Cytoplasmically "sequestered" wild type p53 protein is resistant to Mdm2-mediated degradation. (Q48111113)

8 February 2018

title

Cytoplasmically "sequestered" wild type p53 protein is resistant to Mdm2-mediated degradation. (English)

1 reference

8 February 2018

author name string

A Zaika

series ordinal

1

1 reference

8 February 2018

N Marchenko

series ordinal

2

1 reference

8 February 2018

U M Moll

series ordinal

3

1 reference

8 February 2018

language of work or name

English

0 references

publication date

1 September 1999

1 reference

8 February 2018

Journal of Biological Chemistry

published in

1 reference

8 February 2018

volume

274

1 reference

8 February 2018

issue

39

1 reference

8 February 2018

page(s)

27474-27480

1 reference

8 February 2018

Mdm2 promotes the rapid degradation of p53

cites work

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.39.27474

Regulation of p53 stability by Mdm2

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.39.27474

DNA damage-induced phosphorylation of p53 alleviates inhibition by MDM2

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.39.27474

DNA damage induces phosphorylation of the amino terminus of p53

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.39.27474

UV Irradiation Stimulates Levels of p53 Cellular Tumor Antigen in Nontransformed Mouse Cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.39.27474

Design of a synthetic Mdm2-binding mini protein that activates the p53 response in vivo.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.39.27474

Oncoprotein MDM2 is a ubiquitin ligase E3 for tumor suppressor p53

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.39.27474

p300/MDM2 complexes participate in MDM2-mediated p53 degradation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.39.27474

Structure of the MDM2 oncoprotein bound to the p53 tumor suppressor transactivation domain

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.39.27474

Nucleo-cytoplasmic shuttling of the hdm2 oncoprotein regulates the levels of the p53 protein via a pathway used by the human immunodeficiency virus rev protein.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.39.27474

Nuclear export is required for degradation of endogenous p53 by MDM2 and human papillomavirus E6

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.39.27474

Nucleocytoplasmic shuttling of oncoprotein Hdm2 is required for Hdm2-mediated degradation of p53

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.39.27474

Functional and physical interactions of the ARF tumor suppressor with p53 and Mdm2

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.39.27474

The Ink4a tumor suppressor gene product, p19Arf, interacts with MDM2 and neutralizes MDM2's inhibition of p53

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.39.27474

The alternative product from the human CDKN2A locus, p14(ARF), participates in a regulatory feedback loop with p53 and MDM2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.39.27474

Association of p19(ARF) with Mdm2 inhibits ubiquitin ligase activity of Mdm2 for tumor suppressor p53.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.39.27474

Regulation of Mdm2-directed degradation by the C terminus of p53.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.39.27474

Wild-type p53 protein undergoes cytoplasmic sequestration in undifferentiated neuroblastomas but not in differentiated tumors

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.39.27474

Two distinct mechanisms alter p53 in breast cancer: mutation and nuclear exclusion

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.39.27474

Cellular accumulation of p53 protein: an independent prognostic factor in stage II breast cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.39.27474

Novel patterns of p53 abnormality in breast cancer from Taiwan: experience from a low-incidence area

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.39.27474

Nuclear exclusion of wild-type p53 in immortalized human retinoblastoma cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.39.27474

ES cells do not activate p53-dependent stress responses and undergo p53-independent apoptosis in response to DNA damage

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.39.27474

Cytoplasmic sequestration of wild-type p53 protein impairs the G1 checkpoint after DNA damage

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.39.27474

A leucine-rich nuclear export signal in the p53 tetramerization domain: regulation of subcellular localization and p53 activity by NES masking

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.39.27474

Suppression of human colorectal carcinoma cell growth by wild-type p53

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.39.27474

Oncoprotein MDM2 conceals the activation domain of tumour suppressor p53

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.39.27474

ARF promotes MDM2 degradation and stabilizes p53: ARF-INK4a locus deletion impairs both the Rb and p53 tumor suppression pathways

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.39.27474

Substrate targeting in the ubiquitin system

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.39.27474

Human p53 expressed in baculovirus-infected Sf9 cells displays a two-dimensional isoform pattern identical to wild-type p53 from human cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.39.27474

p53 is covalently linked to 5.8S rRNA.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.39.27474

Regulation of the sequence-specific DNA binding function of p53 by protein kinase C and protein phosphatases

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.39.27474

Activation of p53 sequence-specific DNA binding by acetylation of the p53 C-terminal domain

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.39.27474

Cytoplasmically sequestered wild-type p53 protein in neuroblastoma is relocated to the nucleus by a C-terminal peptide

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.39.27474

The human oncoprotein MDM2 arrests the cell cycle: elimination of its cell-cycle-inhibitory function induces tumorigenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.39.27474

Regulation of p53 function and stability by phosphorylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.39.27474

JNK targets p53 ubiquitination and degradation in nonstressed cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.39.27474

Synergistic activation of p53 by inhibition of MDM2 expression and DNA damage

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.39.27474

21 January 2018

Identifiers

DOI

10.1074/JBC.274.39.27474

1 reference

8 February 2018

PubMed ID

10488081

1 reference

8 February 2018