RNA splicing and editing modulation of 5-HT(2C) receptor function: relevance to anxiety and aggression in VGV mice. (Q48250554)

10 February 2018

title

RNA splicing and editing modulation of 5-HT(2C) receptor function: relevance to anxiety and aggression in VGV mice. (English)

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10 February 2018

author name string

C B P Martin

1

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10 February 2018

F Ramond

2

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10 February 2018

D T Farrington

3

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10 February 2018

A S Aguiar

4

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10 February 2018

C Chevarin

5

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10 February 2018

A-S Berthiau

6

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10 February 2018

S Caussanel

7

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10 February 2018

L Lanfumey

8

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10 February 2018

K Herrick-Davis

9

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10 February 2018

M Hamon

10

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10 February 2018

J J Madjar

11

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10 February 2018

R Mongeau

12

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10 February 2018

language of work or name

English

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publication date

18 December 2012

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10 February 2018

number of pages

10

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inferred from page(s)

published in

Molecular Psychiatry

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10 February 2018

volume

18

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10 February 2018

page(s)

656-665

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10 February 2018

issue

6

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10 February 2018

https://scigraph.springernature.com/pub.10.1038/mp.2012.171

exact match

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cites work

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Serotonin2C receptor localization in GABA neurons of the rat medial prefrontal cortex: implications for understanding the neurobiology of addiction

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5-HT2C receptor activation prevents stress-induced enhancement of brain 5-HT turnover and extracellular levels in the mouse brain: modulation by chronic paroxetine treatment

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Pituitary hormone responses to meta-chlorophenylpiperazine in panic disorder and healthy control subjects.

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Behavioural effects of rapid intravenous administration of meta-chlorophenylpiperazine (m-CPP) in patients with generalized social anxiety disorder, panic disorder and healthy controls

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Hypersensitivity of 5-HT2 receptors in OCD patients. An increased prolactin response after a challenge with meta-chlorophenylpiperazine and pre-treatment with ritanserin and placebo

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Promoter and functional polymorphisms of HTR2C and suicide victims.

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Further evidence supporting the association between 5HTR2C gene and bipolar disorder

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Neuroimaging and 5-HT2C receptor polymorphism: a HMPAO-SPECT study in healthy male probands using mCPP-challenge of the 5-HT2C receptor

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Neuroprotective effect of a chuk-me-sun-dan on neurons from ischemic damage and neuronal cell toxicity

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RNA editing of the human serotonin 5-HT2C receptor disrupts transactivation of the small G-protein RhoA.

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RNA editing of the human serotonin 5-hydroxytryptamine 2C receptor silences constitutive activity

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Altered editing of serotonin 2C receptor pre-mRNA in the prefrontal cortex of depressed suicide victims

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RNA editing of the human serotonin 5-HT2C receptor. alterations in suicide and implications for serotonergic pharmacotherapy

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RNA editing of serotonin 2C receptor in human postmortem brains of major mental disorders

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Dysregulated editing of serotonin 2C receptor mRNAs results in energy dissipation and loss of fat mass

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Evidence that RNA editing modulates splice site selection in the 5-HT2C receptor gene

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Altered serotonin 2C receptor RNA splicing in suicide: association with editing

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Mice with altered serotonin 2C receptor RNA editing display characteristics of Prader-Willi syndrome

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Functional relevance of serotonin 2C receptor mRNA editing in antidepressant- and anxiety-like behaviors

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Mitochondrial uncoupling as a target for drug development for the treatment of obesity

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5-hydroxytryptamine 2C receptors in the basolateral amygdala are involved in the expression of anxiety after uncontrollable traumatic stress

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Endogenous serotonin acts on 5-HT2C-like receptors in key vocal areas of the brain stem to initiate vocalizations in Xenopus laevis

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The truncated ghrelin receptor polypeptide (GHS-R1b) acts as a dominant-negative mutant of the ghrelin receptor

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Biochemical and biophysical characterization of serotonin 5-HT2C receptor homodimers on the plasma membrane of living cells

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Serotonin 5-HT(2C) receptor homodimerization is not regulated by agonist or inverse agonist treatment

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Neuroprotective effects of erythropoietin in the rat hippocampus after pilocarpine-induced status epilepticus

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Loss of the imprinted snoRNA mbii-52 leads to increased 5htr2c pre-RNA editing and altered 5HT2CR-mediated behaviour

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Editing of the serotonin 2C receptor pre-mRNA: Effects of the Morris Water Maze

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Mild mitochondrial uncoupling in mice affects energy metabolism, redox balance and longevity.

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Regulation of alternative splicing by snoRNAs

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RNA Editing Induces Variation in Desensitization and Trafficking of 5-Hydroxytryptamine 2c Receptor Isoforms

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Serotonin 5-HT2C receptor RNA editing alters receptor basal activity: implications for serotonergic signal transduction

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Overexpression of 5-HT2C receptors in forebrain leads to elevated anxiety and hypoactivity.

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Activation of the serotonin 5-HT2C receptor is involved in the enhanced anxiety in rats after single-prolonged stress

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Amygdalar roles during exposure to a live predator and to a predator-associated context.

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Acute selective serotonin reuptake inhibitors increase conditioned fear expression: blockade with a 5-HT(2C) receptor antagonist

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Neuroendocrine response to meta-chlorophenylpiperazine and ipsapirone in relation to anxiety and aggression

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G-protein-coupled receptor heterodimerization modulates receptor function

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Inhibition of serotonin 5-hydroxytryptamine2c receptor function through heterodimerization: receptor dimers bind two molecules of ligand and one G-protein

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Functional rescue of the inactive splice variant of the dopamine D3 receptor D3nf

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Relative expression of D3 dopamine receptor and alternative splice variant D3nf mRNA in high and low responders to novelty

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Identification and characterization of a truncated variant of the 5-hydroxytryptamine(2A) receptor produced by alternative splicing

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Identification of a human 5-HT6 receptor variant produced by alternative splicing.

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The natural mutation encoding a C terminus-truncated 5-hydroxytryptamine 2B receptor is a gain of proliferative functions

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Regulation of serotonin-2C receptor G-protein coupling by RNA editing

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Serotonin dysregulation in adolescents with major depression: hormone response to meta-chlorophenylpiperazine (mCPP) infusion

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7 January 2021

Regional distribution and relative abundance of serotonin(2c) receptors in human brain: effect of suicide

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Neural correlates of competing fear behaviors evoked by an innately aversive stimulus.

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Antagonist binding at 5-HT(2A) and 5-HT(2C) receptors in the rabbit: high correlation with the profile for the human receptors

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Anxiety-like effects induced by acute fluoxetine, sertraline or m-CPP treatment are reversed by pretreatment with the 5-HT2C receptor antagonist SB-242084 but not the 5-HT1A receptor antagonist WAY-100635.

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Citalopram reduces social interaction in rats by activation of serotonin (5-HT)(2C) receptors

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7 January 2021

HTR2C andHTR1A gene variants in German and Italian suicide attempters and completers

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Homicide, suicide and CSF 5-HIAA

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Enhanced cleavage of an atypical intron of dopamine D3-receptor pre-mRNA in chronic schizophrenia.

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RNA editing and alternative splicing of human serotonin 2C receptor in schizophrenia.

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7 January 2021

Identifiers

DOI

10.1038/MP.2012.171

1 reference

10 February 2018

PubMed ID

23247076

1 reference

10 February 2018