Intranasal administration of antiretroviral-loaded micelles for anatomical targeting to the brain in HIV. (Q48284053)

10 February 2018

title

Intranasal administration of antiretroviral-loaded micelles for anatomical targeting to the brain in HIV. (English)

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10 February 2018

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Christian Hocht

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10 February 2018

Javier A W Opezzo

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3

object named as

Javier A W Opezzo

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10 February 2018

author name string

Diego A Chiappetta

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1

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10 February 2018

Alejandro Sosnik

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4

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10 February 2018

publication date

22 November 2012

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10 February 2018

published in

Nanomedicine

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10 February 2018

volume

8

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10 February 2018

issue

2

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10 February 2018

page(s)

223-237

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10 February 2018

https://api.crossref.org/works/10.2217%2FNNM.12.104

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Use of virostatics as a means of targeting human immunodeficiency virus infection

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FNNM.12.104

P-glycoprotein and mutlidrug resistance-associated proteins limit the brain uptake of saquinavir in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FNNM.12.104

Hide-and-seek: the challenge of viral persistence in HIV-1 infection

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FNNM.12.104

Examination of the ability of the nasal administration route to confer a brain exposure advantage for three chemical inhibitors of P-glycoprotein

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FNNM.12.104

Population pharmacokinetics and effects of efavirenz in patients with human immunodeficiency virus infection

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FNNM.12.104

Therapeutic drug monitoring: an aid to optimising response to antiretroviral drugs?

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FNNM.12.104

P-glycoprotein, secretory transport, and other barriers to the oral delivery of anti-HIV drugs

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FNNM.12.104

P-glycoprotein-mediated active efflux of the anti-HIV1 nucleoside abacavir limits cellular accumulation and brain distribution

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FNNM.12.104

Regulation of ABC membrane transporters in glial cells: relevance to the pharmacotherapy of brain HIV-1 infection

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FNNM.12.104

Influence of highly active antiretroviral therapy on persistence of HIV in the central nervous system

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FNNM.12.104

Molecular pathology of neuro-AIDS (CNS-HIV).

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FNNM.12.104

Loss of neuronal integrity during progressive HIV-1 infection of humanized mice

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FNNM.12.104

Thinking about HIV: the intersection of virus, neuroinflammation and cognitive dysfunction

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FNNM.12.104

Impact of the HIV/AIDS epidemic on the neurodevelopment of preschool-aged children in Kinshasa, Democratic Republic of the Congo.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FNNM.12.104

Highly active antiretroviral therapy of cognitive dysfunction and neuronal abnormalities in SCID mice with HIV encephalitis

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FNNM.12.104

Drug delivery systems in HIV pharmacotherapy: what has been done and the challenges standing ahead.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FNNM.12.104

Nanotechnology applications for improved delivery of antiretroviral drugs to the brain

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FNNM.12.104

Transport of stavudine, delavirdine, and saquinavir across the blood-brain barrier by polybutylcyanoacrylate, methylmethacrylate-sulfopropylmethacrylate, and solid lipid nanoparticles.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FNNM.12.104

Electromagnetic interference in the permeability of saquinavir across the blood-brain barrier using nanoparticulate carriers

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FNNM.12.104

Solid lipid nanoparticles enhance the delivery of the HIV protease inhibitor, atazanavir, by a human brain endothelial cell line

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FNNM.12.104

Targeted brain delivery of AZT via transferrin anchored pegylated albumin nanoparticles.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FNNM.12.104

Interactions of pluronic block copolymers on P-gp efflux activity: experience with HIV-1 protease inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FNNM.12.104

Investigation of the micellar effect of pluronic P85 on P-glycoprotein inhibition: cell accumulation and equilibrium dialysis studies

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FNNM.12.104

NanoART, neuroAIDS and CNS drug delivery

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FNNM.12.104

Poly(ethylene oxide)-poly(propylene oxide) block copolymer micelles as drug delivery agents: improved hydrosolubility, stability and bioavailability of drugs

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FNNM.12.104

Semi-synthetic collagen/poloxamine matrices for tissue engineering

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FNNM.12.104

Collagen/poloxamine hydrogels: cytocompatibility of embedded HepG2 cells and surface-attached endothelial cells

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FNNM.12.104

Repair of bone defect using bone marrow cells and demineralized bone matrix supplemented with polymeric materials

