miR-181 elevates Akt signaling by co-targeting PHLPP2 and INPP4B phosphatases in luminal breast cancer. (Q48209624)

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3 April 2020

title

miR-181 elevates Akt signaling by co-targeting PHLPP2 and INPP4B phosphatases in luminal breast cancer (English)

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5

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Monilola A Olayioye

6

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4

Melanie Boerries

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3 April 2020

author name string

Michaela Strotbek

1

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Simone Schmid

2

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Ismael Sánchez-González

3

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language of work or name

English

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publication date

11 March 2017

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International Journal of Cancer

3 April 2020

published in

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volume

140

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page(s)

2310-2320

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issue

10

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Gene expression patterns of breast carcinomas distinguish tumor subclasses with clinical implications

3 April 2020

cites work

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Gene expression profiling identifies molecular subtypes of inflammatory breast cancer

21 January 2018

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New strategies in estrogen receptor-positive breast cancer

21 January 2018

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PI3K pathway activation in breast cancer is associated with the basal-like phenotype and cancer-specific mortality

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Targeting the phosphoinositide 3-kinase pathway in cancer

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PI(3,4,5)P3 and PI(3,4)P2 levels correlate with PKB/akt phosphorylation at Thr308 and Ser473, respectively; PI(3,4)P2 levels determine PKB activity.

21 January 2018

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Tenets of PTEN tumor suppression

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Inositol polyphosphate 4-phosphatase II regulates PI3K/Akt signaling and is lost in human basal-like breast cancers

21 January 2018

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Evidence that inositol polyphosphate 4-phosphatase type II is a tumor suppressor that inhibits PI3K signaling

21 January 2018

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Phosphoinositide 3-kinase and INPP4B in human breast cancer

21 January 2018

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PHLPP and a second isoform, PHLPP2, differentially attenuate the amplitude of Akt signaling by regulating distinct Akt isoforms

21 January 2018

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PHLPP: a phosphatase that directly dephosphorylates Akt, promotes apoptosis, and suppresses tumor growth

21 January 2018

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Suppression of survival signalling pathways by the phosphatase PHLPP

21 January 2018

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The functions of animal microRNAs

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MicroRNAs: target recognition and regulatory functions

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Widespread changes in protein synthesis induced by microRNAs

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A global microRNA screen identifies regulators of the ErbB receptor signaling network

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The role of HER3, the unpretentious member of the HER family, in cancer biology and cancer therapeutics

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A noncommercial dual luciferase enzyme assay system for reporter gene analysis

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STAT3 activation of miR-21 and miR-181b-1 via PTEN and CYLD are part of the epigenetic switch linking inflammation to cancer

21 January 2018

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Anti-microRNA-222 (anti-miR-222) and -181B suppress growth of tamoxifen-resistant xenografts in mouse by targeting TIMP3 protein and modulating mitogenic signal.

21 January 2018

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TGF-β upregulates miR-181a expression to promote breast cancer metastasis

21 January 2018

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Induction of miRNA-181a by genotoxic treatments promotes chemotherapeutic resistance and metastasis in breast cancer

21 January 2018

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A novel positive feedback loop mediated by the docking protein Gab1 and phosphatidylinositol 3-kinase in epidermal growth factor receptor signaling

21 January 2018

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ErbB-2, the preferred heterodimerization partner of all ErbB receptors, is a mediator of lateral signaling

21 January 2018

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Pleckstrin homology domain leucine-rich repeat protein phosphatases set the amplitude of receptor tyrosine kinase output.

21 January 2018

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Proteomic and transcriptomic profiling reveals a link between the PI3K pathway and lower estrogen-receptor (ER) levels and activity in ER+ breast cancer

21 January 2018

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Cycles of ubiquitination and deubiquitination critically regulate growth factor-mediated activation of Akt signaling

21 January 2018

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Phosphatase and tensin homolog deleted on chromosome 10 (PTEN) and PH domain and leucine-rich repeat phosphatase cross-talk (PHLPP) in cancer cells and in transforming growth factor β-activated stem cells

21 January 2018

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Identification of PHLPP1 as a tumor suppressor reveals the role of feedback activation in PTEN-mutant prostate cancer progression

21 January 2018

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MicroRNA-221/222 confers tamoxifen resistance in breast cancer by targeting p27Kip1

21 January 2018

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Widespread estrogen-dependent repression of micrornas involved in breast tumor cell growth

21 January 2018

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Targeting the PI3K/AKT/mTOR pathway in estrogen receptor-positive breast cancer

21 January 2018

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Phosphatidylinositol 3-kinase and antiestrogen resistance in breast cancer

21 January 2018

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ERα-dependent E2F transcription can mediate resistance to estrogen deprivation in human breast cancer

21 January 2018

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ErbB3 downregulation enhances luminal breast tumor response to antiestrogens

21 January 2018

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PI3K inhibition results in enhanced estrogen receptor function and dependence in hormone receptor-positive breast cancer

21 January 2018

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Overcoming endocrine resistance due to reduced PTEN levels in estrogen receptor-positive breast cancer by co-targeting mammalian target of rapamycin, protein kinase B, or mitogen-activated protein kinase kinase.

21 January 2018

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21 January 2018

Identifiers

DOI

10.1002/IJC.30661

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3 April 2020

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