The metabolic ER stress sensor IRE1α suppresses alternative activation of macrophages and impairs energy expenditure in obesity. (Q48043703)

7 February 2018

title

The metabolic ER stress sensor IRE1α suppresses alternative activation of macrophages and impairs energy expenditure in obesity. (English)

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7 February 2018

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7

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Yifu Qiu

object named as

Yifu Qiu

17

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author name string

Bo Shan

1

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7 February 2018

Xiaoxia Wang

2

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7 February 2018

Ying Wu

3

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Chi Xu

4

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Zhixiong Xia

5

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7 February 2018

Jianli Dai

6

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7 February 2018

Feng Zhao

8

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7 February 2018

Shengqi He

9

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7 February 2018

Liu Yang

10

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7 February 2018

Mingliang Zhang

11

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7 February 2018

Fajun Nan

12

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7 February 2018

Jia Li

13

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Jianmiao Liu

14

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7 February 2018

Jianfeng Liu

15

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7 February 2018

Weiping Jia

16

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7 February 2018

Baoliang Song

18

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Jing-Dong J Han

19

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7 February 2018

Liangyou Rui

20

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7 February 2018

Sheng-Zhong Duan

21

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7 February 2018

Yong Liu

22

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7 February 2018

language of work or name

English

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publication date

27 March 2017

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7 February 2018

published in

Nature Immunology

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volume

18

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issue

5

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7 February 2018

page(s)

519-529

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7 February 2018

Obesity induces a phenotypic switch in adipose tissue macrophage polarization

cites work

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The immune system as a sensor of the metabolic state

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Alternative activation of macrophages

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Alternatively activated macrophages produce catecholamines to sustain adaptive thermogenesis.

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Eosinophils and type 2 cytokine signaling in macrophages orchestrate development of functional beige fat.

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Meteorin-like is a hormone that regulates immune-adipose interactions to increase beige fat thermogenesis

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The unfolded protein response: from stress pathway to homeostatic regulation

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The unfolded protein response: integrating stress signals through the stress sensor IRE1α

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Increase in endoplasmic reticulum stress-related proteins and genes in adipose tissue of obese, insulin-resistant individuals

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Endoplasmic reticulum stress is reduced in tissues of obese subjects after weight loss

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Getting RIDD of RNA: IRE1 in cell fate regulation

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Brown and Beige Fat: Physiological Roles beyond Heat Generation

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Liposomal clodronate as a novel agent for treating autoimmune hemolytic anemia in a mouse model

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Clodronate liposomes improve metabolic profile and reduce visceral adipose macrophage content in diet-induced obese mice

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Macrophage activation and polarization: nomenclature and experimental guidelines

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PKA phosphorylation couples hepatic inositol-requiring enzyme 1alpha to glucagon signaling in glucose metabolism

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Isolation of high quality RNA and construction of a suppression subtractive hybridization library from ramie (Boehmeria nivea L. Gaud.).

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TLR activation of the transcription factor XBP1 regulates innate immune responses in macrophages.

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Endoplasmic reticulum stress-induced IRE1α activation mediates cross-talk of GSK-3β and XBP-1 to regulate inflammatory cytokine production

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Genetic and functional characterization of clonally derived adult human brown adipocytes

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Beige adipocytes are a distinct type of thermogenic fat cell in mouse and human

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The Jmjd3-Irf4 axis regulates M2 macrophage polarization and host responses against helminth infection

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Interferon regulatory factor 4 regulates obesity-induced inflammation through regulation of adipose tissue macrophage polarization

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Krüppel-like factor 4 regulates macrophage polarization

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Macrophage-specific PPARgamma controls alternative activation and improves insulin resistance

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Adipocyte-derived Th2 cytokines and myeloid PPARdelta regulate macrophage polarization and insulin sensitivity.

21 January 2018

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The molecular basis for selective inhibition of unconventional mRNA splicing by an IRE1-binding small molecule

21 January 2018

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Protein misfolding in the endoplasmic reticulum as a conduit to human disease

21 January 2018

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Endoplasmic reticulum stress links obesity, insulin action, and type 2 diabetes

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Adiponectin Enhances Cold-Induced Browning of Subcutaneous Adipose Tissue via Promoting M2 Macrophage Proliferation.

21 January 2018

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Neutrophils mediate insulin resistance in mice fed a high-fat diet through secreted elastase

21 January 2018

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A switch from white to brown fat increases energy expenditure in cancer-associated cachexia.

21 January 2018

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Signaling by IL-6 promotes alternative activation of macrophages to limit endotoxemia and obesity-associated resistance to insulin

21 January 2018

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21 January 2018

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Differential gene and transcript expression analysis of RNA-seq experiments with TopHat and Cufflinks

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RankProd: a bioconductor package for detecting differentially expressed genes in meta-analysis

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A Phos-tag-based approach reveals the extent of physiological endoplasmic reticulum stress

21 January 2018

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The unfolded protein response: controlling cell fate decisions under ER stress and beyond

21 January 2018

1 reference

inferred from DOI database lookup

7 January 2021

based on heuristic

Hepatic IRE1α regulates fasting-induced metabolic adaptive programs through the XBP1s-PPARα axis signalling.

1 reference

inferred from DOI database lookup

7 January 2021

based on heuristic

Identifiers

DOI

10.1038/NI.3709

1 reference

7 February 2018

PubMed ID

28346409

1 reference

7 February 2018