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FNNM.12.104

Pharmacokinetics of nelfinavir and efavirenz in antiretroviral-naive, human immunodeficiency virus-infected subjects when administered alone or in combination with nucleoside analog reverse transcriptase inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FNNM.12.104

Poly (propyleneimine) dendrimer based nanocontainers for targeting of efavirenz to human monocytes/macrophages in vitro.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FNNM.12.104

Antiretroviral release from poly(DL-lactide-co-glycolide) nanoparticles in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FNNM.12.104

Analyses of nanoformulated antiretroviral drug charge, size, shape and content for uptake, drug release and antiviral activities in human monocyte-derived macrophages.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FNNM.12.104

Efavirenz-loaded polymeric micelles for pediatric anti-HIV pharmacotherapy with significantly higher oral bioavailability [corrected].

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FNNM.12.104

Oral pharmacokinetics of the anti-HIV efavirenz encapsulated within polymeric micelles

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FNNM.12.104

N-alkylation of poloxamines modulates micellar assembly and encapsulation and release of the antiretroviral efavirenz

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FNNM.12.104

A highly concentrated and taste-improved aqueous formulation of efavirenz for a more appropriate pediatric management of the anti-HIV therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FNNM.12.104

Nanoparticles for direct nose-to-brain delivery of drugs.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FNNM.12.104

Intranasal delivery to the central nervous system: mechanisms and experimental considerations

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FNNM.12.104

Cell-penetrating peptide-modified block copolymer micelles promote direct brain delivery via intranasal administration.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FNNM.12.104

Brain transport of neurotoxin-I with PLA nanoparticles through intranasal administration in rats: a microdialysis study.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FNNM.12.104

Intranasal delivery of zidovudine by PLA and PLA-PEG blend nanoparticles

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FNNM.12.104

Intranasal drug delivery of didanosine-loaded chitosan nanoparticles for brain targeting; an attractive route against infections caused by AIDS viruses

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FNNM.12.104

Formulation and evaluation of novel micellar nanocarrier for nasal delivery of sumatriptan

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FNNM.12.104

Is nose-to-brain transport of drugs in man a reality?

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FNNM.12.104

Single and mixed poloxamine micelles as nanocarriers for solubilization and sustained release of ethoxzolamide for topical glaucoma therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FNNM.12.104

Microdialysis in drug discovery

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FNNM.12.104

Nimodipine restores the altered hippocampal phenytoin pharmacokinetics in a refractory epileptic model.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FNNM.12.104

Kinetics and mechanism of hydrolysis of efavirenz

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FNNM.12.104

TAT-conjugated nanoparticles for the CNS delivery of anti-HIV drugs

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FNNM.12.104

Albumin turnover: experimental approach and its application in health and renal diseases

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FNNM.12.104

Influence of serum protein on polycarbonate-based copolymer micelles as a delivery system for a hydrophobic anti-cancer agent.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FNNM.12.104

Mixed micelles formed from graft and diblock copolymers for application in intracellular drug delivery

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FNNM.12.104

Distribution of intranasal instillations in mice: effects of volume, time, body position, and anesthesia

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FNNM.12.104

In vivo methods to study uptake of nanoparticles into the brain.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FNNM.12.104

Polymeric micelles for oral drug delivery

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FNNM.12.104

Transport of drugs across the blood-brain barrier by nanoparticles.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FNNM.12.104

Chemotherapy of brain tumour using doxorubicin bound to surfactant-coated poly(butyl cyanoacrylate) nanoparticles: revisiting the role of surfactants.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FNNM.12.104

Inhibition of P-glycoprotein pumps by PEO-PPO amphiphiles: branched versus linear derivatives

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FNNM.12.104

Poloxamines display a multiple inhibitory activity of ATP-binding cassette (ABC) transporters in cancer cell lines

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FNNM.12.104

Downregulation of mdr1 and abcg2 genes is a mechanism of inhibition of efflux pumps mediated by polymeric amphiphiles

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FNNM.12.104

Looking at the blood-brain barrier: molecular anatomy and possible investigation approaches

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FNNM.12.104

The brain targeting efficiency following nasally applied MPEG-PLA nanoparticles in rats.

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FNNM.12.104

Impact of current antiretroviral therapies on neuroAIDS

21 January 2018

1 reference

https://api.crossref.org/works/10.2217%2FNNM.12.104

21 January 2018

Identifiers

DOI

10.2217/NNM.12.104

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10 February 2018

PubMed ID

23173734

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10 February 2018