Phosphatidylinositol 3-kinase and antiestrogen resistance in breast cancer (Q26862550)

Crossref

J. M. Balko

series ordinal

2

1 reference

Crossref

C. L. Arteaga

series ordinal

3

1 reference

Crossref

language of work or name

1 reference

20 November 2011

1 reference

Journal of Clinical Oncology

published in

1 reference

volume

29

1 reference

issue

33

1 reference

page(s)

4452-61

1 reference

Deregulation of the PI3K and KRAS signaling pathways in human cancer cells determines their response to everolimus

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Type I phosphatidylinositol kinase makes a novel inositol phospholipid, phosphatidylinositol-3-phosphate

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mTOR inhibition induces upstream receptor tyrosine kinase signaling and activates Akt

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Identification and characterization of NVP-BEZ235, a new orally available dual phosphatidylinositol 3-kinase/mammalian target of rapamycin inhibitor with potent in vivo antitumor activity

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AKT inhibition relieves feedback suppression of receptor tyrosine kinase expression and activity

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Inositol polyphosphate 4-phosphatase II regulates PI3K/Akt signaling and is lost in human basal-like breast cancers

28 September 2017

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PIK3CA Mutations May Be Discordant between Primary and Corresponding Metastatic Disease in Breast Cancer

28 September 2017

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Proteomic and transcriptomic profiling reveals a link between the PI3K pathway and lower estrogen-receptor (ER) levels and activity in ER+ breast cancer

28 September 2017

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PIK3CA mutations in in situ and invasive breast carcinomas

28 September 2017

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Hyperactivation of phosphatidylinositol-3 kinase promotes escape from hormone dependence in estrogen receptor-positive human breast cancer

28 September 2017

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PIK3CA mutations associated with gene signature of low mTORC1 signaling and better outcomes in estrogen receptor-positive breast cancer

28 September 2017

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Resiliency and vulnerability in the HER2-HER3 tumorigenic driver

28 September 2017

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Somatic mutations in p85alpha promote tumorigenesis through class IA PI3K activation

28 September 2017

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Inhibition of mammalian target of rapamycin is required for optimal antitumor effect of HER2 inhibitors against HER2-overexpressing cancer cells

28 September 2017

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Phosphatidyl-inositol-3-kinase alpha catalytic subunit mutation and response to neoadjuvant endocrine therapy for estrogen receptor positive breast cancer

28 September 2017

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Evidence that inositol polyphosphate 4-phosphatase type II is a tumor suppressor that inhibits PI3K signaling

28 September 2017

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3-Phosphoinositide-dependent kinase 1 potentiates upstream lesions on the phosphatidylinositol 3-kinase pathway in breast carcinoma

28 September 2017

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PIK3CA and PIK3CB inhibition produce synthetic lethality when combined with estrogen deprivation in estrogen receptor-positive breast cancer

28 September 2017

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Linking somatic genetic alterations in cancer to therapeutics

28 September 2017

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Trastuzumab reverses letrozole resistance and amplifies the sensitivity of breast cancer cells to estrogen

28 September 2017

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S6 kinase 1 regulates estrogen receptor alpha in control of breast cancer cell proliferation

28 September 2017

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Phosphorylated insulin-like growth factor-i/insulin receptor is present in all breast cancer subtypes and is related to poor survival.

28 September 2017

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Outcome prediction for estrogen receptor-positive breast cancer based on postneoadjuvant endocrine therapy tumor characteristics

28 September 2017

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Drug discovery approaches targeting the PI3K/Akt pathway in cancer

28 September 2017

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An integrative genomic and proteomic analysis of PIK3CA, PTEN, and AKT mutations in breast cancer

28 September 2017

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Activation of ErbB3, EGFR and Erk is essential for growth of human breast cancer cell lines with acquired resistance to fulvestrant

28 September 2017

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The role of amphiregulin in exemestane-resistant breast cancer cells: evidence of an autocrine loop

