Genetic ablation of Dicer in adult forebrain neurons results in abnormal tau hyperphosphorylation and neurodegeneration (Q48112220)

8 February 2018

title

Genetic ablation of Dicer in adult forebrain neurons results in abnormal tau hyperphosphorylation and neurodegeneration (English)

1 reference

8 February 2018

1 reference

1

1 reference

8 February 2018

Marie-Christine Galas

Marie-Christine Galas

4

0 references

Asli Silahtaroglu

Asli N Silahtaroglu

6

0 references

Luc Buée

Luc Buée

8

0 references

Bart De Strooper

9

Bart De Strooper

1 reference

8 February 2018

author name string

Aikaterini S Papadopoulou

2

1 reference

8 February 2018

Pascal Smith

3

1 reference

8 February 2018

Emmanuel Planel

5

1 reference

8 February 2018

Nicolas Sergeant

7

1 reference

8 February 2018

publication date

21 July 2010

1 reference

8 February 2018

published in

Human Molecular Genetics

1 reference

8 February 2018

volume

19

1 reference

8 February 2018

issue

20

1 reference

8 February 2018

page(s)

3959-3969

1 reference

8 February 2018

The functions of animal microRNAs

cites work

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDQ311

Gene regulation by transcription factors and microRNAs

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDQ311

Targeted deletion reveals essential and overlapping functions of the miR-17 through 92 family of miRNA clusters

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDQ311

Cerebellar neurodegeneration in the absence of microRNAs

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDQ311

A MicroRNA feedback circuit in midbrain dopamine neurons

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDQ311

Conditional loss of Dicer disrupts cellular and tissue morphogenesis in the cortex and hippocampus

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDQ311

Dicer loss in striatal neurons produces behavioral and neuroanatomical phenotypes in the absence of neurodegeneration

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDQ311

Alterations of the microRNA network cause neurodegenerative disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDQ311

miRNAs are essential for survival and differentiation of newborn neurons but not for expansion of neural progenitors during early neurogenesis in the mouse embryonic neocortex

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDQ311

Tau-mediated neurodegeneration in Alzheimer's disease and related disorders

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDQ311

Tau in Alzheimer's disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDQ311

MicroRNA pathways modulate polyglutamine-induced neurodegeneration.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDQ311

The cochaperone BAG2 sweeps paired helical filament- insoluble tau from the microtubule.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDQ311

APP processing and synaptic plasticity in presenilin-1 conditional knockout mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDQ311

Characterization of the neuronal marker NeuN as a multiply phosphorylated antigen with discrete subcellular localization.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDQ311

Characterization of mAb AP422, a novel phosphorylation-dependent monoclonal antibody against tau protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDQ311

Tau therapeutic strategies for the treatment of Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDQ311

Untangling tau hyperphosphorylation in drug design for neurodegenerative diseases.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDQ311

MicroRNA-206: the skeletal muscle-specific myomiR.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDQ311

MicroRNA expression in the adult mouse central nervous system

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDQ311

Knockout of ERK1 MAP kinase enhances synaptic plasticity in the striatum and facilitates striatal-mediated learning and memory

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDQ311

Normalization of microRNA expression levels in quantitative RT-PCR assays: identification of suitable reference RNA targets in normal and cancerous human solid tissues

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDQ311

Identification of suitable endogenous control genes for microRNA gene expression analysis in human breast cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDQ311

Loss of microRNA cluster miR-29a/b-1 in sporadic Alzheimer's disease correlates with increased BACE1/beta-secretase expression

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDQ311

Joint genome-wide profiling of miRNA and mRNA expression in Alzheimer's disease cortex reveals altered miRNA regulation

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDQ311

Activation of neuronal extracellular receptor kinase (ERK) in Alzheimer disease links oxidative stress to abnormal phosphorylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDQ311

Microtubule-associated protein 2 kinases, ERK1 and ERK2, undergo autophosphorylation on both tyrosine and threonine residues: implications for their mechanism of activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDQ311

Significance and mechanism of Alzheimer neurofibrillary degeneration and therapeutic targets to inhibit this lesion

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDQ311

Micro-RNA speciation in fetal, adult and Alzheimer's disease hippocampus

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDQ311

The expression of microRNA miR-107 decreases early in Alzheimer's disease and may accelerate disease progression through regulation of beta-site amyloid precursor protein-cleaving enzyme 1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDQ311

Exclusive branching-fraction measurements of semileptonic tau decays into three charged hadrons, into phipi(-)nu tau, and into phi K(-)nu tau.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDQ311

The expression of the Alzheimer's amyloid precursor protein-like gene is regulated by developmental timing microRNAs and their targets in Caenorhabditis elegans

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDQ311

MicroRNA regulation of Alzheimer's Amyloid precursor protein expression.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDQ311

MicroRNAs in neurodegeneration

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDQ311

The peptidylprolyl cis/trans-isomerase Pin1 modulates stress-induced dephosphorylation of Tau in neurons. Implication in a pathological mechanism related to Alzheimer disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDQ311

The RNaseIII enzyme Dicer is required for morphogenesis but not patterning of the vertebrate limb

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDQ311

Regulated intramembrane proteolysis of amyloid precursor protein and regulation of expression of putative target genes

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDQ311

Two-dimensional electrophoresis of tau mutants reveals specific phosphorylation pattern likely linked to early tau conformational changes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDQ311

Alzheimer's disease-like tau neuropathology leads to memory deficits and loss of functional synapses in a novel mutated tau transgenic mouse without any motor deficits

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDQ311

Alterations in glucose metabolism induce hypothermia leading to tau hyperphosphorylation through differential inhibition of kinase and phosphatase activities: implications for Alzheimer's disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDQ311

Tau protein isoforms, phosphorylation and role in neurodegenerative disorders11These authors contributed equally to this work

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDQ311

Identification of miRNA Changes in Alzheimer's Disease Brain and CSF Yields Putative Biomarkers and Insights into Disease Pathways

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDQ311

21 January 2018

Identifiers

DOI

10.1093/HMG/DDQ311

1 reference

8 February 2018

1 reference

8 February 2018