The neuronal adaptor protein X11alpha reduces Abeta levels in the brains of Alzheimer's APPswe Tg2576 transgenic mice (Q48199895)

9 February 2018

title

The neuronal adaptor protein X11alpha reduces Abeta levels in the brains of Alzheimer's APPswe Tg2576 transgenic mice (English)

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9 February 2018

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7

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Declan McLoughlin

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Kwok-Fai Lau

object named as

Kwok-Fai Lau

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author name string

Ju-Hyun Lee

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9 February 2018

Michael S Perkinton

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9 February 2018

Claire L Standen

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9 February 2018

Stephen J A Shemilt

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Luc Mercken

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9 February 2018

Christopher C J Miller

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language of work or name

English

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publication date

11 September 2003

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9 February 2018

Journal of Biological Chemistry

published in

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volume

278

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issue

47

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9 February 2018

page(s)

47025-47029

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9 February 2018

The amyloid hypothesis of Alzheimer's disease: progress and problems on the road to therapeutics

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The neuronal adaptor protein X11alpha interacts with the copper chaperone for SOD1 and regulates SOD1 activity

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The X11alpha protein slows cellular amyloid precursor protein processing and reduces Abeta40 and Abeta42 secretion

21 January 2018

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X11 interaction with beta-amyloid precursor protein modulates its cellular stabilization and reduces amyloid beta-protein secretion

21 January 2018

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21 January 2018

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21 January 2018

Identifiers

DOI

10.1074/JBC.M300503200

1 reference

9 February 2018

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9 February 2018