28 September 2017

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Helical domain and kinase domain mutations in p110alpha of phosphatidylinositol 3-kinase induce gain of function by different mechanisms

28 September 2017

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Tamoxifen resistance in breast tumors is driven by growth factor receptor signaling with repression of classic estrogen receptor genomic function

28 September 2017

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Crosstalk between the estrogen receptor and the HER tyrosine kinase receptor family: molecular mechanism and clinical implications for endocrine therapy resistance

28 September 2017

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A vascular targeted pan phosphoinositide 3-kinase inhibitor prodrug, SF1126, with antitumor and antiangiogenic activity

28 September 2017

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Discovery of lactoquinomycin and related pyranonaphthoquinones as potent and allosteric inhibitors of AKT/PKB: mechanistic involvement of AKT catalytic activation loop cysteines

28 September 2017

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Estrogen receptor DNA binding is not required for estrogen-induced breast cell growth

28 September 2017

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Inhibition of the phosphatidylinositol 3-kinase/Akt pathway improves response of long-term estrogen-deprived breast cancer xenografts to antiestrogens

28 September 2017

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Poor prognosis in carcinoma is associated with a gene expression signature of aberrant PTEN tumor suppressor pathway activity.

28 September 2017

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Unraveling the mechanisms of endocrine resistance in breast cancer: new therapeutic opportunities

28 September 2017

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Role of receptor complexes in the extranuclear actions of estrogen receptor alpha in breast cancer

28 September 2017

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Diverse gene expression and DNA methylation profiles correlate with differential adaptation of breast cancer cells to the antiestrogens tamoxifen and fulvestrant

28 September 2017

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Mechanisms of tumor regression and resistance to estrogen deprivation and fulvestrant in a model of estrogen receptor-positive, HER-2/neu-positive breast cancer

28 September 2017

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A variant of estrogen receptor-{alpha}, hER-{alpha}36: transduction of estrogen- and antiestrogen-dependent membrane-initiated mitogenic signaling

28 September 2017

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A model of acquired autoresistance to a potent ErbB2 tyrosine kinase inhibitor and a therapeutic strategy to prevent its onset in breast cancer

28 September 2017

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Reverting estrogen-receptor-negative phenotype in HER-2-overexpressing advanced breast cancer patients exposed to trastuzumab plus chemotherapy

28 September 2017

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Breast cancer-associated PIK3CA mutations are oncogenic in mammary epithelial cells

28 September 2017

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Farnesylthiosalicylic acid blocks mammalian target of rapamycin signaling in breast cancer cells

28 September 2017

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Mechanisms of tamoxifen resistance: increased estrogen receptor-HER2/neu cross-talk in ER/HER2-positive breast cancer

28 September 2017

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Plasma membrane localization and function of the estrogen receptor alpha variant (ER46) in human endothelial cells

28 September 2017

1 reference

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Interaction of oestrogen receptor with the regulatory subunit of phosphatidylinositol-3-OH kinase

28 September 2017

1 reference

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Phosphatidylinositol 3-kinase mediates epidermal growth factor-induced activation of the c-Jun N-terminal kinase signaling pathway.

28 September 2017

1 reference

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Phosphoinositide 3-kinases: a conserved family of signal transducers

28 September 2017

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Fos-associated protein p39 is the product of the jun proto-oncogene

28 September 2017

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Luminal expression of PIK3CA mutant H1047R in the mammary gland induces heterogeneous tumors

28 September 2017

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Down-regulation of phosphatidylinositol 3'-kinase/AKT/molecular target of rapamycin metabolic pathway by primary letrozole-based therapy in human breast cancer

31 May 2018

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Estrogen-dependent, tamoxifen-resistant tumorigenic growth of MCF-7 cells transfected with HER2/neu

31 May 2018

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HER-2 tyrosine kinase pathway targets estrogen receptor and promotes hormone-independent growth in human breast cancer cells.

