Pax5 promotes B lymphopoiesis and blocks T cell development by repressing Notch1. (Q48269882)

10 February 2018

title

Pax5 promotes B lymphopoiesis and blocks T cell development by repressing Notch1. (English)

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10 February 2018

author

César Cobaleda

2

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10 February 2018

Meinrad Busslinger

4

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10 February 2018

author name string

Abdallah Souabni

1

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10 February 2018

Michael Schebesta

3

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10 February 2018

language of work or name

English

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publication date

1 December 2002

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10 February 2018

published in

Immunity

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10 February 2018

volume

17

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10 February 2018

issue

6

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10 February 2018

page(s)

781-793

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10 February 2018

Ikaros sets thresholds for T cell activation and regulates chromosome propagation

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Flk-2 is a marker in hematopoietic stem cell differentiation: a simple method to isolate long-term stem cells

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Intraembryonic, but Not Yolk Sac Hematopoietic Precursors, Isolated before Circulation, Provide Long-Term Multilineage Reconstitution

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Regulation of B lymphocyte and macrophage development by graded expression of PU.1.

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PU.1 regulates both cytokine-dependent proliferation and differentiation of granulocyte/macrophage progenitors

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Multilineage gene expression precedes commitment in the hemopoietic system

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Commitment to natural killer cells requires the helix-loop-helix inhibitor Id2

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Deciphering the role of Notch signaling in lymphopoiesis

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Helios, a novel dimerization partner of Ikaros expressed in the earliest hematopoietic progenitors

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7 January 2021

Hematopoietic stem cells and lymphoid progenitors express different Ikaros isoforms, and Ikaros is localized to heterochromatin in immature lymphocytes.

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Initiation of translation in prokaryotes and eukaryotes

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The promoter of the CD19 gene is a target for the B-cell-specific transcription factor BSAP

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Inducible gene targeting in mice

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Impairment of T and B cell development by treatment with a type I interferon

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Reversion of B cell commitment upon loss of Pax5 expression

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Aiolos, a lymphoid restricted transcription factor that interacts with Ikaros to regulate lymphocyte differentiation

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Essential functions of Pax5 (BSAP) in pro-B cell development: difference between fetal and adult B lymphopoiesis and reduced V-to-DJ recombination at the IgH locus.

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Identification of BSAP (Pax-5) target genes in early B-cell development by loss- and gain-of-function experiments

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7 January 2021

Commitment to the B-lymphoid lineage depends on the transcription factor Pax5

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7 January 2021

Notch1 expression in early lymphopoiesis influences B versus T lineage determination.

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7 January 2021

Deficient T cell fate specification in mice with an induced inactivation of Notch1.

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7 January 2021

An interleukin-2 signal relieves BSAP (Pax5)-mediated repression of the immunoglobulin J chain gene

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7 January 2021

Long-term in vivo reconstitution of T-cell development by Pax5-deficient B-cell progenitors

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7 January 2021

Transcriptional control of B-cell development

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7 January 2021

Control of pre-BCR signaling by Pax5-dependent activation of the BLNK gene.

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7 January 2021

Complete block of early B cell differentiation and altered patterning of the posterior midbrain in mice lacking Pax5/BSAP

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7 January 2021

Cre expression in primary spermatocytes: a tool for genetic engineering of the germ line

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Pleiotropic changes controlled by the pre-T-cell receptor

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7 January 2021

Selective defects in the development of the fetal and adult lymphoid system in mice with an Ikaros null mutation

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7 January 2021

Notch activity influences the alphabeta versus gammadelta T cell lineage decision

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7 January 2021

Inactivation of Notch1 impairs VDJbeta rearrangement and allows pre-TCR-independent survival of early alpha beta Lineage Thymocytes.

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Cell-autonomous defects in dendritic cell populations of Ikaros mutant mice point to a developmental relationship with the lymphoid lineage.

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7 January 2021

Development of peripheral lymphoid organs and natural killer cells depends on the helix-loop-helix inhibitor Id2.

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7 January 2021

10.1016/S1074-7613(02)00472-7

Identifiers

DOI

1 reference

10 February 2018

release_arpjjcqrrzd4hadp7r2xgihfmi

Fatcat ID

1 reference

Fatcat

https://api.fatcat.wiki/v0/release/arpjjcqrrzd4hadp7r2xgihfmi

24 November 2022

mapped directly with Wikidata item

PubMed ID

12479824

1 reference

10 February 2018