglia but not hyperplastic astrocytes following kainic acid-evoked neurodegeneration in the rat brain

21 January 2018

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Increased peptidylarginine deiminase type II in hypoxic astrocytes

21 January 2018

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Peptidylarginine deiminase 2 (PAD2) overexpression in transgenic mice leads to myelin loss in the central nervous system

21 January 2018

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The major synovial targets of the rheumatoid arthritis-specific antifilaggrin autoantibodies are deiminated forms of the alpha- and beta-chains of fibrin

21 January 2018

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Arthritis induced by posttranslationally modified (citrullinated) fibrinogen in DR4-IE transgenic mice

21 January 2018

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Antibodies against citrullinated proteins enhance tissue injury in experimental autoimmune arthritis

21 January 2018

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Citrullinated proteins have increased immunogenicity and arthritogenicity and their presence in arthritic joints correlates with disease severity

21 January 2018

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Functional haplotypes of PADI4, encoding citrullinating enzyme peptidylarginine deiminase 4, are associated with rheumatoid arthritis

21 January 2018

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High-density genetic mapping identifies new susceptibility loci for rheumatoid arthritis

21 January 2018

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Circulating immune complexes contain citrullinated fibrinogen in rheumatoid arthritis

21 January 2018

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Felty's syndrome autoantibodies bind to deiminated histones and neutrophil extracellular chromatin traps

21 January 2018

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Isoforms of nitric oxide synthase Characterization and purification from different cell types

21 January 2018

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Molecular basis of NMDA receptor-coupled ion channel modulation by S-nitrosylation

21 January 2018

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S-nitrosylated protein-disulphide isomerase links protein misfolding to neurodegeneration

21 January 2018

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Structural profiling of endogenous S-nitrosocysteine residues reveals unique features that accommodate diverse mechanisms for protein S-nitrosylation.

21 January 2018

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Ubiquitin protein ligase activity of IAPs and their degradation in proteasomes in response to apoptotic stimuli

21 January 2018

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Transnitrosylation of XIAP regulates caspase-dependent neuronal cell death

21 January 2018

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S-nitrosylated GAPDH initiates apoptotic cell death by nuclear translocation following Siah1 binding

21 January 2018

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Denitrosylation of S-nitrosylated OGT is triggered in LPS-stimulated innate immune response

21 January 2018

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The SNO-proteome: causation and classifications

21 January 2018

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Cyclosporine A-induced nitration of tyrosine 34 MnSOD in endothelial cells: role of mitochondrial superoxide

21 January 2018

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Impaired response to interferon-gamma in activated macrophages due to tyrosine nitration of STAT1 by endogenous nitric oxide

21 January 2018

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Cutting edge: MHC class II-restricted peptides containing the inflammation-associated marker 3-nitrotyrosine evade central tolerance and elicit a robust cell-mediated immune response

21 January 2018

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Activated antigen-presenting cells select and present chemically modified peptides recognized by unique CD4 T cells

21 January 2018

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Altered recognition of antigen is a mechanism of CD8+ T cell tolerance in cancer

21 January 2018

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Chromatin modifications and their function

21 January 2018

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The many roles of histone deacetylases in development and physiology: implications for disease and therapy

21 January 2018

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Acetylation of MKP-1 and the control of inflammation.

21 January 2018

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Induction of interferon-stimulated gene expression and antiviral responses require protein deacetylase activity.

21 January 2018

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Acetylation of HMG I(Y) by CBP turns off IFN beta expression by disrupting the enhanceosome

21 January 2018

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Acetylation of RelA at discrete sites regulates distinct nuclear functions of NF-kappaB.

21 January 2018

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Interferon-stimulated transcription and innate antiviral immunity require deacetylase activity and histone deacetylase 1.

21 January 2018

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Acetylation of Stat1 modulates NF-kappaB activity

21 January 2018

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Activation of Stat3 sequence-specific DNA binding and transcription by p300/CREB-binding protein-mediated acetylation

21 January 2018

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Stat3 dimerization regulated by reversible acetylation of a single lysine residue

21 January 2018

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GATA switches as developmental drivers

21 January 2018

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Distinct functions for the transcription factor Foxo1 at various stages of B cell differentiation

21 January 2018

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Foxo1 links homing and survival of naive T cells by regulating L-selectin, CCR7 and interleukin 7 receptor.

21 January 2018

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Foxo transcription factors control regulatory T cell development and function

21 January 2018

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Functional regulation of GATA-2 by acetylation

21 January 2018

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Acetylation of GATA-3 affects T-cell survival and homing to secondary lymphoid organs

21 January 2018

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21 January 2018

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A method for large-scale identification of protein arginine methylation

21 January 2018

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Tyrosine modifications and inactivation of active site manganese superoxide dismutase mutant (Y34F) by peroxynitrite

21 January 2018

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12 December 2020

Experimental autoimmune encephalomyelitis induction in peptidylarginine deiminase 2 knockout mice

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12 December 2020

Protein arginine deiminase 4 (PAD4): Current understanding and future therapeutic potential

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12 December 2020

Protein denitrosylation: enzymatic mechanisms and cellular functions.

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12 December 2020

Autoimmunity to citrullinated type II collagen in rheumatoid arthritis

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12 December 2020

Localization of peptidylarginine deiminase type II in a stage-specific immature oligodendrocyte from rat cerebral hemisphere

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12 December 2020

Netting neutrophils are major inducers of type I IFN production in pediatric systemic lupus erythematosus

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12 December 2020

Identifiers

DOI

10.1038/NI.2873

1 reference

31 August 2017

1 reference

PubMed ID

24840982