31 May 2018

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Development of tamoxifen-stimulated growth of MCF-7 tumors in athymic mice after long-term antiestrogen administration

31 May 2018

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Incidence of activating ras oncogene mutations associated with primary and metastatic human breast cancer

31 May 2018

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Phase II, randomized trial to compare anastrozole combined with gefitinib or placebo in postmenopausal women with hormone receptor-positive metastatic breast cancer

31 May 2018

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Lapatinib combined with letrozole versus letrozole and placebo as first-line therapy for postmenopausal hormone receptor-positive metastatic breast cancer

28 November 2018

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Activity of fulvestrant 500 mg versus anastrozole 1 mg as first-line treatment for advanced breast cancer: results from the FIRST study.

28 November 2018

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Phase II randomized study of neoadjuvant everolimus plus letrozole compared with placebo plus letrozole in patients with estrogen receptor-positive breast cancer

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3221526

Characterization of an Akt kinase inhibitor with potent pharmacodynamic and antitumor activity

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3221526

Effect of anastrozole and tamoxifen as adjuvant treatment for early-stage breast cancer: 100-month analysis of the ATAC trial

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3221526

A phase II, randomized, blinded study of the farnesyltransferase inhibitor tipifarnib combined with letrozole in the treatment of advanced breast cancer after antiestrogen therapy

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3221526

PIK3CA mutations and PTEN loss correlate with similar prognostic factors and are not mutually exclusive in breast cancer

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3221526

Nature of functional estrogen receptors at the plasma membrane

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3221526

A meta-analysis on the interaction between HER-2 expression and response to endocrine treatment in advanced breast cancer

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3221526

Molecular changes in tamoxifen-resistant breast cancer: relationship between estrogen receptor, HER-2, and p38 mitogen-activated protein kinase

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3221526

Reduced PTEN expression predicts relapse in patients with breast carcinoma treated by tamoxifen

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3221526

HER-2 amplification, HER-1 expression, and tamoxifen response in estrogen receptor-positive metastatic breast cancer: a southwest oncology group study

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3221526

Studies of the potential utility of Ki67 as a predictive molecular marker of clinical response in primary breast cancer

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3221526

Serum HER-2/neu and Response to the Aromatase Inhibitor Letrozole Versus Tamoxifen

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3221526

Estrogen receptor alpha and activating protein-1 mediate estrogen responsiveness of the progesterone receptor gene in MCF-7 breast cancer cells

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3221526

Molecular alterations of the AKT2 oncogene in ovarian and breast carcinomas

28 November 2018

1 reference

12 December 2020

Mutation of the PIK3CA gene in ovarian and breast cancer

1 reference

12 December 2020

Estrogen-independent proliferation is present in estrogen-receptor HER2-positive primary breast cancer after neoadjuvant letrozole

1 reference

12 December 2020

Trastuzumab plus anastrozole versus anastrozole alone for the treatment of postmenopausal women with human epidermal growth factor receptor 2-positive, hormone receptor-positive metastatic breast cancer: results from the randomized phase III TAnDEM

1 reference

12 December 2020

Prognostic value of Ki67 expression after short-term presurgical endocrine therapy for primary breast cancer

1 reference

12 December 2020

mTOR inhibitors in the treatment of cancer

1 reference

12 December 2020

Prognostic relevance of gene amplifications and coamplifications in breast cancer

1 reference

12 December 2020

Class IA phosphatidylinositol 3-kinase: from their biologic implication in human cancers to drug discovery

1 reference

12 December 2020

A phase II placebo-controlled trial of neoadjuvant anastrozole alone or with gefitinib in early breast cancer

1 reference

12 December 2020

Reduced apoptosis and proliferation and increased Bcl-2 in residual breast cancer following preoperative chemotherapy

1 reference

12 December 2020

Identifiers

DOI

10.1200/JCO.2010.34.4879

1 reference

release_qefumdblpjbzzhxhbux73xxw44

Fatcat ID

0 references

1 reference

1 reference

PubMed publication ID

22010023

1 reference